File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Seroprevalence of cytotoxin-associated gene A positive Helicobacter pylori strains in Changle, an area with very high prevalence of gastric cancel in South China

TitleSeroprevalence of cytotoxin-associated gene A positive Helicobacter pylori strains in Changle, an area with very high prevalence of gastric cancel in South China
Authors
Issue Date1999
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 1999, v. 13 n. 10, p. 1295-1302 How to Cite?
AbstractBackground: Helicobacter pylori, especially the CagA-positive strains, are closely associated with peptic ulcers and gastric cancers. We performed a large scale gastric cancer screening project and examined the prevalence of H. pylori and CagA-positive strains in Changle, China, an area with one of the World's highest gastric cancer mortality. We also compared the prevalence with that in Hong Kong which has one-tenth of the gastric cancer mortality of that in Changle. Methods: A total of 2424 subjects in Changle and 523 subjects in Hong Kong had endoscopic examination and venesection. Sera were tested for anti-H. pylori antibody and anti-CagA antibody and correlated with endoscopic findings. Results: In Changle, 80.9% of the subjects were H. pylori carriers. Out of 551 carriers, 408 (74%) were positive for anti-CagA antibody. A total of 76% and 87% of the asymptomatic and gastric cancer patients were positive for anti-CagA antibody, respectively (P > 0.05). Compared to Hong Kong, there was a significantly (P < 0.0001) higher prevalence of CagA-positive strains in asymptomatic subjects in Changle (76%) than in Hong Kong (28%), but not in peptic ulcers or gastric cancers. Conclusions: Subjects in Changle had a high prevalence of H. pylori infection and a high prevalence of the CagA-positive strains. The contrast in the prevalence of CagA-positive strains, in asymptomatic subjects in two areas with differing gastric cancer mortality, supports the pathogenic role of CagA-positive strains in gastric carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/162305
ISSN
2021 Impact Factor: 9.524
2020 SCImago Journal Rankings: 3.308
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorChing, CKen_US
dc.contributor.authorHu, WHCen_US
dc.contributor.authorOng, LYen_US
dc.contributor.authorChen, BWen_US
dc.contributor.authorGao, Zen_US
dc.contributor.authorChen, JSen_US
dc.contributor.authorJiang, XWen_US
dc.contributor.authorHou, XHen_US
dc.contributor.authorLu, JYen_US
dc.contributor.authorWang, WHen_US
dc.contributor.authorHo, Jen_US
dc.contributor.authorYuen, STen_US
dc.contributor.authorLai, KCen_US
dc.contributor.authorKwok, Een_US
dc.contributor.authorHui, WMen_US
dc.contributor.authorCovacci, Aen_US
dc.date.accessioned2012-09-05T05:18:47Z-
dc.date.available2012-09-05T05:18:47Z-
dc.date.issued1999en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 1999, v. 13 n. 10, p. 1295-1302en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/162305-
dc.description.abstractBackground: Helicobacter pylori, especially the CagA-positive strains, are closely associated with peptic ulcers and gastric cancers. We performed a large scale gastric cancer screening project and examined the prevalence of H. pylori and CagA-positive strains in Changle, China, an area with one of the World's highest gastric cancer mortality. We also compared the prevalence with that in Hong Kong which has one-tenth of the gastric cancer mortality of that in Changle. Methods: A total of 2424 subjects in Changle and 523 subjects in Hong Kong had endoscopic examination and venesection. Sera were tested for anti-H. pylori antibody and anti-CagA antibody and correlated with endoscopic findings. Results: In Changle, 80.9% of the subjects were H. pylori carriers. Out of 551 carriers, 408 (74%) were positive for anti-CagA antibody. A total of 76% and 87% of the asymptomatic and gastric cancer patients were positive for anti-CagA antibody, respectively (P > 0.05). Compared to Hong Kong, there was a significantly (P < 0.0001) higher prevalence of CagA-positive strains in asymptomatic subjects in Changle (76%) than in Hong Kong (28%), but not in peptic ulcers or gastric cancers. Conclusions: Subjects in Changle had a high prevalence of H. pylori infection and a high prevalence of the CagA-positive strains. The contrast in the prevalence of CagA-positive strains, in asymptomatic subjects in two areas with differing gastric cancer mortality, supports the pathogenic role of CagA-positive strains in gastric carcinogenesis.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies, Bacterial - Blooden_US
dc.subject.meshAntigens, Bacterialen_US
dc.subject.meshBacterial Proteins - Genetics - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Blood - Epidemiology - Microbiologyen_US
dc.subject.meshHelicobacter Pylori - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screeningen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshStomach Neoplasms - Blood - Epidemiology - Microbiologyen_US
dc.titleSeroprevalence of cytotoxin-associated gene A positive Helicobacter pylori strains in Changle, an area with very high prevalence of gastric cancel in South Chinaen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2036.1999.00619.xen_US
dc.identifier.pmid10540043-
dc.identifier.scopuseid_2-s2.0-0032849488en_US
dc.identifier.hkuros50512-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032849488&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue10en_US
dc.identifier.spage1295en_US
dc.identifier.epage1302en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridChing, CK=7102130825en_US
dc.identifier.scopusauthoridHu, WHC=25932937100en_US
dc.identifier.scopusauthoridOng, LY=8091873900en_US
dc.identifier.scopusauthoridChen, BW=7408610379en_US
dc.identifier.scopusauthoridGao, Z=19733331900en_US
dc.identifier.scopusauthoridChen, JS=8403980500en_US
dc.identifier.scopusauthoridJiang, XW=7404627650en_US
dc.identifier.scopusauthoridHou, XH=7402838898en_US
dc.identifier.scopusauthoridLu, JY=35225876600en_US
dc.identifier.scopusauthoridWang, WH=23390847100en_US
dc.identifier.scopusauthoridHo, J=15029093800en_US
dc.identifier.scopusauthoridYuen, ST=7103160927en_US
dc.identifier.scopusauthoridLai, KC=7402135595en_US
dc.identifier.scopusauthoridKwok, E=7005571440en_US
dc.identifier.scopusauthoridHui, WM=7103196477en_US
dc.identifier.scopusauthoridCovacci, A=7003304561en_US
dc.identifier.issnl0269-2813-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats