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Article: Hyperdiploid acute myeloid leukemia: Relationship between blast size and karyotype demonstrated by fluorescence in situ hybridization

TitleHyperdiploid acute myeloid leukemia: Relationship between blast size and karyotype demonstrated by fluorescence in situ hybridization
Authors
Issue Date1995
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1995, v. 83 n. 1, p. 1-4 How to Cite?
AbstractHyperdiploidy is a rare finding in acute myeloid leukemia (AML), and the cases described so far showed characteristic large and bizarre blasts. We further demonstrate this morphologic/karyotypic relationship in a case of hyperdiploid AML by fluorescence in situ hybridization. Together with previous observations, we propose that in myeloid leukemias, increase in DNA content is accompanied by a corresponding increase in blast size. If large and bizarre blasts are shown on morphologic analysis, polyploid metaphases on cytogenetic preparations should also be analyzed, as they may be derived from these cells.
Persistent Identifierhttp://hdl.handle.net/10722/162098
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_US
dc.contributor.authorWong, KFen_US
dc.date.accessioned2012-09-05T05:17:19Z-
dc.date.available2012-09-05T05:17:19Z-
dc.date.issued1995en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 1995, v. 83 n. 1, p. 1-4en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162098-
dc.description.abstractHyperdiploidy is a rare finding in acute myeloid leukemia (AML), and the cases described so far showed characteristic large and bizarre blasts. We further demonstrate this morphologic/karyotypic relationship in a case of hyperdiploid AML by fluorescence in situ hybridization. Together with previous observations, we propose that in myeloid leukemias, increase in DNA content is accompanied by a corresponding increase in blast size. If large and bizarre blasts are shown on morphologic analysis, polyploid metaphases on cytogenetic preparations should also be analyzed, as they may be derived from these cells.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAgeden_US
dc.subject.meshDiploidyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Myeloid, Acute - Geneticsen_US
dc.subject.meshMaleen_US
dc.titleHyperdiploid acute myeloid leukemia: Relationship between blast size and karyotype demonstrated by fluorescence in situ hybridizationen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(95)00027-5en_US
dc.identifier.pmid7656196-
dc.identifier.scopuseid_2-s2.0-0029103235en_US
dc.identifier.hkuros12300-
dc.identifier.volume83en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage4en_US
dc.identifier.isiWOS:A1995RT84600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US

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