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Article: Properties of human atrial I(Ca) at physiological temperatures and relevance to action potential

TitleProperties of human atrial I(Ca) at physiological temperatures and relevance to action potential
Authors
Issue Date1997
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1997, v. 272 n. 1 41-1, p. H227-H235 How to Cite?
AbstractThere are no published characterizations of Ca2+ current ((ICa)) at physiological temperatures in human atrium. Depolarization of human atrial myocytes at 36°C elicited I(Ca) that peaked at +10 mV, with a mean maximum current density of 10.8 ± 1.1 pA/pF and no evidence for T-type current. Overlap between activation and inactivation curves and incomplete inactivation during pulses comparable to normal action potential duration (APD) were compatible with the observed role of I(Ca) in maintaining the plateau. I(Ca) was frequency dependent between 0.1 and 2 Hz, and I(Ca) blockade with 0.2 mM Cd2+ reduced rate-dependent changes in APD: under control, APD at 90% repolarization was 230 ± 15 ms at 0.1 Hz and 178 ± 14 ms at 2 Hz (decrease of 52 ± 5 ms); with Cd2+, values were 121 ± 7 ms at 0.1 Hz and 115 ± 6 ms at 2 Hz (decrease of 6 ± 3 ms, P < 0.01). Isoproterenol (1 μM) increased I(Ca) and prolonged APD from 138 ± 13 to 199 ± 15 ms (P < 0.01). These results indicate that, in human atrial cells at 36°C, the properties of L-type I(Ca) contribute importantly to the rate- dependent and autonomic control of APD.
Persistent Identifierhttp://hdl.handle.net/10722/162200
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, GRen_US
dc.contributor.authorNattel, Sen_US
dc.date.accessioned2012-09-05T05:18:02Z-
dc.date.available2012-09-05T05:18:02Z-
dc.date.issued1997en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1997, v. 272 n. 1 41-1, p. H227-H235en_US
dc.identifier.issn0363-6135en_US
dc.identifier.urihttp://hdl.handle.net/10722/162200-
dc.description.abstractThere are no published characterizations of Ca2+ current ((ICa)) at physiological temperatures in human atrium. Depolarization of human atrial myocytes at 36°C elicited I(Ca) that peaked at +10 mV, with a mean maximum current density of 10.8 ± 1.1 pA/pF and no evidence for T-type current. Overlap between activation and inactivation curves and incomplete inactivation during pulses comparable to normal action potential duration (APD) were compatible with the observed role of I(Ca) in maintaining the plateau. I(Ca) was frequency dependent between 0.1 and 2 Hz, and I(Ca) blockade with 0.2 mM Cd2+ reduced rate-dependent changes in APD: under control, APD at 90% repolarization was 230 ± 15 ms at 0.1 Hz and 178 ± 14 ms at 2 Hz (decrease of 52 ± 5 ms); with Cd2+, values were 121 ± 7 ms at 0.1 Hz and 115 ± 6 ms at 2 Hz (decrease of 6 ± 3 ms, P < 0.01). Isoproterenol (1 μM) increased I(Ca) and prolonged APD from 138 ± 13 to 199 ± 15 ms (P < 0.01). These results indicate that, in human atrial cells at 36°C, the properties of L-type I(Ca) contribute importantly to the rate- dependent and autonomic control of APD.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAdrenergic Beta-Agonists - Pharmacologyen_US
dc.subject.meshAtrial Functionen_US
dc.subject.meshCalcium Channels - Physiologyen_US
dc.subject.meshElectric Conductivityen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoproterenol - Pharmacologyen_US
dc.subject.meshMyocardium - Cytology - Metabolismen_US
dc.subject.meshReaction Timeen_US
dc.subject.meshTemperatureen_US
dc.titleProperties of human atrial I(Ca) at physiological temperatures and relevance to action potentialen_US
dc.typeArticleen_US
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_US
dc.identifier.authorityLi, GR=rp00476en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9038942-
dc.identifier.scopuseid_2-s2.0-0031022316en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031022316&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume272en_US
dc.identifier.issue1 41-1en_US
dc.identifier.spageH227en_US
dc.identifier.epageH235en_US
dc.identifier.isiWOS:A1997WG57200027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, GR=7408462932en_US
dc.identifier.scopusauthoridNattel, S=36048738800en_US

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