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- Publisher Website: 10.1016/0165-4608(94)00108-1
- Scopus: eid_2-s2.0-0030200048
- PMID: 8689617
- WOS: WOS:A1996UW98400016
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Article: Essential thrombocythemia with BCR/ABL rearrangement
Title | Essential thrombocythemia with BCR/ABL rearrangement |
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Authors | |
Issue Date | 1996 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene |
Citation | Cancer Genetics And Cytogenetics, 1996, v. 89 n. 1, p. 74-76 How to Cite? |
Abstract | Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-abl positive. The first patient received on allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement. |
Persistent Identifier | http://hdl.handle.net/10722/162162 |
ISSN | 2012 Impact Factor: 1.929 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Kwong, YL | en_US |
dc.contributor.author | Chiu, EKW | en_US |
dc.contributor.author | Liang, RHS | en_US |
dc.contributor.author | Chan, V | en_US |
dc.contributor.author | Chan, TK | en_US |
dc.date.accessioned | 2012-09-05T05:17:44Z | - |
dc.date.available | 2012-09-05T05:17:44Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Cancer Genetics And Cytogenetics, 1996, v. 89 n. 1, p. 74-76 | en_US |
dc.identifier.issn | 0165-4608 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/162162 | - |
dc.description.abstract | Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-abl positive. The first patient received on allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene | en_US |
dc.relation.ispartof | Cancer Genetics and Cytogenetics | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Fusion Proteins, Bcr-Abl - Genetics | en_US |
dc.subject.mesh | Gene Rearrangement | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Thrombocytosis - Genetics | en_US |
dc.title | Essential thrombocythemia with BCR/ABL rearrangement | en_US |
dc.type | Article | en_US |
dc.identifier.email | Kwong, YL:ylkwong@hku.hk | en_US |
dc.identifier.email | Liang, RHS:rliang@hku.hk | en_US |
dc.identifier.email | Chan, V:vnychana@hkucc.hku.hk | en_US |
dc.identifier.authority | Kwong, YL=rp00358 | en_US |
dc.identifier.authority | Liang, RHS=rp00345 | en_US |
dc.identifier.authority | Chan, V=rp00320 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0165-4608(94)00108-1 | en_US |
dc.identifier.pmid | 8689617 | - |
dc.identifier.scopus | eid_2-s2.0-0030200048 | en_US |
dc.identifier.hkuros | 22801 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030200048&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 89 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 74 | en_US |
dc.identifier.epage | 76 | en_US |
dc.identifier.isi | WOS:A1996UW98400016 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kwong, YL=7102818954 | en_US |
dc.identifier.scopusauthorid | Chiu, EKW=24827833600 | en_US |
dc.identifier.scopusauthorid | Liang, RHS=26643224900 | en_US |
dc.identifier.scopusauthorid | Chan, V=7202654865 | en_US |
dc.identifier.scopusauthorid | Chan, TK=7402687762 | en_US |
dc.identifier.issnl | 0165-4608 | - |