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Article: Identification of del(6)(q21q25) as a recurring chromosomal abnormality in putative NK cell lymphoma/leukaemia

TitleIdentification of del(6)(q21q25) as a recurring chromosomal abnormality in putative NK cell lymphoma/leukaemia
Authors
Issue Date1997
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1997, v. 98 n. 4, p. 922-926 How to Cite?
AbstractThe putative natural killer (NK) cell lymphomas/leukaemias are a group of recently characterized haematolymphoid malignancies sharing an immunophenotype of CD3/Leu4- CD3ε+ CD56+, and a genotype of germline T- cell receptor genes. They frequently present in extranodal sites and exhibit a highly aggressive clinical course. Information on the cytogenetic or molecular events leading to the tumourigenesis in this group of tumours is very scarce. In this study we analysed the cytogenetic findings of seven patients with CD56-positive putative NK cell lymphoma/leukaemia. Three cases, including one nasal, one extranasal and one leukaemic form, showed a common region of deletion at 6q21-q25, suggesting that this may be a non-random chromosomal aberration.
Persistent Identifierhttp://hdl.handle.net/10722/162180
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorChan, JKCen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:17:52Z-
dc.date.available2012-09-05T05:17:52Z-
dc.date.issued1997en_US
dc.identifier.citationBritish Journal Of Haematology, 1997, v. 98 n. 4, p. 922-926en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162180-
dc.description.abstractThe putative natural killer (NK) cell lymphomas/leukaemias are a group of recently characterized haematolymphoid malignancies sharing an immunophenotype of CD3/Leu4- CD3ε+ CD56+, and a genotype of germline T- cell receptor genes. They frequently present in extranodal sites and exhibit a highly aggressive clinical course. Information on the cytogenetic or molecular events leading to the tumourigenesis in this group of tumours is very scarce. In this study we analysed the cytogenetic findings of seven patients with CD56-positive putative NK cell lymphoma/leukaemia. Three cases, including one nasal, one extranasal and one leukaemic form, showed a common region of deletion at 6q21-q25, suggesting that this may be a non-random chromosomal aberration.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 6 - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshKiller Cells, Natural - Pathologyen_US
dc.subject.meshLeukemia - Geneticsen_US
dc.subject.meshLymphoma, T-Cell - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNose Neoplasms - Geneticsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRecurrenceen_US
dc.titleIdentification of del(6)(q21q25) as a recurring chromosomal abnormality in putative NK cell lymphoma/leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.1997.3223139.x-
dc.identifier.pmid9326190-
dc.identifier.scopuseid_2-s2.0-0030768050en_US
dc.identifier.hkuros33217-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030768050&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue4en_US
dc.identifier.spage922en_US
dc.identifier.epage926en_US
dc.identifier.isiWOS:A1997XZ11100021-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.scopusauthoridChan, JKC=7403287069en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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