File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Acute myeloid leukemia with trisomy 11: A molecular cytogenetic study

TitleAcute myeloid leukemia with trisomy 11: A molecular cytogenetic study
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1997, v. 99 n. 1, p. 19-23 How to Cite?
AbstractTrisomy 11 is uncommon in acute myeloid leukemia (AML) and molecular studies have shown partial tandem duplication of the MLL gene in some cases. In a case of AML with trisomy 11, the MLL gene was found to be randomly duplicated, leading to the formation of a fusion transcript involving splicing of exon 8 to exon 2. Fluorescence in situ hybridization revealed two populations of blasts, with about two-thirds of them showing trisomy 11. These findings suggested that the trisomic and non-trisomic clones had evolved from a clone with a common submicroscopic mutation. As recent studies showed that MLL gene duplication in fact occurs more often as a primary mutation in the absence of trisomy 11, it is possible that in our case the MLL gene duplication might be the common underlying mutation. The clinical course of this case was similar to the poor prognosis reported for trisomy 11.
Persistent Identifierhttp://hdl.handle.net/10722/162174
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.contributor.authorWong, KFen_US
dc.date.accessioned2012-09-05T05:17:49Z-
dc.date.available2012-09-05T05:17:49Z-
dc.date.issued1997en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1997, v. 99 n. 1, p. 19-23en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162174-
dc.description.abstractTrisomy 11 is uncommon in acute myeloid leukemia (AML) and molecular studies have shown partial tandem duplication of the MLL gene in some cases. In a case of AML with trisomy 11, the MLL gene was found to be randomly duplicated, leading to the formation of a fusion transcript involving splicing of exon 8 to exon 2. Fluorescence in situ hybridization revealed two populations of blasts, with about two-thirds of them showing trisomy 11. These findings suggested that the trisomic and non-trisomic clones had evolved from a clone with a common submicroscopic mutation. As recent studies showed that MLL gene duplication in fact occurs more often as a primary mutation in the absence of trisomy 11, it is possible that in our case the MLL gene duplication might be the common underlying mutation. The clinical course of this case was similar to the poor prognosis reported for trisomy 11.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAntigens, Neoplasmen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChromosomes, Human, Pair 11en_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Myeloid, Acute - Genetics - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultigene Familyen_US
dc.subject.meshMyeloid-Lymphoid Leukemia Proteinen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshProto-Oncogenesen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshTranscription Factorsen_US
dc.subject.meshTrisomyen_US
dc.titleAcute myeloid leukemia with trisomy 11: A molecular cytogenetic studyen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(96)00437-2en_US
dc.identifier.pmid9352791-
dc.identifier.scopuseid_2-s2.0-0030731663en_US
dc.identifier.hkuros33223-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030731663&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue1en_US
dc.identifier.spage19en_US
dc.identifier.epage23en_US
dc.identifier.isiWOS:A1997YC66200004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats