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Article: Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage

TitleBiliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage
Authors
Issue Date1995
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/gie
Citation
Gastrointestinal Endoscopy, 1995, v. 42 n. 5, p. 439-444 How to Cite?
AbstractBackground: Immunoglobulin A is the predominant immunoglobulin in the bile. Data on the effects of biliary obstruction on IgA secretion are few. Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by insertion of nasobiliary catheters. Single samples of common duct bile from patients with gallstones (n = 24) were collected as controls. Bile samples collected were measured for total IgA, secretory IgA, and free secretory component levels by sandwich enzyme-linked immunosorbent assays. Results: Bile total IgA, secretory IgA, and free secretory component in the common duct stones group (82.7 ± 11.4 μg/ml, 18.4 ± 1.7 μg/ml, 0.74 ± 0.15 μg/ml) and the malignant obstructive jaundice group (81.6 ± 10.7 μg/ml, 18.2 ± 2.4 μg/ml, 0.57 ± 0.12 μg/ml) were found to be significantly lower than those of the control gallstone patients (104.8 ± 3.4 μg/ml, 33.2 ± 2.9 μg/ml, 1.03 ± 0.12 μg/ml) (P < 0.05). Serum secretory IgA levels in the common duct stones (26.53 ± 1.75 μg/ml) and malignant obstructive jaundice groups (26.03 ± 3.48 μg/ml) were significantly higher than the gallstone group (18.45 ± 4.56 μg/ml). The bile-to-serum concentration ratio of total IgA, secretory IgA, and free secretory component levels rose significantly within 48 hours after relief of obstruction. Conclusions: Biliary obstruction secondary to both calculus or malignancy of the hepatobiliary system causes suppression of bile IgA secretion and elevated serum level of secretory IgA. Bile secretory IgA secretion recovers with endoscopic drainage of the obstructed system.
Persistent Identifierhttp://hdl.handle.net/10722/162067
ISSN
2015 Impact Factor: 6.217
2015 SCImago Journal Rankings: 2.390
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSung, JJYen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorTsui, CPen_HK
dc.contributor.authorChung, SCSen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2012-09-05T05:17:02Z-
dc.date.available2012-09-05T05:17:02Z-
dc.date.issued1995en_HK
dc.identifier.citationGastrointestinal Endoscopy, 1995, v. 42 n. 5, p. 439-444en_HK
dc.identifier.issn0016-5107en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162067-
dc.description.abstractBackground: Immunoglobulin A is the predominant immunoglobulin in the bile. Data on the effects of biliary obstruction on IgA secretion are few. Methods: The serum and bile IgA levels in patients with common duct stones (n = 27) or with malignant obstructive jaundice (n = 20) were collected by insertion of nasobiliary catheters. Single samples of common duct bile from patients with gallstones (n = 24) were collected as controls. Bile samples collected were measured for total IgA, secretory IgA, and free secretory component levels by sandwich enzyme-linked immunosorbent assays. Results: Bile total IgA, secretory IgA, and free secretory component in the common duct stones group (82.7 ± 11.4 μg/ml, 18.4 ± 1.7 μg/ml, 0.74 ± 0.15 μg/ml) and the malignant obstructive jaundice group (81.6 ± 10.7 μg/ml, 18.2 ± 2.4 μg/ml, 0.57 ± 0.12 μg/ml) were found to be significantly lower than those of the control gallstone patients (104.8 ± 3.4 μg/ml, 33.2 ± 2.9 μg/ml, 1.03 ± 0.12 μg/ml) (P < 0.05). Serum secretory IgA levels in the common duct stones (26.53 ± 1.75 μg/ml) and malignant obstructive jaundice groups (26.03 ± 3.48 μg/ml) were significantly higher than the gallstone group (18.45 ± 4.56 μg/ml). The bile-to-serum concentration ratio of total IgA, secretory IgA, and free secretory component levels rose significantly within 48 hours after relief of obstruction. Conclusions: Biliary obstruction secondary to both calculus or malignancy of the hepatobiliary system causes suppression of bile IgA secretion and elevated serum level of secretory IgA. Bile secretory IgA secretion recovers with endoscopic drainage of the obstructed system.en_HK
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/gieen_HK
dc.relation.ispartofGastrointestinal Endoscopyen_HK
dc.subject.meshAgeden_US
dc.subject.meshBile - Immunologyen_US
dc.subject.meshBile Duct Neoplasms - Complicationsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCholestasis, Extrahepatic - Etiology - Immunology - Therapyen_US
dc.subject.meshCommon Bile Duct Neoplasms - Complicationsen_US
dc.subject.meshDrainageen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallstones - Complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A - Analysis - Metabolismen_US
dc.subject.meshImmunoglobulin A, Secretory - Analysis - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPancreatic Neoplasms - Complicationsen_US
dc.subject.meshSecretory Component - Analysis - Metabolismen_US
dc.titleBiliary IgA secretion in obstructive jaundice: The effects of endoscopic drainageen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0016-5107(95)70047-1en_HK
dc.identifier.pmid8566635-
dc.identifier.scopuseid_2-s2.0-0028856305en_HK
dc.identifier.volume42en_HK
dc.identifier.issue5en_HK
dc.identifier.spage439en_HK
dc.identifier.epage444en_HK
dc.identifier.isiWOS:A1995TE96500012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSung, JJY=35405352400en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridTsui, CP=7103323551en_HK
dc.identifier.scopusauthoridChung, SCS=19642462800en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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