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Article: Effect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia

TitleEffect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasia
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2001, v. 15 n. 9, p. 1505-1511 How to Cite?
AbstractBackground and aims: Cyclins and cyclin-dependent kinase inhibitors play a crucial role in the control of cell cycle transitions, Enhanced expression of cyclin D2 and reduced expression of p27kip1 (p27) have been implicated in the pathogenesis of cancer. Because intestinal metaplasia has been regarded as a premalignant lesion, we investigated the expression of cyclin D2 and p27 in Helicobacter pylori-associated chronic gastritis with and without intestinal metaplasia, and followed the changes after H. pylori eradication. Methods: Expression of cyclin D2 and p27 was studied by immunohistochemistry in 59 patients (including 35 patients with intestinal metaplasia) and in 10 gastric cancer patients. Among them, 29 H. pylori-infected patients had serial gastric biopsies taken before and at 1-year after eradication of H. pylori. Results: Expression of cyclin D2 was significantly higher in gastric cancers when compared to their adjacent non-tumour tissues (median score 3 vs. 1, P = 0.015). Over-expression of cyclin D2 was detected in H. pylori-associated chronic gastritis and intestinal metaplasia, which was reduced after eradication of the organism (median score 2 vs. 1, P = 0.037 in chronic gastritis: median score 2 vs. O, P = 0.008 in intestinal metaplasia). While the normal gastric mucosa showed strong p27 expression, five of the 10 gastric cancer tissues exhibited reduced p27 expression (P = 0.039). Diminished p27 expression was also seen in intestinal metaplasia, which was restored 1-year after H. pylori eradication (eight out of 16 vs. one out of 16, P = 0.018). Reduced expression of p27 was frequently associated with increased cyclin D2 expression in H. pylori-associated intestinal metaplasia (P = 0.02). Conclusion: Over-expression of cyclin D2 and reduced expression of p27 are closely linked to H. pylori-associated intestinal metaplasia. Eradication of H. pylori infection reverses the aberrant expression of cyclin D2 and p27 in intestinal metaplasia.
Persistent Identifierhttp://hdl.handle.net/10722/162471
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Jen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorTo, KFen_US
dc.contributor.authorEbert, MPAen_US
dc.contributor.authorGo, MYYen_US
dc.contributor.authorChan, WYen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorChung, SCSen_US
dc.contributor.authorMalfertheiner, Pen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:20:17Z-
dc.date.available2012-09-05T05:20:17Z-
dc.date.issued2001en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2001, v. 15 n. 9, p. 1505-1511en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/162471-
dc.description.abstractBackground and aims: Cyclins and cyclin-dependent kinase inhibitors play a crucial role in the control of cell cycle transitions, Enhanced expression of cyclin D2 and reduced expression of p27kip1 (p27) have been implicated in the pathogenesis of cancer. Because intestinal metaplasia has been regarded as a premalignant lesion, we investigated the expression of cyclin D2 and p27 in Helicobacter pylori-associated chronic gastritis with and without intestinal metaplasia, and followed the changes after H. pylori eradication. Methods: Expression of cyclin D2 and p27 was studied by immunohistochemistry in 59 patients (including 35 patients with intestinal metaplasia) and in 10 gastric cancer patients. Among them, 29 H. pylori-infected patients had serial gastric biopsies taken before and at 1-year after eradication of H. pylori. Results: Expression of cyclin D2 was significantly higher in gastric cancers when compared to their adjacent non-tumour tissues (median score 3 vs. 1, P = 0.015). Over-expression of cyclin D2 was detected in H. pylori-associated chronic gastritis and intestinal metaplasia, which was reduced after eradication of the organism (median score 2 vs. 1, P = 0.037 in chronic gastritis: median score 2 vs. O, P = 0.008 in intestinal metaplasia). While the normal gastric mucosa showed strong p27 expression, five of the 10 gastric cancer tissues exhibited reduced p27 expression (P = 0.039). Diminished p27 expression was also seen in intestinal metaplasia, which was restored 1-year after H. pylori eradication (eight out of 16 vs. one out of 16, P = 0.018). Reduced expression of p27 was frequently associated with increased cyclin D2 expression in H. pylori-associated intestinal metaplasia (P = 0.02). Conclusion: Over-expression of cyclin D2 and reduced expression of p27 are closely linked to H. pylori-associated intestinal metaplasia. Eradication of H. pylori infection reverses the aberrant expression of cyclin D2 and p27 in intestinal metaplasia.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.subject.meshCyclin D2en_US
dc.subject.meshCyclin-Dependent Kinases - Metabolismen_US
dc.subject.meshCyclins - Metabolismen_US
dc.subject.meshHelicobacter Infections - Drug Therapy - Metabolismen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshIntestinal Neoplasms - Pathologyen_US
dc.subject.meshMetaplasiaen_US
dc.subject.meshStomach Neoplasms - Metabolism - Microbiology - Pathologyen_US
dc.titleEffect of Helicobacter pylori eradication on expression of cyclin D2 and p27 in gastric intestinal metaplasiaen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2036.2001.01038.xen_US
dc.identifier.pmid11552926-
dc.identifier.scopuseid_2-s2.0-0034853178en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034853178&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue9en_US
dc.identifier.spage1505en_US
dc.identifier.epage1511en_US
dc.identifier.isiWOS:000171126900033-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYu, J=35351306800en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US
dc.identifier.scopusauthoridEbert, MPA=35239660600en_US
dc.identifier.scopusauthoridGo, MYY=7101882939en_US
dc.identifier.scopusauthoridChan, WY=37041920900en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridChung, SCS=19642462800en_US
dc.identifier.scopusauthoridMalfertheiner, P=36048150200en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US

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