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Article: Helper T-lymphocyte precursor frequency predicts the occurrence of graft-versus-host disease and disease relapse after allogeneic bone marrow transplantation from HLA-identical siblings

TitleHelper T-lymphocyte precursor frequency predicts the occurrence of graft-versus-host disease and disease relapse after allogeneic bone marrow transplantation from HLA-identical siblings
Authors
Issue Date2001
Citation
Haematologica, 2001, v. 86 n. 6, p. 652-656 How to Cite?
AbstractBackground and Objectives. Donor helper T-lymphocytes may be involved in graft-versus-host disease (GVHD) and a graft-versus-leukemia effect after bone marrow transplantation (BMT). We assayed donor helper T-lymphocyte precursor frequencies (HTLPf) to see whether they could predict the severity of GVHD and disease relapse after transplantation, thereby facilitating donor selection, pre-transplant counselling and modification of GVHD prophylaxis after BMT. Design and Methods. Thirty-six consecutive adult BMT recipients and their HLA-identical sibling donors were recruited. HTLPf was measured as a function of interleukin-2 secretion by alloreactive donor T-cells using a limiting dilution assay. Patients were followed prospectively to assess the severity of GVHD and the status of the pdmary disease after BMT. Results. Eight donors had HTLPf less than or equal to 10-6; no recipients of these grafts developed severe GVHD after transplantation. Twenty-eight donors had HTLPf greater than 10-5 and 18 recipients of these grafts developed severe GVHD (≥ grade 2) (X2 test, p<0.01). Seven donors had HTLPf greater than 10-5 and no recipient had disease relapse. Twenty-nine donors had HTLPf less than or equal to 10-5, 11 recipients of these grafts developed disease relapse (X2 test, p=0.08). Interpretation and Conclusions. BMT recipients from HLA-identical sibling donors with low (<10-6) and high (> 10-5) HTLPf may have a low risk of acute GVHD and disease relapse after transplantation. © 2001, Ferrata Storti Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/162484
ISSN
2015 Impact Factor: 6.671
2015 SCImago Journal Rankings: 3.010
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYHen_US
dc.contributor.authorKwok, Jen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorChen, Pen_US
dc.contributor.authorChen, FEen_US
dc.contributor.authorLiang, Ren_US
dc.date.accessioned2012-09-05T05:20:26Z-
dc.date.available2012-09-05T05:20:26Z-
dc.date.issued2001en_US
dc.identifier.citationHaematologica, 2001, v. 86 n. 6, p. 652-656en_US
dc.identifier.issn0390-6078en_US
dc.identifier.urihttp://hdl.handle.net/10722/162484-
dc.description.abstractBackground and Objectives. Donor helper T-lymphocytes may be involved in graft-versus-host disease (GVHD) and a graft-versus-leukemia effect after bone marrow transplantation (BMT). We assayed donor helper T-lymphocyte precursor frequencies (HTLPf) to see whether they could predict the severity of GVHD and disease relapse after transplantation, thereby facilitating donor selection, pre-transplant counselling and modification of GVHD prophylaxis after BMT. Design and Methods. Thirty-six consecutive adult BMT recipients and their HLA-identical sibling donors were recruited. HTLPf was measured as a function of interleukin-2 secretion by alloreactive donor T-cells using a limiting dilution assay. Patients were followed prospectively to assess the severity of GVHD and the status of the pdmary disease after BMT. Results. Eight donors had HTLPf less than or equal to 10-6; no recipients of these grafts developed severe GVHD after transplantation. Twenty-eight donors had HTLPf greater than 10-5 and 18 recipients of these grafts developed severe GVHD (≥ grade 2) (X2 test, p<0.01). Seven donors had HTLPf greater than 10-5 and no recipient had disease relapse. Twenty-nine donors had HTLPf less than or equal to 10-5, 11 recipients of these grafts developed disease relapse (X2 test, p=0.08). Interpretation and Conclusions. BMT recipients from HLA-identical sibling donors with low (<10-6) and high (> 10-5) HTLPf may have a low risk of acute GVHD and disease relapse after transplantation. © 2001, Ferrata Storti Foundation.en_US
dc.languageengen_US
dc.relation.ispartofHaematologicaen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft Vs Host Disease - Blood - Diagnosis - Etiologyen_US
dc.subject.meshHematopoietic Stem Cells - Cytologyen_US
dc.subject.meshHistocompatibility Testingen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocyte Counten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshT-Lymphocytes, Helper-Inducer - Cytologyen_US
dc.subject.meshTransplantation, Homologous - Adverse Effectsen_US
dc.subject.meshTransplantation, Isogeneic - Adverse Effectsen_US
dc.titleHelper T-lymphocyte precursor frequency predicts the occurrence of graft-versus-host disease and disease relapse after allogeneic bone marrow transplantation from HLA-identical siblingsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityLeung, AYH=rp00265en_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid11418376-
dc.identifier.scopuseid_2-s2.0-0034955843en_US
dc.identifier.hkuros59653-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034955843&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume86en_US
dc.identifier.issue6en_US
dc.identifier.spage652en_US
dc.identifier.epage656en_US
dc.identifier.isiWOS:000169524900015-
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridLeung, AYH=7403012668en_US
dc.identifier.scopusauthoridKwok, J=7006208874en_US
dc.identifier.scopusauthoridLie, AKW=24284842400en_US
dc.identifier.scopusauthoridChen, P=7408355272en_US
dc.identifier.scopusauthoridChen, FE=25928259900en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US

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