File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Role of capsaicin sensory nerves and EGF in the healing of gastric ulcer in rats

TitleRole of capsaicin sensory nerves and EGF in the healing of gastric ulcer in rats
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2000, v. 66 n. 15, p. PL213-PL220 How to Cite?
AbstractAccumulating evidence indicates that capsaicin sensitive afferent fibers play a pivotal role not only in gastroprotection but also in ulcer healing. Denervation of capsaicin sensitive afferent fibers exerts an adverse action on these effects. However, whether such an action is mediated through a depression on epidermal growth factor (EGF) is underfined. In this study, the effects of denervation of sensory neurons with capsaicin (100 mg/kg, s.c.) on acetic acid-induced chronic gastric ulcers and their relationship with the EGF expression in salivary glands, serum and gastric mucosa were investigated. Capsaicin significantly increased ulcer size, decreased gastric mucosal cell proliferation at the ulcer margin, angiogenesis in the granulation tissue and also gastric mucus content. Ulcer induction by itself dramatically elevated EGF levels in salivary glands and serum on day 1 and 4, and also in the gastric mucosa on day 4. However, capsaicin completely abolished these effects. It is concluded that stimulation of EGF expression in salivary glands and serum may be one of the mechanisms by which capsaicin sensitive nerves contribute to the gastroprotective and ulcer healing actions in the stomach. (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/162449
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_US
dc.contributor.authorChow, JYCen_US
dc.contributor.authorWong, BCYen_US
dc.contributor.authorCho, CHen_US
dc.date.accessioned2012-09-05T05:20:03Z-
dc.date.available2012-09-05T05:20:03Z-
dc.date.issued2000en_US
dc.identifier.citationLife Sciences, 2000, v. 66 n. 15, p. PL213-PL220en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/162449-
dc.description.abstractAccumulating evidence indicates that capsaicin sensitive afferent fibers play a pivotal role not only in gastroprotection but also in ulcer healing. Denervation of capsaicin sensitive afferent fibers exerts an adverse action on these effects. However, whether such an action is mediated through a depression on epidermal growth factor (EGF) is underfined. In this study, the effects of denervation of sensory neurons with capsaicin (100 mg/kg, s.c.) on acetic acid-induced chronic gastric ulcers and their relationship with the EGF expression in salivary glands, serum and gastric mucosa were investigated. Capsaicin significantly increased ulcer size, decreased gastric mucosal cell proliferation at the ulcer margin, angiogenesis in the granulation tissue and also gastric mucus content. Ulcer induction by itself dramatically elevated EGF levels in salivary glands and serum on day 1 and 4, and also in the gastric mucosa on day 4. However, capsaicin completely abolished these effects. It is concluded that stimulation of EGF expression in salivary glands and serum may be one of the mechanisms by which capsaicin sensitive nerves contribute to the gastroprotective and ulcer healing actions in the stomach. (C) 2000 Elsevier Science Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCapsaicin - Pharmacologyen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshEpidermal Growth Factor - Blood - Metabolism - Pharmacologyen_US
dc.subject.meshGastric Mucosa - Drug Effects - Metabolismen_US
dc.subject.meshGranulation Tissue - Cytology - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMucus - Metabolism - Secretionen_US
dc.subject.meshNeovascularization, Physiologic - Drug Effectsen_US
dc.subject.meshNeurons, Afferent - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSalivary Glands - Drug Effects - Metabolismen_US
dc.subject.meshStomach Ulcer - Pathologyen_US
dc.titleRole of capsaicin sensory nerves and EGF in the healing of gastric ulcer in ratsen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0024-3205(00)00459-8en_US
dc.identifier.pmid11210723-
dc.identifier.scopuseid_2-s2.0-0034599154en_US
dc.identifier.hkuros50202-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034599154&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume66en_US
dc.identifier.issue15en_US
dc.identifier.spagePL213en_US
dc.identifier.epagePL220en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMa, L=36072648200en_US
dc.identifier.scopusauthoridChow, JYC=7401728865en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridCho, CH=14067000400en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats