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Article: Evaluation of five commercial serological tests for the detection of Helicobacter pylori infection in Chinese

TitleEvaluation of five commercial serological tests for the detection of Helicobacter pylori infection in Chinese
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2001, v. 15 n. 5, p. 703-706 How to Cite?
AbstractBackground: Commercial serological tests for the detection of Helicobacter pylori infection must be locally validated. We evaluated the accuracy of five commercial tests in the Chinese population. Methods: Serum samples were collected from patients referred for upper endoscopy. Antral biopsies were taken for histological examination and culture of H. pylori. The gold standard for diagnosing H. pylori infection was positive histological staining and/or positive H. pylori culture. The serum samples were tested for H. pylori antibodies using the following tests: (i) Cobas Core Anti-H. pylori EIA: (ii) GAP IgG; (iii) GAP IgM; (iv) H. pylori microwell EIA (Quidel): and (v) Premier H. pylori. The sensitivity, specificity and accuracy of each test was calculated according to the manufacturers' instructions or according to a new cut-off value. Results: A total of 158 patients were recruited amongst whom 114 (72%) were H. pylori-positive. Indeterminate results varied from 7% to 19%. The accuracy of the tests varied from 57% to 85%. By using new cut-off values, the accuracy was much improved, ranging from 73.4:% to 86.7%. Conclusions: By defining new cut-off values for the Chinese population, we were able to improve the performance of some of the serology tests. This illustrates the importance of local validation.
Persistent Identifierhttp://hdl.handle.net/10722/162495
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSzeto, MLen_US
dc.contributor.authorLee, CKen_US
dc.contributor.authorYee, YKen_US
dc.contributor.authorLi, KFen_US
dc.contributor.authorLee, WKen_US
dc.contributor.authorLee, CCen_US
dc.contributor.authorQue, TLen_US
dc.contributor.authorWong, BCYen_US
dc.date.accessioned2012-09-05T05:20:31Z-
dc.date.available2012-09-05T05:20:31Z-
dc.date.issued2001en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2001, v. 15 n. 5, p. 703-706en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/162495-
dc.description.abstractBackground: Commercial serological tests for the detection of Helicobacter pylori infection must be locally validated. We evaluated the accuracy of five commercial tests in the Chinese population. Methods: Serum samples were collected from patients referred for upper endoscopy. Antral biopsies were taken for histological examination and culture of H. pylori. The gold standard for diagnosing H. pylori infection was positive histological staining and/or positive H. pylori culture. The serum samples were tested for H. pylori antibodies using the following tests: (i) Cobas Core Anti-H. pylori EIA: (ii) GAP IgG; (iii) GAP IgM; (iv) H. pylori microwell EIA (Quidel): and (v) Premier H. pylori. The sensitivity, specificity and accuracy of each test was calculated according to the manufacturers' instructions or according to a new cut-off value. Results: A total of 158 patients were recruited amongst whom 114 (72%) were H. pylori-positive. Indeterminate results varied from 7% to 19%. The accuracy of the tests varied from 57% to 85%. By using new cut-off values, the accuracy was much improved, ranging from 73.4:% to 86.7%. Conclusions: By defining new cut-off values for the Chinese population, we were able to improve the performance of some of the serology tests. This illustrates the importance of local validation.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Diagnosis - Immunologyen_US
dc.subject.meshHelicobacter Pylori - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSerologic Testsen_US
dc.titleEvaluation of five commercial serological tests for the detection of Helicobacter pylori infection in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2036.2001.00961.xen_US
dc.identifier.pmid11328265-
dc.identifier.scopuseid_2-s2.0-0035031627en_US
dc.identifier.hkuros61686-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035031627&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.identifier.spage703en_US
dc.identifier.epage706en_US
dc.identifier.isiWOS:000168380300016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSzeto, ML=6602526385en_US
dc.identifier.scopusauthoridLee, CK=7410153594en_US
dc.identifier.scopusauthoridYee, YK=7004400469en_US
dc.identifier.scopusauthoridLi, KF=9036854600en_US
dc.identifier.scopusauthoridLee, WK=21743375200en_US
dc.identifier.scopusauthoridLee, CC=18836231100en_US
dc.identifier.scopusauthoridQue, TL=7003786628en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US

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