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Article: Trisomy 22 in acute myeloid leukemia: A marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16

TitleTrisomy 22 in acute myeloid leukemia: A marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16
Authors
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1999, v. 109 n. 2, p. 131-133 How to Cite?
AbstractTrisomy 22 is an uncommon chromosomal abnormality in acute myeloid leukemia. Recent studies, however, have shown an association between trisomy 22 and acute myeloid leukemia with a monocytic component, and in particular, acute myelomonocytic leukemia with marrow eosinophilia. Furthermore, it has also been suggested that trisomy 22 was in fact only a secondary chromosomal change occurring in acute myeloid leukemia with inv(16). In this report, we analyze the morphological, cytogenetic, and molecular findings of three cases of acute myeloid leukemia with trisomy 22 but without cytogenetic evidence of inv(16). The results indicate a consistent association between trisomy 22 and inv(16), the latter being cytogenetically cryptic in some cases. This finding is of potential diagnostic and therapeutic significance.
Persistent Identifierhttp://hdl.handle.net/10722/162344
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:19:09Z-
dc.date.available2012-09-05T05:19:09Z-
dc.date.issued1999en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1999, v. 109 n. 2, p. 131-133en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162344-
dc.description.abstractTrisomy 22 is an uncommon chromosomal abnormality in acute myeloid leukemia. Recent studies, however, have shown an association between trisomy 22 and acute myeloid leukemia with a monocytic component, and in particular, acute myelomonocytic leukemia with marrow eosinophilia. Furthermore, it has also been suggested that trisomy 22 was in fact only a secondary chromosomal change occurring in acute myeloid leukemia with inv(16). In this report, we analyze the morphological, cytogenetic, and molecular findings of three cases of acute myeloid leukemia with trisomy 22 but without cytogenetic evidence of inv(16). The results indicate a consistent association between trisomy 22 and inv(16), the latter being cytogenetically cryptic in some cases. This finding is of potential diagnostic and therapeutic significance.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChromosome Inversionen_US
dc.subject.meshChromosomes, Human, Pair 16en_US
dc.subject.meshChromosomes, Human, Pair 22en_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMonocytes - Pathologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshTrisomyen_US
dc.titleTrisomy 22 in acute myeloid leukemia: A marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16en_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(98)00145-9en_US
dc.identifier.pmid10087946en_US
dc.identifier.scopuseid_2-s2.0-0033059033en_US
dc.identifier.hkuros41952-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033059033&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume109en_US
dc.identifier.issue2en_US
dc.identifier.spage131en_US
dc.identifier.epage133en_US
dc.identifier.isiWOS:000079049200008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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