File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Increased rate of apoptosis and decreased expression of bcl-2 protein in peripheral blood lymphocytes from patients with active systemic lupus erythematosus

TitleIncreased rate of apoptosis and decreased expression of bcl-2 protein in peripheral blood lymphocytes from patients with active systemic lupus erythematosus
Authors
Issue Date1997
Citation
Asian Pacific Journal Of Allergy And Immunology, 1997, v. 15 n. 1, p. 3-7 How to Cite?
AbstractDefective regulation of apoptosis may play a role in the development of autoimmune diseases, and the proto-oncogene bcl-2 is known to inhibit cells from undergoing apoptosis. We studied the rate of apoptosis and the expression of bcl-2 in peripheral blood lymphocytes of patients with systemic lupus erythematosus (SLE). A lower proportion of lymphocytes were bcl-2 + in SLE patients with active disease (median 84.9%) than in patients with inactive disease or normal (medians 95.3% and 97.1% respectively, P < 0.05). The rate of apoptosis of freshly isolated PBL was significantly higher in SLE patients than in normal (medians 1.2% vs 0.5%, p < 0.05). After 48-hour culture the apoptotic rate was further increased in SLE patients, particularly those with active disease (SLE overall 34.2%, active 62%, inactive 27.5%, normal 11.5%). These findings support the theory that in SLE patients increased apoptosis may provide a source of extracellular nuclear antigens which stimulate the autoimmune response and form immune complexes with autoantibodies.
Persistent Identifierhttp://hdl.handle.net/10722/162184
ISSN
2015 Impact Factor: 1.269
2015 SCImago Journal Rankings: 0.560
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, EYTen_US
dc.contributor.authorKo, SCWen_US
dc.contributor.authorLau, CSen_US
dc.date.accessioned2012-09-05T05:17:53Z-
dc.date.available2012-09-05T05:17:53Z-
dc.date.issued1997en_US
dc.identifier.citationAsian Pacific Journal Of Allergy And Immunology, 1997, v. 15 n. 1, p. 3-7en_US
dc.identifier.issn0125-877Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/162184-
dc.description.abstractDefective regulation of apoptosis may play a role in the development of autoimmune diseases, and the proto-oncogene bcl-2 is known to inhibit cells from undergoing apoptosis. We studied the rate of apoptosis and the expression of bcl-2 in peripheral blood lymphocytes of patients with systemic lupus erythematosus (SLE). A lower proportion of lymphocytes were bcl-2 + in SLE patients with active disease (median 84.9%) than in patients with inactive disease or normal (medians 95.3% and 97.1% respectively, P < 0.05). The rate of apoptosis of freshly isolated PBL was significantly higher in SLE patients than in normal (medians 1.2% vs 0.5%, p < 0.05). After 48-hour culture the apoptotic rate was further increased in SLE patients, particularly those with active disease (SLE overall 34.2%, active 62%, inactive 27.5%, normal 11.5%). These findings support the theory that in SLE patients increased apoptosis may provide a source of extracellular nuclear antigens which stimulate the autoimmune response and form immune complexes with autoantibodies.en_US
dc.languageengen_US
dc.relation.ispartofAsian Pacific Journal of Allergy and Immunologyen_US
dc.subject.meshApoptosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLupus Erythematosus, Systemic - Blood - Pathologyen_US
dc.subject.meshLymphocytes - Metabolism - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshProto-Oncogene Proteins C-Bcl-2 - Biosynthesisen_US
dc.titleIncreased rate of apoptosis and decreased expression of bcl-2 protein in peripheral blood lymphocytes from patients with active systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.identifier.emailLau, CS:cslau@hku.hken_US
dc.identifier.authorityLau, CS=rp01348en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid9251841-
dc.identifier.scopuseid_2-s2.0-0030790621en_US
dc.identifier.hkuros38162-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030790621&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue1en_US
dc.identifier.spage3en_US
dc.identifier.epage7en_US
dc.identifier.isiWOS:A1997XM18400001-
dc.publisher.placeThailanden_US
dc.identifier.scopusauthoridChan, EYT=7401994013en_US
dc.identifier.scopusauthoridKo, SCW=17735059000en_US
dc.identifier.scopusauthoridLau, CS=14035682100en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats