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Article: Age-related osteoporosis in Chinese: An evaluation of the response of intestinal calcium absorption and calcitropic hormones to dietary calcium deprivation

TitleAge-related osteoporosis in Chinese: An evaluation of the response of intestinal calcium absorption and calcitropic hormones to dietary calcium deprivation
Authors
Issue Date1998
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/
Citation
American Journal Of Clinical Nutrition, 1998, v. 68 n. 6, p. 1291-1297 How to Cite?
AbstractBackground: Age-related osteoporosis may be associated with inefficient intestinal calcium absorption and bone remodeling. Objective: We investigated the pathogenesis of age-related osteoporosis in Chinese women with habitual low calcium intakes. Design: We studied the response of intestinal calcium absorption, calcitropic hormones, and biochemical bone markers to graded dietary calcium deprivation. Results: The osteoporotic subjects (n = 25) had higher urinary calcium excretion (P < 0.05) and lower plasma 1,25- dihydroxyvitamin D concentrations (P < 0.02) than did age-matched control women (n = 25). Parathyroid hormone was not significantly different from that in age-matched control women but was significantly higher than in young women (n = 15, P < 0.05). Fractional 45Ca absorption was ≃61% in all 3 groups when the diet was unmodified and increased to 71%, 69%, and 68% in the osteoporotic subjects, age-matched control women, and young women, respectively, when dietary calcium was reduced to 300 mg/d. When the osteoporotic women were calcium deprived, serum 1,25-dihydroxyvitamin D failed to increase but urinary calcium excretion persisted. In contrast, supplementation with 1200 mg Ca resulted in a lowering of parathyroid hormone (P < 0.005 compared with the unmodified diet) and 1,25-dihydroxyvitamin D (P < 0.01) and decreased fractional 45Ca absorption (P < 0.01), suggesting that the increased calcium intake was associated with a potent compensatory ability of the intestine and calcitropic hormones to adapt. Calcium supplementation lowered osteocalcin (P < 0.05) but not alkaline phosphatase, which remained elevated in the osteoporotic subjects at all stages. Conclusions: Elderly osteoporotic women had reduced 1,25-dihydroxyvitamin D production, excessive urinary calcium loss, and high bone turnover. The Chinese women had exceptionally potent intestinal calcium absorption.
Persistent Identifierhttp://hdl.handle.net/10722/162229
ISSN
2015 Impact Factor: 6.703
2015 SCImago Journal Rankings: 3.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorChu, LWen_US
dc.contributor.authorChiu, PKYen_US
dc.date.accessioned2012-09-05T05:18:16Z-
dc.date.available2012-09-05T05:18:16Z-
dc.date.issued1998en_US
dc.identifier.citationAmerican Journal Of Clinical Nutrition, 1998, v. 68 n. 6, p. 1291-1297en_US
dc.identifier.issn0002-9165en_US
dc.identifier.urihttp://hdl.handle.net/10722/162229-
dc.description.abstractBackground: Age-related osteoporosis may be associated with inefficient intestinal calcium absorption and bone remodeling. Objective: We investigated the pathogenesis of age-related osteoporosis in Chinese women with habitual low calcium intakes. Design: We studied the response of intestinal calcium absorption, calcitropic hormones, and biochemical bone markers to graded dietary calcium deprivation. Results: The osteoporotic subjects (n = 25) had higher urinary calcium excretion (P < 0.05) and lower plasma 1,25- dihydroxyvitamin D concentrations (P < 0.02) than did age-matched control women (n = 25). Parathyroid hormone was not significantly different from that in age-matched control women but was significantly higher than in young women (n = 15, P < 0.05). Fractional 45Ca absorption was ≃61% in all 3 groups when the diet was unmodified and increased to 71%, 69%, and 68% in the osteoporotic subjects, age-matched control women, and young women, respectively, when dietary calcium was reduced to 300 mg/d. When the osteoporotic women were calcium deprived, serum 1,25-dihydroxyvitamin D failed to increase but urinary calcium excretion persisted. In contrast, supplementation with 1200 mg Ca resulted in a lowering of parathyroid hormone (P < 0.005 compared with the unmodified diet) and 1,25-dihydroxyvitamin D (P < 0.01) and decreased fractional 45Ca absorption (P < 0.01), suggesting that the increased calcium intake was associated with a potent compensatory ability of the intestine and calcitropic hormones to adapt. Calcium supplementation lowered osteocalcin (P < 0.05) but not alkaline phosphatase, which remained elevated in the osteoporotic subjects at all stages. Conclusions: Elderly osteoporotic women had reduced 1,25-dihydroxyvitamin D production, excessive urinary calcium loss, and high bone turnover. The Chinese women had exceptionally potent intestinal calcium absorption.en_US
dc.languageengen_US
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://www.ajcn.org/en_US
dc.relation.ispartofAmerican Journal of Clinical Nutritionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlkaline Phosphatase - Blooden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCalcitriol - Blooden_US
dc.subject.meshCalcium - Deficiency - Metabolism - Urineen_US
dc.subject.meshCalcium Radioisotopes - Diagnostic Useen_US
dc.subject.meshCalcium, Dietary - Administration & Dosageen_US
dc.subject.meshCollagen - Urineen_US
dc.subject.meshCollagen Type Ien_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestinal Absorptionen_US
dc.subject.meshMatched-Pair Analysisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteocalcin - Blooden_US
dc.subject.meshOsteoporosis, Postmenopausal - Ethnology - Metabolismen_US
dc.subject.meshParathyroid Hormone - Blooden_US
dc.subject.meshPeptides - Urineen_US
dc.titleAge-related osteoporosis in Chinese: An evaluation of the response of intestinal calcium absorption and calcitropic hormones to dietary calcium deprivationen_US
dc.typeArticleen_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.emailChiu, PKY:pkychiu@hkucc.hku.hken_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityChiu, PKY=rp00379en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid9846861-
dc.identifier.scopuseid_2-s2.0-0031772413en_US
dc.identifier.hkuros43585-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031772413&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume68en_US
dc.identifier.issue6en_US
dc.identifier.spage1291en_US
dc.identifier.epage1297en_US
dc.identifier.isiWOS:000077304200024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US
dc.identifier.scopusauthoridChu, LW=7202236665en_US
dc.identifier.scopusauthoridChiu, PKY=7202988127en_US

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