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Article: Previously unrecognized obstructive sleep apnea in Chinese subjects with essential hypertension

TitlePreviously unrecognized obstructive sleep apnea in Chinese subjects with essential hypertension
Authors
Issue Date1999
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
Citation
Lung, 1999, v. 177 n. 6, p. 391-400 How to Cite?
AbstractObstructive sleep apnea (OSA) is found to affect 2-4% of the middle-aged population in several Caucasian studies, whereas the prevalence among other ethnic groups have not been clearly documented. It has been reported that OSA and systemic hypertension are highly associated; we therefore conducted a study on Chinese subjects who were receiving treatment for essential hypertension to assess the prevalence of OSA among this group. Ninety-two consecutive patients being followed up at a hypertension clinic were recruited for a questionnaire survey. The entire study group was aged 54.7 ± 11.7 years, with 40 men. One male subject had a diagnosis of obstructive sleep apnea on nasal continuous positive airway pressure (nCPAP) treatment and 46 subjects agreed to an overnight sleep study. Those who underwent sleep study showed selection bias with a higher body mass index and more symptoms associated with OSA. Of the 46 who underwent sleep study, 16 (34.8%) had an obstructive apnea-hypopnea (AHI) score of ≥5 and excessive daytime sleepiness, with a median score of 26.2 (range, 8.3-64.9). Patients in the group with obstructive sleep apnea syndrome (OSAS) thus defined compared with those without OSAS had more men (64.7 vs 17.20%, p = 0.001) and an excess of smokers (31.5 vs 3.3%. p = 0.01) and had significantly more symptoms of excessive daytime sleepiness (p = 0.001), daytime fatigue (p = 0.007), and witnessed apneas (p = 0.008). Seven patients accepted treatment with nCPAP and reported improvement in symptoms, but there was no detectable change in clinic blood pressure measurements after 3 months of nCPAP treatment. This study demonstrated a high prevalence of previously unidentified OSAS among Chinese patients with essential hypertension. Increased awareness of both doctors and patients toward this potentially treatable problem is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/162286
ISSN
2015 Impact Factor: 2.0
2015 SCImago Journal Rankings: 0.785
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, Men_US
dc.contributor.authorChung, KFen_US
dc.contributor.authorChan, KNen_US
dc.contributor.authorLam, SPen_US
dc.contributor.authorLee, Ken_US
dc.date.accessioned2012-09-05T05:18:40Z-
dc.date.available2012-09-05T05:18:40Z-
dc.date.issued1999en_US
dc.identifier.citationLung, 1999, v. 177 n. 6, p. 391-400en_US
dc.identifier.issn0341-2040en_US
dc.identifier.urihttp://hdl.handle.net/10722/162286-
dc.description.abstractObstructive sleep apnea (OSA) is found to affect 2-4% of the middle-aged population in several Caucasian studies, whereas the prevalence among other ethnic groups have not been clearly documented. It has been reported that OSA and systemic hypertension are highly associated; we therefore conducted a study on Chinese subjects who were receiving treatment for essential hypertension to assess the prevalence of OSA among this group. Ninety-two consecutive patients being followed up at a hypertension clinic were recruited for a questionnaire survey. The entire study group was aged 54.7 ± 11.7 years, with 40 men. One male subject had a diagnosis of obstructive sleep apnea on nasal continuous positive airway pressure (nCPAP) treatment and 46 subjects agreed to an overnight sleep study. Those who underwent sleep study showed selection bias with a higher body mass index and more symptoms associated with OSA. Of the 46 who underwent sleep study, 16 (34.8%) had an obstructive apnea-hypopnea (AHI) score of ≥5 and excessive daytime sleepiness, with a median score of 26.2 (range, 8.3-64.9). Patients in the group with obstructive sleep apnea syndrome (OSAS) thus defined compared with those without OSAS had more men (64.7 vs 17.20%, p = 0.001) and an excess of smokers (31.5 vs 3.3%. p = 0.01) and had significantly more symptoms of excessive daytime sleepiness (p = 0.001), daytime fatigue (p = 0.007), and witnessed apneas (p = 0.008). Seven patients accepted treatment with nCPAP and reported improvement in symptoms, but there was no detectable change in clinic blood pressure measurements after 3 months of nCPAP treatment. This study demonstrated a high prevalence of previously unidentified OSAS among Chinese patients with essential hypertension. Increased awareness of both doctors and patients toward this potentially treatable problem is warranted.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/en_US
dc.relation.ispartofLungen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnthropometryen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshDiscriminant Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Diagnosis - Ethnologyen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolysomnography - Statistics & Numerical Dataen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSleep Apnea, Obstructive - Diagnosis - Ethnologyen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.titlePreviously unrecognized obstructive sleep apnea in Chinese subjects with essential hypertensionen_US
dc.typeArticleen_US
dc.identifier.emailIp, M:msmip@hku.hken_US
dc.identifier.emailChung, KF:kfchung@hkucc.hku.hken_US
dc.identifier.authorityIp, M=rp00347en_US
dc.identifier.authorityChung, KF=rp00377en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10541889en_US
dc.identifier.scopuseid_2-s2.0-0032735250en_US
dc.identifier.hkuros51365-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032735250&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume177en_US
dc.identifier.issue6en_US
dc.identifier.spage391en_US
dc.identifier.epage400en_US
dc.identifier.isiWOS:000083446700005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridIp, M=7102423259en_US
dc.identifier.scopusauthoridChung, KF=7404086681en_US
dc.identifier.scopusauthoridChan, KN=15737866400en_US
dc.identifier.scopusauthoridLam, SP=21534605100en_US
dc.identifier.scopusauthoridLee, K=38163127600en_US

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