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Article: Calcium currents in ventricular myocytes of prehypertrophic cardiomyopathic hamsters

TitleCalcium currents in ventricular myocytes of prehypertrophic cardiomyopathic hamsters
Authors
Issue Date1995
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1995, v. 268 n. 3 37-3, p. H999-H1005 How to Cite?
AbstractPossible changes in Ca2+ currents (I(Ca)), which might contribute to Ca2+ overload in young (70- to 100-day-old) cardiomyopathic (CM) hamster hearts, were determined in isolated ventricular myocytes with conventional recording and discontinuous single-electrode voltage-clamp techniques. Action potential duration at 90% repolarization (APD90) was significantly longer in CM myocytes compared with normal cells (APD90 = 120.3 ± 4.5 vs. 98.2 ± 5.9 ms, P < 0.01). Input resistance, membrane time constant, and membrane capacitance were similar in normal and CM myocytes. Current-voltage (I-V) relations for peak I(Ca) were depressed in CM cells compared with normal cells; this difference was statistically significant at the peak of the I-V curve. Activation and inactivation relations for I(Ca) and recovery from inactivation were similar in myocytes from normal and CM hearts. These changes occurred in myocytes from young CM animals before development of heart failure. Results indicate that increased Ca2+ influx through L-type Ca2+ channels does not account for the longer APD in cardiomyopathy and is not involved in the development of Ca2+ overload in cardiomyopathy.
Persistent Identifierhttp://hdl.handle.net/10722/162083
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, GRen_US
dc.contributor.authorFerrier, GRen_US
dc.contributor.authorHowlett, SEen_US
dc.date.accessioned2012-09-05T05:17:08Z-
dc.date.available2012-09-05T05:17:08Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1995, v. 268 n. 3 37-3, p. H999-H1005en_US
dc.identifier.issn0363-6135en_US
dc.identifier.urihttp://hdl.handle.net/10722/162083-
dc.description.abstractPossible changes in Ca2+ currents (I(Ca)), which might contribute to Ca2+ overload in young (70- to 100-day-old) cardiomyopathic (CM) hamster hearts, were determined in isolated ventricular myocytes with conventional recording and discontinuous single-electrode voltage-clamp techniques. Action potential duration at 90% repolarization (APD90) was significantly longer in CM myocytes compared with normal cells (APD90 = 120.3 ± 4.5 vs. 98.2 ± 5.9 ms, P < 0.01). Input resistance, membrane time constant, and membrane capacitance were similar in normal and CM myocytes. Current-voltage (I-V) relations for peak I(Ca) were depressed in CM cells compared with normal cells; this difference was statistically significant at the peak of the I-V curve. Activation and inactivation relations for I(Ca) and recovery from inactivation were similar in myocytes from normal and CM hearts. These changes occurred in myocytes from young CM animals before development of heart failure. Results indicate that increased Ca2+ influx through L-type Ca2+ channels does not account for the longer APD in cardiomyopathy and is not involved in the development of Ca2+ overload in cardiomyopathy.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAction Potentials - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCalcium Channels - Metabolismen_US
dc.subject.meshCardiomyopathy, Hypertrophic - Etiology - Metabolism - Physiopathologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshHeart Ventricles - Metabolism - Physiopathologyen_US
dc.subject.meshIon Transporten_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Physiologyen_US
dc.subject.meshMesocricetusen_US
dc.titleCalcium currents in ventricular myocytes of prehypertrophic cardiomyopathic hamstersen_US
dc.typeArticleen_US
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_US
dc.identifier.authorityLi, GR=rp00476en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7900897-
dc.identifier.scopuseid_2-s2.0-0028964170en_US
dc.identifier.volume268en_US
dc.identifier.issue3 37-3en_US
dc.identifier.spageH999en_US
dc.identifier.epageH1005en_US
dc.identifier.isiWOS:A1995QL35800010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, GR=7408462932en_US
dc.identifier.scopusauthoridFerrier, GR=7005858840en_US
dc.identifier.scopusauthoridHowlett, SE=7006189343en_US

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