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Article: Plasma nitric oxide is associated with the occurrence of moderate to severe acute graft-versus-host disease in hemopoietic stem cell transplant recipients

TitlePlasma nitric oxide is associated with the occurrence of moderate to severe acute graft-versus-host disease in hemopoietic stem cell transplant recipients
Authors
Issue Date2001
PublisherFondazione Ferrata Storti. The Journal's web site is located at http://www.haematologica.org
Citation
Haematologica, 2001, v. 86 n. 9, p. 972-976 How to Cite?
AbstractBackground and Objectives. Nitric oxide (NO) has been implicated as one of the mediators of acute graft-versus-host disease (GVHD) but reports on its measurement during hemopoietic stem cell transplantation (HSCT) in humans are scarce. The present study was conducted to measure the plasma NO in HSCT recipients in order to delineate its relationships with acute GVHD. Design and Methods. Thirty-nine randomly selected patients undergoing HSCT were recruited. Thirty-one patients received an allogeneic transplant (ALLO) from HLA-identical siblings (n=20), a haploidentical parent (n=1) or matched unrelated donors (n=10). Eight patients received an autologous (AUTO) HSCT. Plasma levels of nitrite/nitrate (NO2-/NO3-), the end-product of NO, were measured by chemiluminescence and the results were correlated with the occurrence and severity of acute GVHD. Results. Baseline NO2-/NO3- levels before HSCT were similar in the ALLO and AUTO patients (17.4 vs 21.1 μmol/L, p>0.05). Significant increases in plasma NO2-/NO3- (> 2 times the baseline level) were found in all 13 patients with acute GVHD ≥ grade 2, in 15 out of 18 patients with acute GVHD grade ≤ 1 and 3 out of 8 patients receiving autologous HSCT. The increase in NO2-/NO3- among the three groups of patients was significantly different (135.5 vs 56.3 vs 36.6 μmol/L, p < 0.001). The average NO production, calculated as the area under the curve, was also significantly differently among the three groups of patients (44.5 vs 30.0 vs 23.8 μmol/L, p < 0.001). Interpretation and Conclusions. Plasma NO in HSCT recipients is quantitatively associated with the occurrence of acute GVHD; its role remains to be determined. ©2001, Ferrata Storti Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/162467
ISSN
2015 Impact Factor: 6.671
2015 SCImago Journal Rankings: 3.010
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChoi, ICYen_US
dc.contributor.authorFung, PCWen_US
dc.contributor.authorLeung, AYHen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorLiang, Ren_US
dc.date.accessioned2012-09-05T05:20:13Z-
dc.date.available2012-09-05T05:20:13Z-
dc.date.issued2001en_US
dc.identifier.citationHaematologica, 2001, v. 86 n. 9, p. 972-976en_US
dc.identifier.issn0390-6078en_US
dc.identifier.urihttp://hdl.handle.net/10722/162467-
dc.description.abstractBackground and Objectives. Nitric oxide (NO) has been implicated as one of the mediators of acute graft-versus-host disease (GVHD) but reports on its measurement during hemopoietic stem cell transplantation (HSCT) in humans are scarce. The present study was conducted to measure the plasma NO in HSCT recipients in order to delineate its relationships with acute GVHD. Design and Methods. Thirty-nine randomly selected patients undergoing HSCT were recruited. Thirty-one patients received an allogeneic transplant (ALLO) from HLA-identical siblings (n=20), a haploidentical parent (n=1) or matched unrelated donors (n=10). Eight patients received an autologous (AUTO) HSCT. Plasma levels of nitrite/nitrate (NO2-/NO3-), the end-product of NO, were measured by chemiluminescence and the results were correlated with the occurrence and severity of acute GVHD. Results. Baseline NO2-/NO3- levels before HSCT were similar in the ALLO and AUTO patients (17.4 vs 21.1 μmol/L, p>0.05). Significant increases in plasma NO2-/NO3- (> 2 times the baseline level) were found in all 13 patients with acute GVHD ≥ grade 2, in 15 out of 18 patients with acute GVHD grade ≤ 1 and 3 out of 8 patients receiving autologous HSCT. The increase in NO2-/NO3- among the three groups of patients was significantly different (135.5 vs 56.3 vs 36.6 μmol/L, p < 0.001). The average NO production, calculated as the area under the curve, was also significantly differently among the three groups of patients (44.5 vs 30.0 vs 23.8 μmol/L, p < 0.001). Interpretation and Conclusions. Plasma NO in HSCT recipients is quantitatively associated with the occurrence of acute GVHD; its role remains to be determined. ©2001, Ferrata Storti Foundation.en_US
dc.languageengen_US
dc.publisherFondazione Ferrata Storti. The Journal's web site is located at http://www.haematologica.org-
dc.relation.ispartofHaematologicaen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft Vs Host Disease - Blood - Etiologyen_US
dc.subject.meshHematopoietic Stem Cell Transplantation - Adverse Effectsen_US
dc.subject.meshHistocompatibilityen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNitric Oxide - Blooden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTransplantation, Autologousen_US
dc.subject.meshTransplantation, Homologousen_US
dc.titlePlasma nitric oxide is associated with the occurrence of moderate to severe acute graft-versus-host disease in hemopoietic stem cell transplant recipientsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityLeung, AYH=rp00265en_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid11532626-
dc.identifier.scopuseid_2-s2.0-0034792103en_US
dc.identifier.hkuros66646-
dc.identifier.hkuros73956-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034792103&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume86en_US
dc.identifier.issue9en_US
dc.identifier.spage972en_US
dc.identifier.epage976en_US
dc.identifier.isiWOS:000171252300011-
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridChoi, ICY=7401471716en_US
dc.identifier.scopusauthoridFung, PCW=7101613315en_US
dc.identifier.scopusauthoridLeung, AYH=7403012668en_US
dc.identifier.scopusauthoridLie, AKW=24284842400en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US

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