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Article: Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer

TitleMicrosatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer
Authors
Issue Date2000
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 2000, v. 156 n. 2, p. 537-543 How to Cite?
AbstractThe role and significance of microsatellite instability (MSI) in gastric carcinogenesis remain unknown. This study determined the chronology of MSI in gastric carcinogenesis by examining intestinal metaplasia (IM) from patients with and without gastric cancer. DNA was obtained from gastric specimens of 75 patients with gastric IM (30 cancer, 26 peptic ulcer, and 19 chronic gastritis patients) and was amplified with a set of eight microsatellite markers. Eight (26.7%) tumors and seven (9.3%) IM samples (three from cancer-free patients) displayed high-level MSI (three or more loci altered). Low-level MSI (one or two loci altered) was detected in 50% of the tumors, in 40% of IM samples coexisting with cancer, and in 38% of IM tissues of cancer-free individuals. Among the 30 cancer patients, microsatellites were more frequently altered in IM coexisting with tumors that showed MSI (P = 0.003). In addition, patients with low-level MSI in the tumor tissues were more likely to have active Helicobacter pylori infection than those with stable tumors (P = 0.02). In conclusion, this study indicates that MSI occurs not only in gastric IM of patients with gastric carcinoma, but also in IM of cancer-free individuals. These data suggest that the progressive accumulation of MSI in areas of IM may contribute to gastric cancer development, representing an important molecular event in the multistep gastric carcinogenesis cascade.
Persistent Identifierhttp://hdl.handle.net/10722/162393
ISSN
2015 Impact Factor: 4.206
2015 SCImago Journal Rankings: 2.653
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WKen_US
dc.contributor.authorKim, JJen_US
dc.contributor.authorKim, JGen_US
dc.contributor.authorGraham, DYen_US
dc.contributor.authorSepulveda, ARen_US
dc.date.accessioned2012-09-05T05:19:33Z-
dc.date.available2012-09-05T05:19:33Z-
dc.date.issued2000en_US
dc.identifier.citationAmerican Journal Of Pathology, 2000, v. 156 n. 2, p. 537-543en_US
dc.identifier.issn0002-9440en_US
dc.identifier.urihttp://hdl.handle.net/10722/162393-
dc.description.abstractThe role and significance of microsatellite instability (MSI) in gastric carcinogenesis remain unknown. This study determined the chronology of MSI in gastric carcinogenesis by examining intestinal metaplasia (IM) from patients with and without gastric cancer. DNA was obtained from gastric specimens of 75 patients with gastric IM (30 cancer, 26 peptic ulcer, and 19 chronic gastritis patients) and was amplified with a set of eight microsatellite markers. Eight (26.7%) tumors and seven (9.3%) IM samples (three from cancer-free patients) displayed high-level MSI (three or more loci altered). Low-level MSI (one or two loci altered) was detected in 50% of the tumors, in 40% of IM samples coexisting with cancer, and in 38% of IM tissues of cancer-free individuals. Among the 30 cancer patients, microsatellites were more frequently altered in IM coexisting with tumors that showed MSI (P = 0.003). In addition, patients with low-level MSI in the tumor tissues were more likely to have active Helicobacter pylori infection than those with stable tumors (P = 0.02). In conclusion, this study indicates that MSI occurs not only in gastric IM of patients with gastric carcinoma, but also in IM of cancer-free individuals. These data suggest that the progressive accumulation of MSI in areas of IM may contribute to gastric cancer development, representing an important molecular event in the multistep gastric carcinogenesis cascade.en_US
dc.languageengen_US
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_US
dc.relation.ispartofAmerican Journal of Pathologyen_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma - Genetics - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestines - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMetaplasiaen_US
dc.subject.meshMicrosatellite Repeatsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshStomach - Pathologyen_US
dc.subject.meshStomach Neoplasms - Genetics - Pathologyen_US
dc.titleMicrosatellite instability in gastric intestinal metaplasia in patients with and without gastric canceren_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0002-9440(10)64758-X-
dc.identifier.pmid10666383-
dc.identifier.scopuseid_2-s2.0-0033870284en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033870284&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume156en_US
dc.identifier.issue2en_US
dc.identifier.spage537en_US
dc.identifier.epage543en_US
dc.identifier.isiWOS:000085296500021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridKim, JJ=36067967700en_US
dc.identifier.scopusauthoridKim, JG=34771414000en_US
dc.identifier.scopusauthoridGraham, DY=7403477677en_US
dc.identifier.scopusauthoridSepulveda, AR=35500186600en_US

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