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Article: Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions

TitleCyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions
Authors
Issue Date2000
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 2000, v. 157 n. 3, p. 729-735 How to Cite?
AbstractExpression of cyclooxygenase-2 (COX-2) in various stages of the Helicobacter pylori-associated gastric carcinogenesis pathway has not been elucidated. We investigated the distribution and intensity of COX-2 expression in premalignant and malignant gastric lesions, and monitored the changes after H. pylori eradication. Gastric biopsies from H. pylori-infected patients with chronic active gastritis, gastric atrophy, intestinal metaplasia (IM), gastric adenocarcinoma, and noninfected controls were studied. Expression of COX-2 was evaluated by immunohistochemistry and in situ hybridization. Endoscopic biopsies were repeated 1 year after successful eradication of H. pylori in a group of IM patients for comparing COX-2 expression and progression of IM. In all H. pylori-infected patients, COX-2 expression was predominantly found in the foveolar and glandular epithelium and, to a lesser extent, in the lamina propria. In the non-infected group, only 35% of cases demonstrated weak COX-2 expression. Intensity of COX-2 was not significantly different between the chronic active gastritis, gastric atrophy, IM, and gastric adenocarcinoma groups. In 17 patients with IM, COX-2 expressions in the epithelial cells and stromal cells were reduced 1 year after H. pylori eradication. However, the changes in COX-2 expression did not correlate with progression/regression of IM. Both premalignant and malignant gastric lesions demonstrate strong COX-2 expression. Successful eradication of H. pylori leads to down-regulation of COX-2 expression but failed to reverse IM at 1 year.
Persistent Identifierhttp://hdl.handle.net/10722/162443
ISSN
2015 Impact Factor: 4.206
2015 SCImago Journal Rankings: 2.653
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSung, JJYen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorGo, MYYen_US
dc.contributor.authorTo, KFen_US
dc.contributor.authorCheng, ASLen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorChan, FKLen_US
dc.date.accessioned2012-09-05T05:19:58Z-
dc.date.available2012-09-05T05:19:58Z-
dc.date.issued2000en_US
dc.identifier.citationAmerican Journal Of Pathology, 2000, v. 157 n. 3, p. 729-735en_US
dc.identifier.issn0002-9440en_US
dc.identifier.urihttp://hdl.handle.net/10722/162443-
dc.description.abstractExpression of cyclooxygenase-2 (COX-2) in various stages of the Helicobacter pylori-associated gastric carcinogenesis pathway has not been elucidated. We investigated the distribution and intensity of COX-2 expression in premalignant and malignant gastric lesions, and monitored the changes after H. pylori eradication. Gastric biopsies from H. pylori-infected patients with chronic active gastritis, gastric atrophy, intestinal metaplasia (IM), gastric adenocarcinoma, and noninfected controls were studied. Expression of COX-2 was evaluated by immunohistochemistry and in situ hybridization. Endoscopic biopsies were repeated 1 year after successful eradication of H. pylori in a group of IM patients for comparing COX-2 expression and progression of IM. In all H. pylori-infected patients, COX-2 expression was predominantly found in the foveolar and glandular epithelium and, to a lesser extent, in the lamina propria. In the non-infected group, only 35% of cases demonstrated weak COX-2 expression. Intensity of COX-2 was not significantly different between the chronic active gastritis, gastric atrophy, IM, and gastric adenocarcinoma groups. In 17 patients with IM, COX-2 expressions in the epithelial cells and stromal cells were reduced 1 year after H. pylori eradication. However, the changes in COX-2 expression did not correlate with progression/regression of IM. Both premalignant and malignant gastric lesions demonstrate strong COX-2 expression. Successful eradication of H. pylori leads to down-regulation of COX-2 expression but failed to reverse IM at 1 year.en_US
dc.languageengen_US
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_US
dc.relation.ispartofAmerican Journal of Pathologyen_US
dc.subject.meshAdenocarcinoma - Enzymology - Microbiology - Pathologyen_US
dc.subject.meshCyclooxygenase 2en_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshGastric Mucosa - Enzymology - Microbiology - Pathologyen_US
dc.subject.meshHelicobacter Infections - Enzymology - Microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshIsoenzymes - Genetics - Metabolismen_US
dc.subject.meshMembrane Proteinsen_US
dc.subject.meshPrecancerous Conditions - Enzymology - Microbiology - Pathologyen_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Genetics - Metabolismen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshStomach Neoplasms - Enzymology - Microbiology - Pathologyen_US
dc.titleCyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesionsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0002-9440(10)64586-5-
dc.identifier.pmid10980112-
dc.identifier.scopuseid_2-s2.0-0034495173en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034495173&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume157en_US
dc.identifier.issue3en_US
dc.identifier.spage729en_US
dc.identifier.epage735en_US
dc.identifier.isiWOS:000089207200006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSung, JJY=24473715000en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridGo, MYY=7101882939en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US
dc.identifier.scopusauthoridCheng, ASL=7402075036en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US

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