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Article: Novel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantation

TitleNovel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantation
Authors
Chan, VYam, IYip, BAu, PShing, MKLi, CKChan, TK
KeywordsBCR-ABL
Chronic myelogenous leukaemia
Philadelphia chromosome
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2000, v. 111 n. 2, p. 644-646 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.2000.02394.x
AbstractWe identified a novel BCR-ABL transcript in a chronic myelogenous leukaemia (CML) patient who relapsed after bone marrow transplantation (BMT), containing a fusion between part of BCR exon 3, 44 nucleotides derived from ABL intron 1b and ABL exon 2. The breakpoints were located within BCR exon 3 on chromosome 22 and within the ABL intron 1b on chromosome 9, and the transcript derives from a splicing of ABL exon 2 to a putative splicing acceptor site 44 nucleotides downstream to the breakpoint on chromosome 9. The patient's clinical course strengthens the idea that short forms of BCR-ABL transcripts are associated with a more aggressive disease.
Persistent Identifierhttp://hdl.handle.net/10722/162444
ISSN
0007-1048
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.574
ISI Accession Number ID
WOS:000165827300040
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorYam, Ien_US
dc.contributor.authorYip, Ben_US
dc.contributor.authorAu, Pen_US
dc.contributor.authorShing, MKen_US
dc.contributor.authorLi, CKen_US
dc.contributor.authorChan, TKen_US
dc.date.accessioned2012-09-05T05:19:58Z-
dc.date.available2012-09-05T05:19:58Z-
dc.date.issued2000en_US
dc.identifier.citationBritish Journal Of Haematology, 2000, v. 111 n. 2, p. 644-646en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162444-
dc.description.abstractWe identified a novel BCR-ABL transcript in a chronic myelogenous leukaemia (CML) patient who relapsed after bone marrow transplantation (BMT), containing a fusion between part of BCR exon 3, 44 nucleotides derived from ABL intron 1b and ABL exon 2. The breakpoints were located within BCR exon 3 on chromosome 22 and within the ABL intron 1b on chromosome 9, and the transcript derives from a splicing of ABL exon 2 to a putative splicing acceptor site 44 nucleotides downstream to the breakpoint on chromosome 9. The patient's clinical course strengthens the idea that short forms of BCR-ABL transcripts are associated with a more aggressive disease.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subjectBCR-ABL-
dc.subjectChronic myelogenous leukaemia-
dc.subjectPhiladelphia chromosome-
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantationen_US
dc.subject.meshFusion Proteins, Bcr-Abl - Geneticsen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, Bcr-Abl Positive - Genetics - Surgeryen_US
dc.subject.meshMaleen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.titleNovel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantationen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2000.02394.xen_US
dc.identifier.pmid11122114-
dc.identifier.scopuseid_2-s2.0-0034532961en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034532961&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume111en_US
dc.identifier.issue2en_US
dc.identifier.spage644en_US
dc.identifier.epage646en_US
dc.identifier.isiWOS:000165827300040-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridYam, I=6603358817en_US
dc.identifier.scopusauthoridYip, B=16685586100en_US
dc.identifier.scopusauthoridAu, P=18533445100en_US
dc.identifier.scopusauthoridShing, MK=7006423848en_US
dc.identifier.scopusauthoridLi, CK=15122650100en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.issnl0007-1048-

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