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Article: Autoradiographic mapping of pulmonary NK1 and NK2 tachykinin receptors and changes after repeated antigen challenge in guinea pigs

TitleAutoradiographic mapping of pulmonary NK1 and NK2 tachykinin receptors and changes after repeated antigen challenge in guinea pigs
Authors
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
Citation
Peptides, 1996, v. 17 n. 8, p. 1389-1395 How to Cite?
AbstractAn autoradiographic technique was used to study the distribution of changes in pulmonary NK1 and NK2 receptors in guinea pig lung after repeated antigen challenge. Specific labeling of [3H] CP96345 (NK1 receptors and [3H] SR48968 (NK2 receptors) was localized over the tracheal and bronchial smooth muscle; the density of binding increased towards smaller airways with a higher density for [3H]CP96345 binding. Branchial epithelium and pulmonary blood vessels were also labeled densely with [3H] CP96345. No remarkable difference in the pattern of distribution of pulmonary NK1 and NK2 tachykinin receptors was observed between control, vehicle-challenged, and repeatedly antigen-challenged (weekly for three times) guinea pigs. A significant reduction in specific labeling of [3H] CP96345 (p < 0.01) and [3H]SR48968 (P < 0.05) over pulmonary structures was observed in antigen-challenged compared to control or vehicle-challenged animals. This study provides evidence that NK1 and NK2 tachykinin receptors are both localized to smooth muscle of all sizes in guinea pig airways and provides further evidence for a discrete distribution of NK1 and NK2 tachykinin receptors, consistent with their relative functional activities. In an established model of airway inflammation a decrease in the expression of NK1 and NK2 tachykinin receptors was evident on several different cell types within the lung, and this could influence airway and vascular reactivity.
Persistent Identifierhttp://hdl.handle.net/10722/162165
ISSN
2015 Impact Factor: 2.535
2015 SCImago Journal Rankings: 1.128
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.contributor.authorAstolfi, Men_US
dc.contributor.authorZhang, XLen_US
dc.contributor.authorEvangelista, Sen_US
dc.contributor.authorManzini, Sen_US
dc.contributor.authorBarnes, PJen_US
dc.date.accessioned2012-09-05T05:17:45Z-
dc.date.available2012-09-05T05:17:45Z-
dc.date.issued1996en_US
dc.identifier.citationPeptides, 1996, v. 17 n. 8, p. 1389-1395en_US
dc.identifier.issn0196-9781en_US
dc.identifier.urihttp://hdl.handle.net/10722/162165-
dc.description.abstractAn autoradiographic technique was used to study the distribution of changes in pulmonary NK1 and NK2 receptors in guinea pig lung after repeated antigen challenge. Specific labeling of [3H] CP96345 (NK1 receptors and [3H] SR48968 (NK2 receptors) was localized over the tracheal and bronchial smooth muscle; the density of binding increased towards smaller airways with a higher density for [3H]CP96345 binding. Branchial epithelium and pulmonary blood vessels were also labeled densely with [3H] CP96345. No remarkable difference in the pattern of distribution of pulmonary NK1 and NK2 tachykinin receptors was observed between control, vehicle-challenged, and repeatedly antigen-challenged (weekly for three times) guinea pigs. A significant reduction in specific labeling of [3H] CP96345 (p < 0.01) and [3H]SR48968 (P < 0.05) over pulmonary structures was observed in antigen-challenged compared to control or vehicle-challenged animals. This study provides evidence that NK1 and NK2 tachykinin receptors are both localized to smooth muscle of all sizes in guinea pig airways and provides further evidence for a discrete distribution of NK1 and NK2 tachykinin receptors, consistent with their relative functional activities. In an established model of airway inflammation a decrease in the expression of NK1 and NK2 tachykinin receptors was evident on several different cell types within the lung, and this could influence airway and vascular reactivity.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptidesen_US
dc.relation.ispartofPeptidesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens - Administration & Dosageen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshBenzamides - Metabolismen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshBiphenyl Compounds - Metabolismen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshInflammation - Metabolismen_US
dc.subject.meshLung - Immunology - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshOvalbumin - Administration & Dosage - Immunologyen_US
dc.subject.meshPiperidines - Metabolismen_US
dc.subject.meshReceptors, Neurokinin-1 - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshReceptors, Neurokinin-2 - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshTissue Distributionen_US
dc.titleAutoradiographic mapping of pulmonary NK1 and NK2 tachykinin receptors and changes after repeated antigen challenge in guinea pigsen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0196-9781(96)00238-0en_US
dc.identifier.pmid8971936-
dc.identifier.scopuseid_2-s2.0-0030472818en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030472818&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue8en_US
dc.identifier.spage1389en_US
dc.identifier.epage1395en_US
dc.identifier.isiWOS:A1996VY30200020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridAstolfi, M=7004386058en_US
dc.identifier.scopusauthoridZhang, XL=10243737400en_US
dc.identifier.scopusauthoridEvangelista, S=7004940204en_US
dc.identifier.scopusauthoridManzini, S=7005871596en_US
dc.identifier.scopusauthoridBarnes, PJ=36064679400en_US

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