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Article: Quantitative ultrasound and symptomatic vertebral fracture risk in Chinese women

TitleQuantitative ultrasound and symptomatic vertebral fracture risk in Chinese women
Authors
Issue Date1999
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 1999, v. 10 n. 6, p. 456-461 How to Cite?
AbstractQuantitative ultrasound (QUS) is emerging as a simple, inexpensive and noninvasive method for assessing bone quality and assessing fracture risk. We assessed the usefulness of a contact calcaneal ultrasonometer by studying normal premenopausal women (group I, n = 53), normal postmenopausal women (group II, n = 198), and osteoporotic women without (group III, n = 141) and with vertebral fractures (group IV, n = 53). The osteoporotic subjects had a T-score of the spine or hip neck bone mineral density (BMD) < -2.5 based on the local Chinese peak young mean values. When compared with postmenopausal controls, mean broadband ultrasound attenuation (BUA), speed of sound (SOS), and quantitative ultrasound index (QUI) were 26%, 2.1% and 25% lower in women with vertebral fractures (p all < 0.095). The correlation coefficients between QUS parameters and BMD of the spine and hip ranged between 0.4 and 0.5. The ability of the QUS to discriminate between patients groups was determined based on the mean value of normal premenopausal women in group I. The mean T-score for women with fractures was -2.87 ± 1.02 for BUA, -2.54 ± 0.79 for SOS, -3.17 ± 0.70 for QUI, -2.65 ± 0.86 for L2-4, BMD and -2.53 ± 0.66 for hip neck BMD. After adjustment for age and body mass index, the odds ratio of vertebral fracture was 1.71 (95% CI 1.2-2.6) for each 1 SD reduction in BUA, 2.72 (1.3-5.3) for SOS, 2.58 (1.4-4.6) for QUI, 2.33 (1.6-3.3) for L2-4 BMD, 2.09 (1.37-3.20) for femoral neck BMD and 1.88 (1.34-2.92) for total hip BMD. The association between the QUS parameters and vertebral fracture risk persisted even adjustment for BMD. The area under the receiver operating characteristic curve for BUA for vertebral fracture was 0.92, for SOS, QUI, L2-4 BMD and femoral neck BMD was 0.95, and for total hip was 0.91.
Persistent Identifierhttp://hdl.handle.net/10722/162360
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorChu, LWen_US
dc.contributor.authorTang, GWKen_US
dc.date.accessioned2012-09-05T05:19:16Z-
dc.date.available2012-09-05T05:19:16Z-
dc.date.issued1999en_US
dc.identifier.citationOsteoporosis International, 1999, v. 10 n. 6, p. 456-461en_US
dc.identifier.issn0937-941Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/162360-
dc.description.abstractQuantitative ultrasound (QUS) is emerging as a simple, inexpensive and noninvasive method for assessing bone quality and assessing fracture risk. We assessed the usefulness of a contact calcaneal ultrasonometer by studying normal premenopausal women (group I, n = 53), normal postmenopausal women (group II, n = 198), and osteoporotic women without (group III, n = 141) and with vertebral fractures (group IV, n = 53). The osteoporotic subjects had a T-score of the spine or hip neck bone mineral density (BMD) < -2.5 based on the local Chinese peak young mean values. When compared with postmenopausal controls, mean broadband ultrasound attenuation (BUA), speed of sound (SOS), and quantitative ultrasound index (QUI) were 26%, 2.1% and 25% lower in women with vertebral fractures (p all < 0.095). The correlation coefficients between QUS parameters and BMD of the spine and hip ranged between 0.4 and 0.5. The ability of the QUS to discriminate between patients groups was determined based on the mean value of normal premenopausal women in group I. The mean T-score for women with fractures was -2.87 ± 1.02 for BUA, -2.54 ± 0.79 for SOS, -3.17 ± 0.70 for QUI, -2.65 ± 0.86 for L2-4, BMD and -2.53 ± 0.66 for hip neck BMD. After adjustment for age and body mass index, the odds ratio of vertebral fracture was 1.71 (95% CI 1.2-2.6) for each 1 SD reduction in BUA, 2.72 (1.3-5.3) for SOS, 2.58 (1.4-4.6) for QUI, 2.33 (1.6-3.3) for L2-4 BMD, 2.09 (1.37-3.20) for femoral neck BMD and 1.88 (1.34-2.92) for total hip BMD. The association between the QUS parameters and vertebral fracture risk persisted even adjustment for BMD. The area under the receiver operating characteristic curve for BUA for vertebral fracture was 0.92, for SOS, QUI, L2-4 BMD and femoral neck BMD was 0.95, and for total hip was 0.91.en_US
dc.languageengen_US
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_US
dc.relation.ispartofOsteoporosis Internationalen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAdulten_US
dc.subject.meshArea Under Curveen_US
dc.subject.meshBone Density - Physiologyen_US
dc.subject.meshChinaen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshOsteoporosis, Postmenopausal - Physiopathology - Ultrasonographyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPremenopause - Physiologyen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSpinal Fractures - Physiopathology - Ultrasonographyen_US
dc.titleQuantitative ultrasound and symptomatic vertebral fracture risk in Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.emailTang, GWK:gwktang@hkucc.hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityTang, GWK=rp00328en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s001980050254en_US
dc.identifier.pmid10663345-
dc.identifier.scopuseid_2-s2.0-0033382076en_US
dc.identifier.hkuros51248-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033382076&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue6en_US
dc.identifier.spage456en_US
dc.identifier.epage461en_US
dc.identifier.isiWOS:000084862900004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US
dc.identifier.scopusauthoridChu, LW=7202236665en_US
dc.identifier.scopusauthoridTang, GWK=7401633864en_US

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