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Article: Compartmentalization of pro-inflammatory cytokines in tuberculous pleurisy

TitleCompartmentalization of pro-inflammatory cytokines in tuberculous pleurisy
Authors
Issue Date1998
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 1998, v. 92 n. 1, p. 14-17 How to Cite?
AbstractIncreased levels of interleukin-6 (IL-6) and IL-8 are found in various immunologically mediated inflammatory disorders. Concentrations of IL-6, IL-8 and the soluble form of the IL-6 receptor (sIL-6R) were determined in serum and effusion fluid of 25 patients with tuberculous pleurisy utilizing enzyme linked immunosorbent assays (EIA). Serum IL-6 levels were only slightly increased in patients with tuberculous pleurisy in comparison to controls (11.1 ± 2.1 vs 7.3 ± 1.0 pg ml-1). IL-8 could not be detected in the serum of tuberculosis patients, but it was detected in the serum of healthy controls (8.0 ± 1.5 pg ml-1). In comparison to serum, IL-6 and IL-8 were found in high concentrations in pleural effusions (IL-6: 932 ± 70 vs 11.1 ± 2.1 pg ml-1, P < 0.0001; IL-8: 450 ± 85 vs 0 ± 0 pg ml-1). In contrast, sIL-6R concentrations were much higher in serum compared to pleural effusion levels [30,477 ± 1905 vs 9881 ± 1177 pg ml-1, P < 0.0001 (mean ± SEM)]. The authors conclude that elevated levels of IL-6 and IL-8 in pleural effusions are compartmentalized at the site of active disease. The low levels of sIL-6R in the presence of high levels of IL-6 in pleural effusions, and the high levels of sIL-6R in the presence of low levels of IL-6 in serum suggest that the expression or shedding of sIL-6R may be downregulated in the presence of excessive amounts of IL-6.
Persistent Identifierhttp://hdl.handle.net/10722/162241
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHoheisel, Gen_US
dc.contributor.authorIzbicki, Gen_US
dc.contributor.authorRoth, Men_US
dc.contributor.authorChan, CHSen_US
dc.contributor.authorLeung, JCKen_US
dc.contributor.authorReichenberger, Fen_US
dc.contributor.authorSchauer, Jen_US
dc.contributor.authorPerruchoud, APen_US
dc.date.accessioned2012-09-05T05:18:21Z-
dc.date.available2012-09-05T05:18:21Z-
dc.date.issued1998en_US
dc.identifier.citationRespiratory Medicine, 1998, v. 92 n. 1, p. 14-17en_US
dc.identifier.issn0954-6111en_US
dc.identifier.urihttp://hdl.handle.net/10722/162241-
dc.description.abstractIncreased levels of interleukin-6 (IL-6) and IL-8 are found in various immunologically mediated inflammatory disorders. Concentrations of IL-6, IL-8 and the soluble form of the IL-6 receptor (sIL-6R) were determined in serum and effusion fluid of 25 patients with tuberculous pleurisy utilizing enzyme linked immunosorbent assays (EIA). Serum IL-6 levels were only slightly increased in patients with tuberculous pleurisy in comparison to controls (11.1 ± 2.1 vs 7.3 ± 1.0 pg ml-1). IL-8 could not be detected in the serum of tuberculosis patients, but it was detected in the serum of healthy controls (8.0 ± 1.5 pg ml-1). In comparison to serum, IL-6 and IL-8 were found in high concentrations in pleural effusions (IL-6: 932 ± 70 vs 11.1 ± 2.1 pg ml-1, P < 0.0001; IL-8: 450 ± 85 vs 0 ± 0 pg ml-1). In contrast, sIL-6R concentrations were much higher in serum compared to pleural effusion levels [30,477 ± 1905 vs 9881 ± 1177 pg ml-1, P < 0.0001 (mean ± SEM)]. The authors conclude that elevated levels of IL-6 and IL-8 in pleural effusions are compartmentalized at the site of active disease. The low levels of sIL-6R in the presence of high levels of IL-6 in pleural effusions, and the high levels of sIL-6R in the presence of low levels of IL-6 in serum suggest that the expression or shedding of sIL-6R may be downregulated in the presence of excessive amounts of IL-6.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshCytokines - Analysis - Blooden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-6 - Analysisen_US
dc.subject.meshInterleukin-8 - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshPleural Effusion - Blood - Immunologyen_US
dc.subject.meshReceptors, Interleukin-6 - Analysisen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTuberculosis, Pleural - Blood - Immunologyen_US
dc.titleCompartmentalization of pro-inflammatory cytokines in tuberculous pleurisyen_US
dc.typeArticleen_US
dc.identifier.emailLeung, JCK:jckleung@hku.hken_US
dc.identifier.authorityLeung, JCK=rp00448en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0954-6111(98)90025-7en_US
dc.identifier.pmid9519218-
dc.identifier.scopuseid_2-s2.0-0031912239en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031912239&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume92en_US
dc.identifier.issue1en_US
dc.identifier.spage14en_US
dc.identifier.epage17en_US
dc.identifier.isiWOS:000071547400004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHoheisel, G=7004612571en_US
dc.identifier.scopusauthoridIzbicki, G=6701393764en_US
dc.identifier.scopusauthoridRoth, M=7401440443en_US
dc.identifier.scopusauthoridChan, CHS=16169208100en_US
dc.identifier.scopusauthoridLeung, JCK=7202180349en_US
dc.identifier.scopusauthoridReichenberger, F=6701857866en_US
dc.identifier.scopusauthoridSchauer, J=7006383664en_US
dc.identifier.scopusauthoridPerruchoud, AP=7102301958en_US

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