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Article: PvuII polymorphisms of the estrogen receptor α and bone mineral density in healthy southern Chinese women

TitlePvuII polymorphisms of the estrogen receptor α and bone mineral density in healthy southern Chinese women
Authors
Issue Date2000
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223
Citation
Calcified Tissue International, 2000, v. 66 n. 6, p. 405-408 How to Cite?
AbstractThe association between PvuII polymorphisms of the estrogen receptor α (ERα) gene and total as well as regional bone mineral density (BMD) in healthy Chinese women (n = 182) was determined by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP), where P indicated the absence and p the presence of PvuII restriction sites. Subjects with PP genotype had significantly higher BMD at the thoracic spine and ribs (both P < 0.05) when compared with those with Pp and pp genotypes. Although PP genotype had slightly higher BMD values at the lumbar spine L2-L4 region and hip by 8% and 7%, respectively, the results failed to reach statistical significance. After adjusting for age, height, weight, and years since menopause, PP genotype had higher BMD at the left (P < 0.02) and right (P < 0.05) rib region but not at the thoracic spine (P = 0.056). Analyzing the premenopausal subjects alone (n = 64) revealed that subjects with PP genotype had higher adjusted BMD at the fight fib region (P < 0.05). When only the postmenopausal women (n = 118) were analyzed, the adjusted BMD of the PP genotype at the thoracic spine was significantly higher (P < 0.05) than the other two groups. In conclusion, estrogen receptor gene has a role in determining bone mass but the clinical impact on its own is probably small.
Persistent Identifierhttp://hdl.handle.net/10722/162428
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.166
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, AYYen_US
dc.contributor.authorYeung, SSCen_US
dc.contributor.authorKung, AWCen_US
dc.date.accessioned2012-09-05T05:19:49Z-
dc.date.available2012-09-05T05:19:49Z-
dc.date.issued2000en_US
dc.identifier.citationCalcified Tissue International, 2000, v. 66 n. 6, p. 405-408en_US
dc.identifier.issn0171-967Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/162428-
dc.description.abstractThe association between PvuII polymorphisms of the estrogen receptor α (ERα) gene and total as well as regional bone mineral density (BMD) in healthy Chinese women (n = 182) was determined by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP), where P indicated the absence and p the presence of PvuII restriction sites. Subjects with PP genotype had significantly higher BMD at the thoracic spine and ribs (both P < 0.05) when compared with those with Pp and pp genotypes. Although PP genotype had slightly higher BMD values at the lumbar spine L2-L4 region and hip by 8% and 7%, respectively, the results failed to reach statistical significance. After adjusting for age, height, weight, and years since menopause, PP genotype had higher BMD at the left (P < 0.02) and right (P < 0.05) rib region but not at the thoracic spine (P = 0.056). Analyzing the premenopausal subjects alone (n = 64) revealed that subjects with PP genotype had higher adjusted BMD at the fight fib region (P < 0.05). When only the postmenopausal women (n = 118) were analyzed, the adjusted BMD of the PP genotype at the thoracic spine was significantly higher (P < 0.05) than the other two groups. In conclusion, estrogen receptor gene has a role in determining bone mass but the clinical impact on its own is probably small.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223en_US
dc.relation.ispartofCalcified Tissue Internationalen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshEstrogen Receptor Alphaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHip - Radiographyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshPostmenopauseen_US
dc.subject.meshPremenopauseen_US
dc.subject.meshReceptors, Estrogen - Geneticsen_US
dc.subject.meshRibs - Radiographyen_US
dc.subject.meshSpine - Radiographyen_US
dc.titlePvuII polymorphisms of the estrogen receptor α and bone mineral density in healthy southern Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s002230010082en_US
dc.identifier.pmid10821874-
dc.identifier.scopuseid_2-s2.0-0034119854en_US
dc.identifier.hkuros51311-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034119854&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume66en_US
dc.identifier.issue6en_US
dc.identifier.spage405en_US
dc.identifier.epage408en_US
dc.identifier.isiWOS:000087248100002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, AYY=7402675209en_US
dc.identifier.scopusauthoridYeung, SSC=7102767673en_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US

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