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Article: Therapy-related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukaemia

TitleTherapy-related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukaemia
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2001, v. 112 n. 2, p. 424-426 How to Cite?
AbstractTherapy-related myelodysplastic syndrome (t-MDS) is a very rare complication of allogeneic bone marrow transplantation (BMT). A woman with T acute lymphoblastic leukaemia (T-ALL) received an allogeneic BMT from a donor with the β-thalassaemic trait. Five years after BMT, the red cell indices returned to normal after an initial conversion to microcytosis, implying autologous haematopoietic regeneration. Seven years after BMT, thrombocytopenia developed and marrow examination confirmed t-MDS, with a characteristic karyotype 46.XX,inv(3)(q21:q26), del(5)(q13),add(17)(p11). Retrospective molecular analysis of donor/recipient chimaerism showed gradual regeneration of recipient cells after BMT, culminating at the time of t-MDS. Our findings illustrate the unusual occurrence of t-MDS after allogeneic BMT. Re-emergence of recipient haematopoesis may herald the development of a haematological malignancy different from the original neoplastic clone for which the BMT was performed.
Persistent Identifierhttp://hdl.handle.net/10722/162508
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorMa, SKen_US
dc.contributor.authorLeung, YHen_US
dc.contributor.authorSiu, LLPen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:20:37Z-
dc.date.available2012-09-05T05:20:37Z-
dc.date.issued2001en_US
dc.identifier.citationBritish Journal Of Haematology, 2001, v. 112 n. 2, p. 424-426en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162508-
dc.description.abstractTherapy-related myelodysplastic syndrome (t-MDS) is a very rare complication of allogeneic bone marrow transplantation (BMT). A woman with T acute lymphoblastic leukaemia (T-ALL) received an allogeneic BMT from a donor with the β-thalassaemic trait. Five years after BMT, the red cell indices returned to normal after an initial conversion to microcytosis, implying autologous haematopoietic regeneration. Seven years after BMT, thrombocytopenia developed and marrow examination confirmed t-MDS, with a characteristic karyotype 46.XX,inv(3)(q21:q26), del(5)(q13),add(17)(p11). Retrospective molecular analysis of donor/recipient chimaerism showed gradual regeneration of recipient cells after BMT, culminating at the time of t-MDS. Our findings illustrate the unusual occurrence of t-MDS after allogeneic BMT. Re-emergence of recipient haematopoesis may herald the development of a haematological malignancy different from the original neoplastic clone for which the BMT was performed.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia-Lymphoma, Adult T-Cell - Complications - Genetics - Therapyen_US
dc.subject.meshMyelodysplastic Syndromes - Complications - Etiology - Geneticsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTransplantation, Homologousen_US
dc.titleTherapy-related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailLeung, YH:ayhleung@hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityLeung, YH=rp00265en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2001.02518.xen_US
dc.identifier.pmid11167842-
dc.identifier.scopuseid_2-s2.0-0035127293en_US
dc.identifier.hkuros59924-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035127293&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume112en_US
dc.identifier.issue2en_US
dc.identifier.spage424en_US
dc.identifier.epage426en_US
dc.identifier.isiWOS:000166974500028-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridLie, AKW=24284842400en_US
dc.identifier.scopusauthoridMa, SK=37020910400en_US
dc.identifier.scopusauthoridLeung, YH=7403012668en_US
dc.identifier.scopusauthoridSiu, LLP=35574705900en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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