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Article: Partial duplication of the MLL gene in acute myelogenous leukemia without karyotypic aberration

TitlePartial duplication of the MLL gene in acute myelogenous leukemia without karyotypic aberration
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1997, v. 97 n. 1, p. 20-24 How to Cite?
AbstractPartial duplication of the MLL gene is a recently characterized novel genetic mechanism for leukemogenesis. A close association with trisomy 11 ires been observed. A case of acute myelogenous leukemia (AML) M6 without karyotypic abnormality was found to have rearrangement of the MLL gene. Southern analysis with an MLL exon 2 probe revealed partial duplication of the MLL gene, with a duplicated MLL transcript amplified by reverse transcription polymerase chain reaction (RT = PCR). The presence of trisomy 11 was excluded by fluorescence in situ hybridization (FISH). Few cases of AML with MLL gene duplication have been reported, and they showed involvement of the M1, M2, and M4 subtypes. This case is the first reported case with an M6 phenotype, and highlights the importance of investigating for MLL gene mutations in all subtypes of AML, as they may carry prognostic significance.
Persistent Identifierhttp://hdl.handle.net/10722/162210
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:18:09Z-
dc.date.available2012-09-05T05:18:09Z-
dc.date.issued1997en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1997, v. 97 n. 1, p. 20-24en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162210-
dc.description.abstractPartial duplication of the MLL gene is a recently characterized novel genetic mechanism for leukemogenesis. A close association with trisomy 11 ires been observed. A case of acute myelogenous leukemia (AML) M6 without karyotypic abnormality was found to have rearrangement of the MLL gene. Southern analysis with an MLL exon 2 probe revealed partial duplication of the MLL gene, with a duplicated MLL transcript amplified by reverse transcription polymerase chain reaction (RT = PCR). The presence of trisomy 11 was excluded by fluorescence in situ hybridization (FISH). Few cases of AML with MLL gene duplication have been reported, and they showed involvement of the M1, M2, and M4 subtypes. This case is the first reported case with an M6 phenotype, and highlights the importance of investigating for MLL gene mutations in all subtypes of AML, as they may carry prognostic significance.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAgeden_US
dc.subject.meshAlternative Splicingen_US
dc.subject.meshChromosomes, Human, Pair 11 - Geneticsen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Myeloid, Acute - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMultigene Familyen_US
dc.subject.meshMyeloid-Lymphoid Leukemia Proteinen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshProto-Oncogenesen_US
dc.subject.meshTranscription Factorsen_US
dc.titlePartial duplication of the MLL gene in acute myelogenous leukemia without karyotypic aberrationen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(96)00333-0en_US
dc.identifier.pmid9242213-
dc.identifier.scopuseid_2-s2.0-0031214139en_US
dc.identifier.hkuros33220-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031214139&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume97en_US
dc.identifier.issue1en_US
dc.identifier.spage20en_US
dc.identifier.epage24en_US
dc.identifier.isiWOS:A1997XN26200004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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