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Article: Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia

TitleLow frequency of TEL/AML1 in adult acute lymphoblastic leukemia
Authors
Kwong, YLWong, KF
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1997, v. 98 n. 2, p. 137-138 How to Cite?
DOI: http://dx.doi.org/10.1016/S0165-4608(96)00418-9
AbstractTranslocation (12;21)(p13;q22) is a recently characterized aberration in acute lymphoblastic leukemia, and results in the fusion of the TEL and the AML1 genes. It is the most common translocation in pediatric acute lymphoblastic leukemia (ALL), occurring in about one third of the cases. To determine the frequency of TEL/AML1 in adult ALL, we studied 4 cases of T lineage ALL and 26 cases of B lineage ALL. Only one positive case was identified, giving a very low frequency of 3.3%. In this patient, TEL/AML1 was still detectable in complete hematologic remission. The apparent age predilection of t(12;21) warrants further investigations.
Persistent Identifierhttp://hdl.handle.net/10722/162194
ISSN
0165-4608
2012 Impact Factor: 1.929
ISI Accession Number ID
WOS:A1997XZ89500009
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.contributor.authorWong, KFen_US
dc.date.accessioned2012-09-05T05:17:59Z-
dc.date.available2012-09-05T05:17:59Z-
dc.date.issued1997en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1997, v. 98 n. 2, p. 137-138en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162194-
dc.description.abstractTranslocation (12;21)(p13;q22) is a recently characterized aberration in acute lymphoblastic leukemia, and results in the fusion of the TEL and the AML1 genes. It is the most common translocation in pediatric acute lymphoblastic leukemia (ALL), occurring in about one third of the cases. To determine the frequency of TEL/AML1 in adult ALL, we studied 4 cases of T lineage ALL and 26 cases of B lineage ALL. Only one positive case was identified, giving a very low frequency of 3.3%. In this patient, TEL/AML1 was still detectable in complete hematologic remission. The apparent age predilection of t(12;21) warrants further investigations.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshChromosomes, Human, Pair 21en_US
dc.subject.meshCore Binding Factor Alpha 2 Subuniten_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Proteins - Geneticsen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Geneticsen_US
dc.subject.meshProto-Oncogene Proteinsen_US
dc.subject.meshProto-Oncogene Proteins C-Etsen_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleLow frequency of TEL/AML1 in adult acute lymphoblastic leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(96)00418-9en_US
dc.identifier.pmid9332479en_US
dc.identifier.scopuseid_2-s2.0-0030923550en_US
dc.identifier.hkuros33221-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030923550&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue2en_US
dc.identifier.spage137en_US
dc.identifier.epage138en_US
dc.identifier.isiWOS:A1997XZ89500009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.issnl0165-4608-

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