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Article: Heterogeneous changes in electrophysiologic properties in the paroxysmal and chronically fibrillating human atrium

TitleHeterogeneous changes in electrophysiologic properties in the paroxysmal and chronically fibrillating human atrium
Authors
Issue Date1999
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873
Citation
Journal Of Cardiovascular Electrophysiology, 1999, v. 10 n. 2, p. 125-135 How to Cite?
AbstractHeterogeneous Changes in Atrial Electrophysiologic Properties. Introduction: The regional changes in atrial electrophysiologic properties related to atrial fibrillation (AF) in patients with paroxysmal AF (PAF) and chronic AF (CAF) remain unclear. The purpose of this study was to investigate the regional changes in atrial electrophysiology in patients with AF. Methods and Results; We evaluated the atrial electrophysiology at different sites (high right atrium, low right atrium [LRA], and distal coronary sinus [DCS]) in 11 patients with CAF, 8 patients with PAF, and 10 controls. Patients with CAF had significantly prolonged interatrial conduction and corrected sinus node recovery time, and shortened atrial effective refractory period (ERP) with loss of rate-related adaptation in the DCS, but had paradoxic prolongation of atrial ERP in the LRA, as compared with patients with PAF and the controls. As a result, the spatial distribution of atrial ERP that was observed in the controls and in patients with PAF was reversed in patients with CAF, without an increase in the dispersion of atrial refractoriness. Patients with PAF showed intermediate changes in atrial conduction times and atrial refractoriness as compared with patients with CAF and controls. Conclusion: There was a regional heterogeneity on the changes of atrial electrophysiology in different parts of the atrium, and the 'normal' spatial distribution of atrial refractoriness was reversed in patients with CAF. The electrophysiologic changes observed in patients with PAF appear to behave as if in transition from the control state to CAF, suggesting progressive changes in atrial electrophysiologic properties.
Persistent Identifierhttp://hdl.handle.net/10722/162334
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 1.863
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorAyers, GMen_US
dc.date.accessioned2012-09-05T05:19:05Z-
dc.date.available2012-09-05T05:19:05Z-
dc.date.issued1999en_US
dc.identifier.citationJournal Of Cardiovascular Electrophysiology, 1999, v. 10 n. 2, p. 125-135en_US
dc.identifier.issn1045-3873en_US
dc.identifier.urihttp://hdl.handle.net/10722/162334-
dc.description.abstractHeterogeneous Changes in Atrial Electrophysiologic Properties. Introduction: The regional changes in atrial electrophysiologic properties related to atrial fibrillation (AF) in patients with paroxysmal AF (PAF) and chronic AF (CAF) remain unclear. The purpose of this study was to investigate the regional changes in atrial electrophysiology in patients with AF. Methods and Results; We evaluated the atrial electrophysiology at different sites (high right atrium, low right atrium [LRA], and distal coronary sinus [DCS]) in 11 patients with CAF, 8 patients with PAF, and 10 controls. Patients with CAF had significantly prolonged interatrial conduction and corrected sinus node recovery time, and shortened atrial effective refractory period (ERP) with loss of rate-related adaptation in the DCS, but had paradoxic prolongation of atrial ERP in the LRA, as compared with patients with PAF and the controls. As a result, the spatial distribution of atrial ERP that was observed in the controls and in patients with PAF was reversed in patients with CAF, without an increase in the dispersion of atrial refractoriness. Patients with PAF showed intermediate changes in atrial conduction times and atrial refractoriness as compared with patients with CAF and controls. Conclusion: There was a regional heterogeneity on the changes of atrial electrophysiology in different parts of the atrium, and the 'normal' spatial distribution of atrial refractoriness was reversed in patients with CAF. The electrophysiologic changes observed in patients with PAF appear to behave as if in transition from the control state to CAF, suggesting progressive changes in atrial electrophysiologic properties.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1045-3873en_US
dc.relation.ispartofJournal of Cardiovascular Electrophysiologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAtrial Fibrillation - Diagnosis - Physiopathology - Therapyen_US
dc.subject.meshBundle Of His - Physiopathologyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshElectric Countershocken_US
dc.subject.meshElectrocardiography, Ambulatoryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHeart Atria - Physiopathologyen_US
dc.subject.meshHeart Rateen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRadiography, Thoracicen_US
dc.subject.meshSinoatrial Node - Physiopathologyen_US
dc.subject.meshTachycardia, Paroxysmal - Diagnosis - Physiopathology - Therapyen_US
dc.titleHeterogeneous changes in electrophysiologic properties in the paroxysmal and chronically fibrillating human atriumen_US
dc.typeArticleen_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1540-8167.1999.tb00653.x-
dc.identifier.pmid10090215-
dc.identifier.scopuseid_2-s2.0-0033007807en_US
dc.identifier.hkuros40556-
dc.identifier.hkuros41426-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033007807&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue2en_US
dc.identifier.spage125en_US
dc.identifier.epage135en_US
dc.identifier.isiWOS:000078964600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US
dc.identifier.scopusauthoridAyers, GM=7102015157en_US

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