File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: β-Adrenergic agonists and bronchial hyperreactivity: Role of β2- adrenergic and tachykinin neurokinin-2 receptors

Titleβ-Adrenergic agonists and bronchial hyperreactivity: Role of β2- adrenergic and tachykinin neurokinin-2 receptors
Authors
Issue Date2000
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jaci
Citation
Journal Of Allergy And Clinical Immunology, 2000, v. 106 n. 1 II, p. S104-S108 How to Cite?
AbstractBackground: β2-Adrenergic agonists are the most widely used bronchodilators for the treatment of asthma. On the other hand, there is concern that excessive use of β2-agonists may contribute to the exacerbation of asthma. However, the mechanism of such adverse effects of β2-agonists is not completely clear. Objective: The aim of this study was to assess the direct influence of β2-agonists on airways by analyzing the effect of a β2-agonist, fenoterol, on airway sensitivity in an animal model and on tachykinin neurokinin-2 receptor expression in bovine tracheal smooth muscle. Methods: We performed an acetylcholine challenge test on ovalbumin sensitized guinea pigs that were exposed to daily inhalation of ovalbumin and fenoterol. We also investigated the effects of fenoterol on neurokinin-2 receptor messenger RNA and density with Northern blot analysis and receptor binding assay. Result: The increase of airway responsiveness and the decrease of β2-adrenergic receptors were found in guinea pigs that were treated with fenoterol. There were time- and dose-dependent increases of neurokinin-2 receptor mRNA and of density in tracheal smooth muscle that was treated with fenoterol. Conclusion: This increased airway responsiveness, increased neurokinin-2 receptor expression, and decreased β2-adrenergic receptor density may be relevant to asthma exacerbation.
Persistent Identifierhttp://hdl.handle.net/10722/162400
ISSN
2015 Impact Factor: 12.485
2015 SCImago Journal Rankings: 5.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKatsunuma, Ten_US
dc.contributor.authorFujita, Ken_US
dc.contributor.authorMak, JCWen_US
dc.contributor.authorBarnes, PJen_US
dc.contributor.authorUeno, Ken_US
dc.contributor.authorIikura, Yen_US
dc.date.accessioned2012-09-05T05:19:36Z-
dc.date.available2012-09-05T05:19:36Z-
dc.date.issued2000en_US
dc.identifier.citationJournal Of Allergy And Clinical Immunology, 2000, v. 106 n. 1 II, p. S104-S108en_US
dc.identifier.issn0091-6749en_US
dc.identifier.urihttp://hdl.handle.net/10722/162400-
dc.description.abstractBackground: β2-Adrenergic agonists are the most widely used bronchodilators for the treatment of asthma. On the other hand, there is concern that excessive use of β2-agonists may contribute to the exacerbation of asthma. However, the mechanism of such adverse effects of β2-agonists is not completely clear. Objective: The aim of this study was to assess the direct influence of β2-agonists on airways by analyzing the effect of a β2-agonist, fenoterol, on airway sensitivity in an animal model and on tachykinin neurokinin-2 receptor expression in bovine tracheal smooth muscle. Methods: We performed an acetylcholine challenge test on ovalbumin sensitized guinea pigs that were exposed to daily inhalation of ovalbumin and fenoterol. We also investigated the effects of fenoterol on neurokinin-2 receptor messenger RNA and density with Northern blot analysis and receptor binding assay. Result: The increase of airway responsiveness and the decrease of β2-adrenergic receptors were found in guinea pigs that were treated with fenoterol. There were time- and dose-dependent increases of neurokinin-2 receptor mRNA and of density in tracheal smooth muscle that was treated with fenoterol. Conclusion: This increased airway responsiveness, increased neurokinin-2 receptor expression, and decreased β2-adrenergic receptor density may be relevant to asthma exacerbation.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacien_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.subject.meshAdrenergic Beta-Agonists - Adverse Effects - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAsthma - Mortalityen_US
dc.subject.meshBronchial Hyperreactivity - Chemically Induced - Physiopathologyen_US
dc.subject.meshCattleen_US
dc.subject.meshFenoterol - Adverse Effects - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth - Drug Effectsen_US
dc.subject.meshReceptors, Adrenergic, Beta-2 - Physiologyen_US
dc.subject.meshReceptors, Neurokinin-2 - Physiologyen_US
dc.subject.meshTrachea - Drug Effectsen_US
dc.titleβ-Adrenergic agonists and bronchial hyperreactivity: Role of β2- adrenergic and tachykinin neurokinin-2 receptorsen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1067/mai.2000.106636-
dc.identifier.pmid10887342-
dc.identifier.scopuseid_2-s2.0-0033940028en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033940028&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume106en_US
dc.identifier.issue1 IIen_US
dc.identifier.spageS104en_US
dc.identifier.epageS108en_US
dc.identifier.isiWOS:000088482600015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKatsunuma, T=7004760540en_US
dc.identifier.scopusauthoridFujita, K=7404058301en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridBarnes, PJ=36064679400en_US
dc.identifier.scopusauthoridUeno, K=7403134130en_US
dc.identifier.scopusauthoridIikura, Y=7102513516en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats