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Article: Lupus nephritis in southern Chinese patients: Clinicopathologic findings and long-term outcome

TitleLupus nephritis in southern Chinese patients: Clinicopathologic findings and long-term outcome
Authors
Issue Date1999
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American Journal Of Kidney Diseases, 1999, v. 34 n. 2, p. 315-323 How to Cite?
AbstractDespite the improvement in survival of patients with systemic lupus erythematosus (SLE) and associated nephritis in the past 20 years, few studies of the long-term outcome of large cohorts of patients with well- defined histological classes of lupus nephropathy are available. We examined the long-term outcome of 183 patients with lupus nephritis (LN) followed up by the Division of Rheumatology at Queen Mary Hospital (Hong Kong) between 1976 and 1997. Their renal biopsies were classified according to World Health Organization (WHO) criteria. There were 27 men and 156 women. Initial renal biopsy showed the following WHO classes of LN: 2 patients (1%), class I; 9 patients (5%), class II; 46 patients (25%), class III; 101 patients (55%), class IV; and 25 patients (14%), class V. The mean duration of follow-up from the renal biopsy was 130.7 ± 5.9 months (range, 13 to 260 months). The overall 5-, 10-, and 15-year survival and renal survival (survival without dialysis) rates were 98.9%, 94.4%, and 94.4% and 92.1%, 81.2%, and 75.2%, respectively. Univariate analysis showed class IV nephritis, hypertension, impaired renal function (glomerular filtration rate < 50 mL/min), nephrotic syndrome at time of renal biopsy, and failure of complete remission in the first year of treatment were unfavorable predictors for renal survival. Multivariate analysis using the Cox regression model also showed persistent hypertension, class IV nephritis, and incomplete renal remission in the first year were independent risk factors for renal failure. Our results showed the renal survival rate of our patients from South China with LN was similar to that of most reported series of white patients. Prospective randomized studies with well-defined treatment protocols are needed to delineate the optimal treatment strategy for LN.
Persistent Identifierhttp://hdl.handle.net/10722/162296
ISSN
2015 Impact Factor: 6.269
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChi Chiu Moken_US
dc.contributor.authorWong, RWSen_US
dc.contributor.authorChak Sing Lauen_US
dc.date.accessioned2012-09-05T05:18:43Z-
dc.date.available2012-09-05T05:18:43Z-
dc.date.issued1999en_US
dc.identifier.citationAmerican Journal Of Kidney Diseases, 1999, v. 34 n. 2, p. 315-323en_US
dc.identifier.issn0272-6386en_US
dc.identifier.urihttp://hdl.handle.net/10722/162296-
dc.description.abstractDespite the improvement in survival of patients with systemic lupus erythematosus (SLE) and associated nephritis in the past 20 years, few studies of the long-term outcome of large cohorts of patients with well- defined histological classes of lupus nephropathy are available. We examined the long-term outcome of 183 patients with lupus nephritis (LN) followed up by the Division of Rheumatology at Queen Mary Hospital (Hong Kong) between 1976 and 1997. Their renal biopsies were classified according to World Health Organization (WHO) criteria. There were 27 men and 156 women. Initial renal biopsy showed the following WHO classes of LN: 2 patients (1%), class I; 9 patients (5%), class II; 46 patients (25%), class III; 101 patients (55%), class IV; and 25 patients (14%), class V. The mean duration of follow-up from the renal biopsy was 130.7 ± 5.9 months (range, 13 to 260 months). The overall 5-, 10-, and 15-year survival and renal survival (survival without dialysis) rates were 98.9%, 94.4%, and 94.4% and 92.1%, 81.2%, and 75.2%, respectively. Univariate analysis showed class IV nephritis, hypertension, impaired renal function (glomerular filtration rate < 50 mL/min), nephrotic syndrome at time of renal biopsy, and failure of complete remission in the first year of treatment were unfavorable predictors for renal survival. Multivariate analysis using the Cox regression model also showed persistent hypertension, class IV nephritis, and incomplete renal remission in the first year were independent risk factors for renal failure. Our results showed the renal survival rate of our patients from South China with LN was similar to that of most reported series of white patients. Prospective randomized studies with well-defined treatment protocols are needed to delineate the optimal treatment strategy for LN.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkden_US
dc.relation.ispartofAmerican Journal of Kidney Diseasesen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney - Pathologyen_US
dc.subject.meshKidney Failure, Chronic - Etiologyen_US
dc.subject.meshLupus Nephritis - Complications - Drug Therapy - Ethnology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Factorsen_US
dc.titleLupus nephritis in southern Chinese patients: Clinicopathologic findings and long-term outcomeen_US
dc.typeArticleen_US
dc.identifier.emailChak Sing Lau:cslau@hku.hken_US
dc.identifier.authorityChak Sing Lau=rp01348en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0272-6386(99)70361-6-
dc.identifier.pmid10430980-
dc.identifier.scopuseid_2-s2.0-0032773218en_US
dc.identifier.volume34en_US
dc.identifier.issue2en_US
dc.identifier.spage315en_US
dc.identifier.epage323en_US
dc.identifier.isiWOS:000081955600019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChi Chiu Mok=7409717748en_US
dc.identifier.scopusauthoridWong, RWS=34875928200en_US
dc.identifier.scopusauthoridChak Sing Lau=14035682100en_US

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