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Article: A prospective study of survival and prognostic indicators of systemic lupus erythematosus in a southern Chinese population

TitleA prospective study of survival and prognostic indicators of systemic lupus erythematosus in a southern Chinese population
Authors
Issue Date2000
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology, 2000, v. 39 n. 4, p. 399-406 How to Cite?
AbstractObjectives. To study the survival rate and prognostic indicators of systemic lupus erythematosus (SLE) in a southern Chinese population. Methods. One hundred and eighty-six patients with SLE diagnosed between 1992 and 1999 were prospectively followed. Clinical features at presentation, subsequent evolving features, autoantibody profile, damage scores and mortality data were obtained. Prognostic factors for survival were studied by statistical analysis. Results. One hundred and sixty-three female and 23 male SLE patients were studied. The female to male ratio was 7.1 to 1 and the mean age at presentation was 33.6 yr (range 12-75). The mean disease duration was 45.2 months. At diagnosis, arthritis, malar rash and alopecia were the commonest features. During follow-up, the prevalence of nephritis, arthritis, photosensitivity and haematological disease increased significantly. Thirty-one per cent of the patients had organ damage at the time of data analysis and renal disease was the commonest cause. Logistic regression revealed that central nervous system disease, discoid lesions and treatment with high-dose steroid were independent predictors for damage. Nine patients died during the study period (three of disease-related complications and six of infections). The 3-, 5-, and 7-yr survival rates of our cohort were 97, 93 and 93%, respectively. Cox regression analysis revealed that thrombocytopenia and high-dose steroid treatment were independent risk factors for mortality. Conclusions. The survival of SLE in our southern Chinese patients is similar to that of the Caucasian series reported in the 1990s. Although nephritis contributes to organ damage, it is not a major determinant for survival. Infection remains the commonest cause of death. High-dose steroid treatment and thrombocytopenia are independent risk factors for mortality. Judicious use of immunosuppressive agents is necessary to improve the short-term survival of SLE.
Persistent Identifierhttp://hdl.handle.net/10722/162413
ISSN
2015 Impact Factor: 4.524
2015 SCImago Journal Rankings: 1.449
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, CCen_US
dc.contributor.authorLee, KWen_US
dc.contributor.authorHo, CTKen_US
dc.contributor.authorLau, CSen_US
dc.contributor.authorWong, RWSen_US
dc.date.accessioned2012-09-05T05:19:43Z-
dc.date.available2012-09-05T05:19:43Z-
dc.date.issued2000en_US
dc.identifier.citationRheumatology, 2000, v. 39 n. 4, p. 399-406en_US
dc.identifier.issn1462-0324en_US
dc.identifier.urihttp://hdl.handle.net/10722/162413-
dc.description.abstractObjectives. To study the survival rate and prognostic indicators of systemic lupus erythematosus (SLE) in a southern Chinese population. Methods. One hundred and eighty-six patients with SLE diagnosed between 1992 and 1999 were prospectively followed. Clinical features at presentation, subsequent evolving features, autoantibody profile, damage scores and mortality data were obtained. Prognostic factors for survival were studied by statistical analysis. Results. One hundred and sixty-three female and 23 male SLE patients were studied. The female to male ratio was 7.1 to 1 and the mean age at presentation was 33.6 yr (range 12-75). The mean disease duration was 45.2 months. At diagnosis, arthritis, malar rash and alopecia were the commonest features. During follow-up, the prevalence of nephritis, arthritis, photosensitivity and haematological disease increased significantly. Thirty-one per cent of the patients had organ damage at the time of data analysis and renal disease was the commonest cause. Logistic regression revealed that central nervous system disease, discoid lesions and treatment with high-dose steroid were independent predictors for damage. Nine patients died during the study period (three of disease-related complications and six of infections). The 3-, 5-, and 7-yr survival rates of our cohort were 97, 93 and 93%, respectively. Cox regression analysis revealed that thrombocytopenia and high-dose steroid treatment were independent risk factors for mortality. Conclusions. The survival of SLE in our southern Chinese patients is similar to that of the Caucasian series reported in the 1990s. Although nephritis contributes to organ damage, it is not a major determinant for survival. Infection remains the commonest cause of death. High-dose steroid treatment and thrombocytopenia are independent risk factors for mortality. Judicious use of immunosuppressive agents is necessary to improve the short-term survival of SLE.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/en_US
dc.relation.ispartofRheumatologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCause Of Deathen_US
dc.subject.meshChilden_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents - Adverse Effects - Therapeutic Useen_US
dc.subject.meshInfection - Mortalityen_US
dc.subject.meshLupus Erythematosus, Systemic - Complications - Mortalityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNephritis - Etiologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSteroids - Adverse Effects - Therapeutic Useen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshThrombocytopenia - Etiology - Mortalityen_US
dc.titleA prospective study of survival and prognostic indicators of systemic lupus erythematosus in a southern Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/rheumatology/39.4.399-
dc.identifier.pmid10817773-
dc.identifier.scopuseid_2-s2.0-0034028877en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034028877&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue4en_US
dc.identifier.spage399en_US
dc.identifier.epage406en_US
dc.identifier.isiWOS:000087299700011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMok, CC=34668219600en_US
dc.identifier.scopusauthoridLee, KW=35788977700en_US
dc.identifier.scopusauthoridHo, CTK=7404652632en_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US
dc.identifier.scopusauthoridWong, RWS=34875928200en_US

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