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Article: T cell tolerance and autoimmunity

TitleT cell tolerance and autoimmunity
Authors
Issue Date2000
PublisherBlackwell Munksgaard. The Journal's web site is located at http://journals.munksgaard.dk/reviewsimmunogenetics
Citation
Reviews In Immunogenetics, 2000, v. 2 n. 1, p. 2-17 How to Cite?
AbstractA functional immune system requires a T cell repertoire that is extremely diverse so as to allow for the elimination of all possible pathogens. However, the production of an immense T cell repertoire also increases the likelihood of generating autoreactive T cells. The immune system must therefore also incorporate a means of silencing or eliminating autoreactive T cells, while minimally sacrificing T cell diversity. The induction and maintenance of T cell unresponsiveness to self antigens is thus defined as T cell tolerance. This review provides an overview of the T cell tolerance mechanisms invoked in the thymus and in the periphery to prevent the induction of autoimmunity. Factors that can influence the induction of tolerance and autoimmunity are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/162410
ISSN
2003 SCImago Journal Rankings: 1.563

 

DC FieldValueLanguage
dc.contributor.authorGarza, KMen_US
dc.contributor.authorChan, VSFen_US
dc.contributor.authorOhashi, PSen_US
dc.date.accessioned2012-09-05T05:19:40Z-
dc.date.available2012-09-05T05:19:40Z-
dc.date.issued2000en_US
dc.identifier.citationReviews In Immunogenetics, 2000, v. 2 n. 1, p. 2-17en_US
dc.identifier.issn1398-1714en_US
dc.identifier.urihttp://hdl.handle.net/10722/162410-
dc.description.abstractA functional immune system requires a T cell repertoire that is extremely diverse so as to allow for the elimination of all possible pathogens. However, the production of an immense T cell repertoire also increases the likelihood of generating autoreactive T cells. The immune system must therefore also incorporate a means of silencing or eliminating autoreactive T cells, while minimally sacrificing T cell diversity. The induction and maintenance of T cell unresponsiveness to self antigens is thus defined as T cell tolerance. This review provides an overview of the T cell tolerance mechanisms invoked in the thymus and in the periphery to prevent the induction of autoimmunity. Factors that can influence the induction of tolerance and autoimmunity are also discussed.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://journals.munksgaard.dk/reviewsimmunogeneticsen_US
dc.relation.ispartofReviews in Immunogeneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAutoimmunity - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune Tolerance - Immunologyen_US
dc.subject.meshT-Lymphocytes - Immunologyen_US
dc.subject.meshThymus Gland - Immunologyen_US
dc.titleT cell tolerance and autoimmunityen_US
dc.typeArticleen_US
dc.identifier.emailChan, VSF:sfvchan@hku.hken_US
dc.identifier.authorityChan, VSF=rp01459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11324690-
dc.identifier.scopuseid_2-s2.0-0034009210en_US
dc.identifier.volume2en_US
dc.identifier.issue1en_US
dc.identifier.spage2en_US
dc.identifier.epage17en_US
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridGarza, KM=6603040504en_US
dc.identifier.scopusauthoridChan, VSF=35200370000en_US
dc.identifier.scopusauthoridOhashi, PS=7006493798en_US

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