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Article: Characterization of the Lmo4 gene encoding a LIM-only protein: Genomic organization and comparative chromosomal mapping

TitleCharacterization of the Lmo4 gene encoding a LIM-only protein: Genomic organization and comparative chromosomal mapping
Authors
Issue Date1999
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/
Citation
Mammalian Genome, 1999, v. 10 n. 11, p. 1089-1094 How to Cite?
AbstractLIM-only (LMO) proteins are transcription regulators that function by mediating protein-protein interaction and include the T cell oncogenes encoding LMO1 and LMO2. The oncogenic functions of LMO1 and LMO2 are thought to be mediated by interaction with LDB1 since they form a multimeric protein complex(es). A new member of the Lmo family, Lmo4, has also recently been identified via its interaction with Ldb1. Sequence analysis of the mouse Lmo4 gene shows that it spans about 18 kb and consists of at least six exons, including two alternatively spliced 5' exons. Unlike Lmo1, the two 5' exons of Lmo4 do not encode protein. Comparison of the Lmo4 gene structure with the other LMO family members shows the exon structure of Lmo4 differs in the position of exon junctions encoding the second LIM domain and in a novel exon-intron junction at the penultimate codon of the gene. Lmo4 is thus the least conserved known member of the LIM-only family in both nucleotide sequence and exon structure. Physical mapping of the Lmo4/LMO4 genes has shown mouse Lmo4 is located on Chromosome (Chr)3 and human LMO4 on Chr 1p22.3. This chromosome location is of interest as it occurs in a region that is deleted in a number of human cancers, indicating a possible role of LMO4 in tumorigenesis, like its relatives LMO1 and LMO2.
Persistent Identifierhttp://hdl.handle.net/10722/162273
ISSN
2015 Impact Factor: 2.078
2015 SCImago Journal Rankings: 2.082
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, Een_US
dc.contributor.authorGrutz, Gen_US
dc.contributor.authorGarner, AAen_US
dc.contributor.authorRamsey, Yen_US
dc.contributor.authorCarter, NPen_US
dc.contributor.authorCopeland, Nen_US
dc.contributor.authorGilbert, DJen_US
dc.contributor.authorJenkins, NAen_US
dc.contributor.authorAgulnick, Aen_US
dc.contributor.authorForster, Aen_US
dc.contributor.authorRabbitts, THen_US
dc.date.accessioned2012-09-05T05:18:34Z-
dc.date.available2012-09-05T05:18:34Z-
dc.date.issued1999en_US
dc.identifier.citationMammalian Genome, 1999, v. 10 n. 11, p. 1089-1094en_US
dc.identifier.issn0938-8990en_US
dc.identifier.urihttp://hdl.handle.net/10722/162273-
dc.description.abstractLIM-only (LMO) proteins are transcription regulators that function by mediating protein-protein interaction and include the T cell oncogenes encoding LMO1 and LMO2. The oncogenic functions of LMO1 and LMO2 are thought to be mediated by interaction with LDB1 since they form a multimeric protein complex(es). A new member of the Lmo family, Lmo4, has also recently been identified via its interaction with Ldb1. Sequence analysis of the mouse Lmo4 gene shows that it spans about 18 kb and consists of at least six exons, including two alternatively spliced 5' exons. Unlike Lmo1, the two 5' exons of Lmo4 do not encode protein. Comparison of the Lmo4 gene structure with the other LMO family members shows the exon structure of Lmo4 differs in the position of exon junctions encoding the second LIM domain and in a novel exon-intron junction at the penultimate codon of the gene. Lmo4 is thus the least conserved known member of the LIM-only family in both nucleotide sequence and exon structure. Physical mapping of the Lmo4/LMO4 genes has shown mouse Lmo4 is located on Chromosome (Chr)3 and human LMO4 on Chr 1p22.3. This chromosome location is of interest as it occurs in a region that is deleted in a number of human cancers, indicating a possible role of LMO4 in tumorigenesis, like its relatives LMO1 and LMO2.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/en_US
dc.relation.ispartofMammalian Genomeen_US
dc.subject.meshAdaptor Proteins, Signal Transducingen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 1en_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshExons - Geneticsen_US
dc.subject.meshGenomic Libraryen_US
dc.subject.meshHomeodomain Proteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshIntrons - Geneticsen_US
dc.subject.meshLim Domain Proteinsen_US
dc.subject.meshMetalloproteins - Geneticsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMuridaeen_US
dc.subject.meshNuclear Proteinsen_US
dc.subject.meshOncogene Proteinsen_US
dc.subject.meshProto-Oncogene Proteinsen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.titleCharacterization of the Lmo4 gene encoding a LIM-only protein: Genomic organization and comparative chromosomal mappingen_US
dc.typeArticleen_US
dc.identifier.emailTse, E:ewctse@hku.hken_US
dc.identifier.authorityTse, E=rp00471en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s003359901167en_US
dc.identifier.pmid10556429-
dc.identifier.scopuseid_2-s2.0-0032696589en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032696589&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue11en_US
dc.identifier.spage1089en_US
dc.identifier.epage1094en_US
dc.identifier.isiWOS:000083305600009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, E=7005019454en_US
dc.identifier.scopusauthoridGrutz, G=14524658600en_US
dc.identifier.scopusauthoridGarner, AA=21334249900en_US
dc.identifier.scopusauthoridRamsey, Y=6506145348en_US
dc.identifier.scopusauthoridCarter, NP=7201454539en_US
dc.identifier.scopusauthoridCopeland, N=35374759300en_US
dc.identifier.scopusauthoridGilbert, DJ=7401956091en_US
dc.identifier.scopusauthoridJenkins, NA=35379887700en_US
dc.identifier.scopusauthoridAgulnick, A=6603008802en_US
dc.identifier.scopusauthoridForster, A=7201638425en_US
dc.identifier.scopusauthoridRabbitts, TH=7103136845en_US

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