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Article: Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia

TitleLow frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia
Authors
Issue Date1999
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
Citation
Genes Chromosomes And Cancer, 1999, v. 25 n. 1, p. 70-74 How to Cite?
AbstractTranslocation (7;11)(p15;p15) is uncommon in acute myeloid leukemia (AML) and may have a predilection to occur in Asian patients. It results in a reciprocal fusion of the homeobox gene HOXA9 and the nucleoporin gene NUP98. To ascertain the molecular features and the clinicopathological and prognostic significance of t(7;11)(p15;p15), 208 adult Chinese patients with AML were screened by Southern blot analysis with an HOXA9 cDNA probe and reverse transcription-polymerase chain reaction for NUP98/HOXA9. Three cases were found to have rearrangement of the HOXA9 gene. Two cases were found to have an NUP98/HOXA9 fusion transcript, with a breakpoint at NUP98 different from that previously described. The remaining case had no rearrangement of NUP98, nor was NUP98/HOXA9 detected. All positive cases had refractory AML with poor treatment outcome. In conclusion, t(7;11)/HOXA9 rearrangement was a rare event (3/208, 1.5%) in AML, even in a population where it was considered to be more prevalent. Two breakpoints in NUP98 may occur, and this is of importance in the design of primers to amplify t(7;11).
Persistent Identifierhttp://hdl.handle.net/10722/162313
ISSN
2015 Impact Factor: 3.96
2015 SCImago Journal Rankings: 2.210
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.contributor.authorPang, Aen_US
dc.date.accessioned2012-09-05T05:18:53Z-
dc.date.available2012-09-05T05:18:53Z-
dc.date.issued1999en_US
dc.identifier.citationGenes Chromosomes And Cancer, 1999, v. 25 n. 1, p. 70-74en_US
dc.identifier.issn1045-2257en_US
dc.identifier.urihttp://hdl.handle.net/10722/162313-
dc.description.abstractTranslocation (7;11)(p15;p15) is uncommon in acute myeloid leukemia (AML) and may have a predilection to occur in Asian patients. It results in a reciprocal fusion of the homeobox gene HOXA9 and the nucleoporin gene NUP98. To ascertain the molecular features and the clinicopathological and prognostic significance of t(7;11)(p15;p15), 208 adult Chinese patients with AML were screened by Southern blot analysis with an HOXA9 cDNA probe and reverse transcription-polymerase chain reaction for NUP98/HOXA9. Three cases were found to have rearrangement of the HOXA9 gene. Two cases were found to have an NUP98/HOXA9 fusion transcript, with a breakpoint at NUP98 different from that previously described. The remaining case had no rearrangement of NUP98, nor was NUP98/HOXA9 detected. All positive cases had refractory AML with poor treatment outcome. In conclusion, t(7;11)/HOXA9 rearrangement was a rare event (3/208, 1.5%) in AML, even in a population where it was considered to be more prevalent. Two breakpoints in NUP98 may occur, and this is of importance in the design of primers to amplify t(7;11).en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250en_US
dc.relation.ispartofGenes Chromosomes and Canceren_US
dc.rightsGenes, Chromosomes & Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChromosomes, Human, Pair 11 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 7 - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenes, Homeobox - Geneticsen_US
dc.subject.meshHomeodomain Proteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid, Acute - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasm Proteins - Geneticsen_US
dc.subject.meshTranslocation, Genetic - Geneticsen_US
dc.titleLow frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1098-2264(199905)25:1<70::AID-GCC11>3.0.CO;2-Een_US
dc.identifier.pmid10221343-
dc.identifier.scopuseid_2-s2.0-0032911265en_US
dc.identifier.hkuros41972-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032911265&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue1en_US
dc.identifier.spage70en_US
dc.identifier.epage74en_US
dc.identifier.isiWOS:000079575500011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridPang, A=7007044165en_US

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