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Article: Chronic T-cell lymphoproliferative disease expressing natural killer cell receptors: Clinicopathological and molecular features

TitleChronic T-cell lymphoproliferative disease expressing natural killer cell receptors: Clinicopathological and molecular features
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2001, v. 129 n. 2, p. 168-172 How to Cite?
AbstractThe frequency and clinicopathological significance of the expression of natural killer cell receptors (NKRs) in T-cell malignancies remain undefined. A 71-year-old man presented with leukocytosis, generalized lymphoadenopathy, and hepatosplenomegaly. Bone marrow and lymph node biopsies showed a T-cell lymphoproliferative disease expressing NKRs (CD2 +, CD3 +, CD4 +, CD5 +, CD7 +, CD8 -, CD56 -, CD94 +, CD158a +, CD158b +, CD161 -, p70 -, TCRαβ +, TCRγδ -, TIA-1 -). An abnormal clone, 46,Y,add(X)(p14),der(1)t(1;6)(p33;p21),t(7;12)(p10;q10), was found on conventional karyotyping. Comparative genomic hybridization confirmed these findings, and showed a deletion of 12p that was not apparent on karyotyping. Clinically, the disease remained indolent and responded transiently to purine analogs but not to intensive chemotherapy. Peripheral T-cell lymphoproliferative disease of CD4 +αβ +NKR + phenotype is hitherto undescribed. The issues of whether this case was derived from transformation of a rare T-cell subtype or represented aberrant T-cell expression of NK-cell antigens, and the clinicopathologic significance of these T-cell neoplasms warrant further studies. © 2001 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162469
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.contributor.authorLam, CCKen_US
dc.contributor.authorChoy, Cen_US
dc.contributor.authorMan, Cen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorSiu, LLPen_US
dc.date.accessioned2012-09-05T05:20:15Z-
dc.date.available2012-09-05T05:20:15Z-
dc.date.issued2001en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2001, v. 129 n. 2, p. 168-172en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162469-
dc.description.abstractThe frequency and clinicopathological significance of the expression of natural killer cell receptors (NKRs) in T-cell malignancies remain undefined. A 71-year-old man presented with leukocytosis, generalized lymphoadenopathy, and hepatosplenomegaly. Bone marrow and lymph node biopsies showed a T-cell lymphoproliferative disease expressing NKRs (CD2 +, CD3 +, CD4 +, CD5 +, CD7 +, CD8 -, CD56 -, CD94 +, CD158a +, CD158b +, CD161 -, p70 -, TCRαβ +, TCRγδ -, TIA-1 -). An abnormal clone, 46,Y,add(X)(p14),der(1)t(1;6)(p33;p21),t(7;12)(p10;q10), was found on conventional karyotyping. Comparative genomic hybridization confirmed these findings, and showed a deletion of 12p that was not apparent on karyotyping. Clinically, the disease remained indolent and responded transiently to purine analogs but not to intensive chemotherapy. Peripheral T-cell lymphoproliferative disease of CD4 +αβ +NKR + phenotype is hitherto undescribed. The issues of whether this case was derived from transformation of a rare T-cell subtype or represented aberrant T-cell expression of NK-cell antigens, and the clinicopathologic significance of these T-cell neoplasms warrant further studies. © 2001 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAnemia - Etiologyen_US
dc.subject.meshAntigens, Cd - Analysis - Biosynthesisen_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshBone Marrow Cells - Metabolism - Pathologyen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshKiller Cells, Natural - Metabolismen_US
dc.subject.meshLymphatic Diseases - Etiologyen_US
dc.subject.meshLymphoproliferative Disorders - Diagnosis - Genetics - Metabolism - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPleural Effusion, Malignant - Etiologyen_US
dc.subject.meshReceptors, Antigen, T-Cell - Analysis - Biosynthesis - Classificationen_US
dc.subject.meshT-Lymphocytes - Metabolism - Pathologyen_US
dc.subject.meshTranslocation, Genetic - Geneticsen_US
dc.titleChronic T-cell lymphoproliferative disease expressing natural killer cell receptors: Clinicopathological and molecular featuresen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(01)00451-4en_US
dc.identifier.pmid11566350-
dc.identifier.scopuseid_2-s2.0-0034837042en_US
dc.identifier.hkuros108106-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034837042&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume129en_US
dc.identifier.issue2en_US
dc.identifier.spage168en_US
dc.identifier.epage172en_US
dc.identifier.isiWOS:000171105500014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridLam, CCK=16947291300en_US
dc.identifier.scopusauthoridChoy, C=7202840937en_US
dc.identifier.scopusauthoridMan, C=7005722377en_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridSiu, LLP=35574705900en_US

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