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Article: Autoradiographic mapping of beta-adrenoceptors in human skin

TitleAutoradiographic mapping of beta-adrenoceptors in human skin
Authors
Issue Date1996
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00403/index.htm
Citation
Archives Of Dermatological Research, 1996, v. 288 n. 9, p. 549-553 How to Cite?
AbstractA high density of β2-adrenoceptors has been found in human skin. Using autoradiographic mapping we investigated the distribution of β1- and β2-receptors in normal and diseased human skin. Cryostat sections of human skin obtained at biopsy were incubated with [125I]-iodocyanopindolol and nonspecific binding was identified by incubation of adjacent sections with 200 μM (-)-isoproterenol; β2-receptors were visualized using CGP 20712A and β1-receptors using ICI 118,551 as competing agents. The epidermis was densely labelled with an even distribution throughout all layers. Most of the β-receptors were of the β2-subtype, with practically no β1-receptors. β-Receptors were also localized to eccrine sweat glands, dermal blood vessels, and perivascular inflammatory cells, but there was no labelling of sebaceous glands. Topical glucocorticoids caused an increase in the density of epidermal β-receptors. We conclude that keratinocytes and eccrine sweat glands express high densities of β2-receptors, suggesting that they may have a physiological role in the regulation of these cells.
Persistent Identifierhttp://hdl.handle.net/10722/162118
ISSN
2015 Impact Factor: 2.146
2015 SCImago Journal Rankings: 0.900
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSteinkraus, Ven_US
dc.contributor.authorMak, JCWen_US
dc.contributor.authorPichlmeier, Uen_US
dc.contributor.authorMensing, Hen_US
dc.contributor.authorRing, Jen_US
dc.contributor.authorBarnes, PJen_US
dc.date.accessioned2012-09-05T05:17:26Z-
dc.date.available2012-09-05T05:17:26Z-
dc.date.issued1996en_US
dc.identifier.citationArchives Of Dermatological Research, 1996, v. 288 n. 9, p. 549-553en_US
dc.identifier.issn0340-3696en_US
dc.identifier.urihttp://hdl.handle.net/10722/162118-
dc.description.abstractA high density of β2-adrenoceptors has been found in human skin. Using autoradiographic mapping we investigated the distribution of β1- and β2-receptors in normal and diseased human skin. Cryostat sections of human skin obtained at biopsy were incubated with [125I]-iodocyanopindolol and nonspecific binding was identified by incubation of adjacent sections with 200 μM (-)-isoproterenol; β2-receptors were visualized using CGP 20712A and β1-receptors using ICI 118,551 as competing agents. The epidermis was densely labelled with an even distribution throughout all layers. Most of the β-receptors were of the β2-subtype, with practically no β1-receptors. β-Receptors were also localized to eccrine sweat glands, dermal blood vessels, and perivascular inflammatory cells, but there was no labelling of sebaceous glands. Topical glucocorticoids caused an increase in the density of epidermal β-receptors. We conclude that keratinocytes and eccrine sweat glands express high densities of β2-receptors, suggesting that they may have a physiological role in the regulation of these cells.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00403/index.htmen_US
dc.relation.ispartofArchives of Dermatological Researchen_US
dc.subject.meshAutoradiographyen_US
dc.subject.meshEccrine Glands - Chemistryen_US
dc.subject.meshGlucocorticoids - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKeratinocytes - Chemistryen_US
dc.subject.meshReceptors, Adrenergic, Beta - Analysisen_US
dc.subject.meshSkin - Chemistryen_US
dc.titleAutoradiographic mapping of beta-adrenoceptors in human skinen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s004030050101en_US
dc.identifier.pmid8874751-
dc.identifier.scopuseid_2-s2.0-0029741235en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029741235&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume288en_US
dc.identifier.issue9en_US
dc.identifier.spage549en_US
dc.identifier.epage553en_US
dc.identifier.isiWOS:A1996VD39100011-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridSteinkraus, V=7003936215en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridPichlmeier, U=7003293700en_US
dc.identifier.scopusauthoridMensing, H=7005484596en_US
dc.identifier.scopusauthoridRing, J=36045348100en_US
dc.identifier.scopusauthoridBarnes, PJ=36064679400en_US

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