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Article: G/A 1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease

TitleG/A 1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease
Authors
Xie, THo, SLLi, LSWMa, OCK
KeywordsCatechol-O-Methyltransferase
Parkinson's Disease
Polymorphism
Issue Date1997
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507419
Citation
Movement Disorders, 1997, v. 12 n. 3, p. 426-427 How to Cite?
DOI: http://dx.doi.org/10.1002/mds.870120325
AbstractHigh and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine 108 polymorphism associated with polymorphic G/A 1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.
Persistent Identifierhttp://hdl.handle.net/10722/162168
ISSN
0885-3185
2023 Impact Factor: 7.4
2023 SCImago Journal Rankings: 2.464
ISI Accession Number ID
WOS:A1997WZ17400023
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorXie, Ten_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorLi, LSWen_US
dc.contributor.authorMa, OCKen_US
dc.date.accessioned2012-09-05T05:17:46Z-
dc.date.available2012-09-05T05:17:46Z-
dc.date.issued1997en_US
dc.identifier.citationMovement Disorders, 1997, v. 12 n. 3, p. 426-427en_US
dc.identifier.issn0885-3185en_US
dc.identifier.urihttp://hdl.handle.net/10722/162168-
dc.description.abstractHigh and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine 108 polymorphism associated with polymorphic G/A 1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507419en_US
dc.relation.ispartofMovement Disordersen_US
dc.subjectCatechol-O-Methyltransferaseen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectPolymorphismen_US
dc.titleG/A 1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailHo, SL:slho@hku.hken_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/mds.870120325en_US
dc.identifier.pmid9159741-
dc.identifier.scopuseid_2-s2.0-0030611325en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030611325&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue3en_US
dc.identifier.spage426en_US
dc.identifier.epage427en_US
dc.identifier.isiWOS:A1997WZ17400023-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXie, T=17535617900en_US
dc.identifier.scopusauthoridHo, SL=25959633500en_US
dc.identifier.scopusauthoridLi, LSW=7501450364en_US
dc.identifier.scopusauthoridMa, OCK=7004452841en_US
dc.identifier.issnl0885-3185-

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