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Article: Effect of radioactive iodine therapy on cytokine production in Graves' disease: Transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-α, with longer term increases in interferon-γ production

TitleEffect of radioactive iodine therapy on cytokine production in Graves' disease: Transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-α, with longer term increases in interferon-γ production
Authors
Issue Date1999
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 1999, v. 84 n. 11, p. 4106-4110 How to Cite?
AbstractSpontaneous and mitogen-stimulated production of interleukin-4 (IL-4), IL-6, IL-10, IL-12, interferon-γ (IFNγ), and tumor necrosis factor-α were evaluated by enzyme-linked immunospot assay of peripheral blood mononuclear cells from patients with Graves' disease immediately before and at 4, 17, and 59 days after treatment with radioactive iodine. Patients had significantly reduced IL-4 and IFNγ production before treatment compared with healthy controls. Both cytokines were increased to normal levels by day 17 after treatment, and IFNγ remained at normal levels on day 59, whereas IL-4 returned to subnorma levels at this time. IL-12 production was initially normal and was not significantly altered by therapy. IL-6, IL-10, and tumor necrosis factor-α were also normal before radiotherapy, but increased significantly on day 17, returning to pretreatment levels by day 59. Thus, radioiodine treatment induced a transient increase in both proinflammatory and antiinflammatory cytokines and a more prolonged increase in IFNγ production, the latter representing a definite shift toward a type 1 cytokine profile.
Persistent Identifierhttp://hdl.handle.net/10722/162358
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJones, BMen_US
dc.contributor.authorKwok, CCHen_US
dc.contributor.authorKung, AWCen_US
dc.date.accessioned2012-09-05T05:19:16Z-
dc.date.available2012-09-05T05:19:16Z-
dc.date.issued1999en_US
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1999, v. 84 n. 11, p. 4106-4110en_US
dc.identifier.issn0021-972Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/162358-
dc.description.abstractSpontaneous and mitogen-stimulated production of interleukin-4 (IL-4), IL-6, IL-10, IL-12, interferon-γ (IFNγ), and tumor necrosis factor-α were evaluated by enzyme-linked immunospot assay of peripheral blood mononuclear cells from patients with Graves' disease immediately before and at 4, 17, and 59 days after treatment with radioactive iodine. Patients had significantly reduced IL-4 and IFNγ production before treatment compared with healthy controls. Both cytokines were increased to normal levels by day 17 after treatment, and IFNγ remained at normal levels on day 59, whereas IL-4 returned to subnorma levels at this time. IL-12 production was initially normal and was not significantly altered by therapy. IL-6, IL-10, and tumor necrosis factor-α were also normal before radiotherapy, but increased significantly on day 17, returning to pretreatment levels by day 59. Thus, radioiodine treatment induced a transient increase in both proinflammatory and antiinflammatory cytokines and a more prolonged increase in IFNγ production, the latter representing a definite shift toward a type 1 cytokine profile.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_US
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAutoantibodies - Blooden_US
dc.subject.meshCytokines - Biosynthesisen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraves Disease - Metabolism - Radiotherapyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism - Etiologyen_US
dc.subject.meshImmunoglobulins, Thyroid-Stimulatingen_US
dc.subject.meshInterferon-Gamma - Biosynthesisen_US
dc.subject.meshInterleukin-10 - Biosynthesisen_US
dc.subject.meshInterleukin-4 - Biosynthesisen_US
dc.subject.meshInterleukin-6 - Biosynthesisen_US
dc.subject.meshIodine Radioisotopes - Adverse Effects - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptors, Thyrotropin - Blooden_US
dc.subject.meshThyrotropin - Blooden_US
dc.subject.meshThyroxine - Blooden_US
dc.subject.meshTumor Necrosis Factor-Alpha - Biosynthesisen_US
dc.titleEffect of radioactive iodine therapy on cytokine production in Graves' disease: Transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-α, with longer term increases in interferon-γ productionen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1210/jc.84.11.4106-
dc.identifier.pmid10566657-
dc.identifier.scopuseid_2-s2.0-0033329862en_US
dc.identifier.hkuros51309-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033329862&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume84en_US
dc.identifier.issue11en_US
dc.identifier.spage4106en_US
dc.identifier.epage4110en_US
dc.identifier.isiWOS:000083555800038-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJones, BM=7404958958en_US
dc.identifier.scopusauthoridKwok, CCH=7102029180en_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US

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