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Article: Does smoking predispose to peptic ulcer relapse after eradication of Helicobacter pylori?

TitleDoes smoking predispose to peptic ulcer relapse after eradication of Helicobacter pylori?
Authors
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 1997, v. 92 n. 3, p. 442-445 How to Cite?
AbstractObjectives: To investigate whether smoking would increase ulcer recurrence after eradication of Helicobacter pylori (H. pylori) without maintenance acid-suppression therapy. Methods: A total of 287 patients, 256 patients with duodenal ulcers and 31 patients with gastric ulcers, were followed-up for up to 18 months after ulcer healing and successful eradication of H. pylori. There were 83 smokers (defined as smoking > 10 cigarettes/day) and 204 patients who never smoked or stopped smoking after the diagnosis of peptic ulcer disease. None were taking nonsteroidal anti- inflammatory drugs or receiving maintenance acid suppression therapy. Endoscopy was repeated either at the end of the follow-up period or when ulcer symptoms recurred. Results: Of the 83 smokers, 3 (3.6%) had ulcer recurrence, which included two duodenal ulcers and one gastric ulcer. Of the 204 non-smokers, 4 (2.0%) had ulcer relapse, and all being recurrent duodenal ulcers. Four smokers (4.8%) and nine nonsmokers (4.4%) had recurrence of H. pylori infection after 10-18 months. There was no significant difference in ulcer relapse or recurrence of H. pylori infection between smokers and nonsmokers. Conclusions: Cigarette smoking did not increase the recurrence of peptic ulcers after eradication of H. pylori.
Persistent Identifierhttp://hdl.handle.net/10722/162202
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, FKLen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorLee, YTen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorChan, LYen_US
dc.contributor.authorYung, MYen_US
dc.contributor.authorSydney Chung, SCen_US
dc.date.accessioned2012-09-05T05:18:07Z-
dc.date.available2012-09-05T05:18:07Z-
dc.date.issued1997en_US
dc.identifier.citationAmerican Journal Of Gastroenterology, 1997, v. 92 n. 3, p. 442-445en_US
dc.identifier.issn0002-9270en_US
dc.identifier.urihttp://hdl.handle.net/10722/162202-
dc.description.abstractObjectives: To investigate whether smoking would increase ulcer recurrence after eradication of Helicobacter pylori (H. pylori) without maintenance acid-suppression therapy. Methods: A total of 287 patients, 256 patients with duodenal ulcers and 31 patients with gastric ulcers, were followed-up for up to 18 months after ulcer healing and successful eradication of H. pylori. There were 83 smokers (defined as smoking > 10 cigarettes/day) and 204 patients who never smoked or stopped smoking after the diagnosis of peptic ulcer disease. None were taking nonsteroidal anti- inflammatory drugs or receiving maintenance acid suppression therapy. Endoscopy was repeated either at the end of the follow-up period or when ulcer symptoms recurred. Results: Of the 83 smokers, 3 (3.6%) had ulcer recurrence, which included two duodenal ulcers and one gastric ulcer. Of the 204 non-smokers, 4 (2.0%) had ulcer relapse, and all being recurrent duodenal ulcers. Four smokers (4.8%) and nine nonsmokers (4.4%) had recurrence of H. pylori infection after 10-18 months. There was no significant difference in ulcer relapse or recurrence of H. pylori infection between smokers and nonsmokers. Conclusions: Cigarette smoking did not increase the recurrence of peptic ulcers after eradication of H. pylori.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAmoxicillin - Therapeutic Useen_US
dc.subject.meshAntacids - Therapeutic Useen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Therapeutic Useen_US
dc.subject.meshAnti-Ulcer Agents - Therapeutic Useen_US
dc.subject.meshBismuth - Therapeutic Useen_US
dc.subject.meshDuodenal Ulcer - Drug Therapy - Etiology - Microbiologyen_US
dc.subject.meshEndoscopy, Gastrointestinalen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHelicobacter Infections - Drug Therapyen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOmeprazole - Therapeutic Useen_US
dc.subject.meshPenicillins - Therapeutic Useen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.subject.meshStomach Ulcer - Drug Therapy - Etiology - Microbiologyen_US
dc.subject.meshSucralfate - Therapeutic Useen_US
dc.subject.meshWound Healingen_US
dc.titleDoes smoking predispose to peptic ulcer relapse after eradication of Helicobacter pylori?en_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9068465-
dc.identifier.scopuseid_2-s2.0-0031029813en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031029813&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume92en_US
dc.identifier.issue3en_US
dc.identifier.spage442en_US
dc.identifier.epage445en_US
dc.identifier.isiWOS:A1997WL81900013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridLee, YT=35477936800en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridChan, LY=23003415000en_US
dc.identifier.scopusauthoridYung, MY=7101896866en_US
dc.identifier.scopusauthoridSydney Chung, SC=6602724408en_US

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