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Article: Refractory cytopenia with t(1;7), + 8 abnormality and dysplastic eosinophils showing intranuclear Charcot-Leyden crystals: A fluorescence in situ hybridization study

TitleRefractory cytopenia with t(1;7), + 8 abnormality and dysplastic eosinophils showing intranuclear Charcot-Leyden crystals: A fluorescence in situ hybridization study
Authors
Issue Date1995
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1995, v. 90 n. 1, p. 216-218 How to Cite?
AbstractA case of refractory cytopenia and marrow eosinophilia showing t(1;7) translocation and concomitant trisomy 8 is reported. The eosinophils were dysplastic, and showed the unique feature of intranuclear Charcot-Leyden crystal formation, giving rise to a 'lip-like' appearance. We speculate that this unusual cytologic feature resulted from abnormal precipitation of Charcot-Leyden crystal protein in the eosinophils. By fluorescence in situ hybridization using a chromosome 8 specific α-satellite probe, the abnormal eosinophils were shown to have derived from the abnormal clone. We postulate that the dysplastic clone might have retained a differentiation potential and be responsive to normal haemopoietic stimuli.
Persistent Identifierhttp://hdl.handle.net/10722/162086
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, SKen_US
dc.contributor.authorWong, KFen_US
dc.contributor.authorChan, JKCen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:17:10Z-
dc.date.available2012-09-05T05:17:10Z-
dc.date.issued1995en_US
dc.identifier.citationBritish Journal Of Haematology, 1995, v. 90 n. 1, p. 216-218en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162086-
dc.description.abstractA case of refractory cytopenia and marrow eosinophilia showing t(1;7) translocation and concomitant trisomy 8 is reported. The eosinophils were dysplastic, and showed the unique feature of intranuclear Charcot-Leyden crystal formation, giving rise to a 'lip-like' appearance. We speculate that this unusual cytologic feature resulted from abnormal precipitation of Charcot-Leyden crystal protein in the eosinophils. By fluorescence in situ hybridization using a chromosome 8 specific α-satellite probe, the abnormal eosinophils were shown to have derived from the abnormal clone. We postulate that the dysplastic clone might have retained a differentiation potential and be responsive to normal haemopoietic stimuli.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshAnemia, Refractory - Genetics - Pathologyen_US
dc.subject.meshBone Marrow - Pathologyen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosomes, Human, Pair 1en_US
dc.subject.meshChromosomes, Human, Pair 7en_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshEosinophilia - Pathologyen_US
dc.subject.meshEosinophils - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlycoproteins - Analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLysophospholipaseen_US
dc.subject.meshTranslocation, Geneticen_US
dc.subject.meshTrisomyen_US
dc.titleRefractory cytopenia with t(1;7), + 8 abnormality and dysplastic eosinophils showing intranuclear Charcot-Leyden crystals: A fluorescence in situ hybridization studyen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2141.1995.tb03405.x-
dc.identifier.pmid7786789-
dc.identifier.scopuseid_2-s2.0-0029020637en_US
dc.identifier.hkuros5642-
dc.identifier.volume90en_US
dc.identifier.issue1en_US
dc.identifier.spage216en_US
dc.identifier.epage218en_US
dc.identifier.isiWOS:A1995QY07200033-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMa, SK=37020910400en_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.scopusauthoridChan, JKC=7403287069en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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