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Article: Time-course of neuropeptide changes in peri-ischemic zone and amygdala following focal ischemia in rats

TitleTime-course of neuropeptide changes in peri-ischemic zone and amygdala following focal ischemia in rats
Authors
Issue Date1995
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248
Citation
Journal Of Comparative Neurology, 1995, v. 360 n. 1, p. 101-120 How to Cite?
AbstractPreviously, using a middle cerebral artery occlusion model in Wistar rat, we showed autonomic disturbances similar to those seen clinically and observed striking neurochemical changes in cortical and subcortical sites at 5 days following stroke. The neurochemical changes may account for functional recovery and/or autonomic disturbances after focal ischemia. To understand the possible mechanisms and to facilitate future studies, it is necessary to define the time-courses of these changes. Using immunohistochemical staining with the peroxidase-antiperoxidase reaction, the changes in several neuropeptides over the peri-ischemic region and the ipsilateral central and basolateral nucleus of the amygdala were investigated at different times after middle cerebral artery occlusion. In the experimental group, neuropeptide Y immunoreactivity appeared to increase by 6 hours in the peri- ischemic region. Using image analysis to quantify the staining intensity, the change became statistically significant at 1 day, peaked around 3 days, and subsided at 10 days. There was a delayed increase in neuropeptide Y in the ipsilateral basolateral nucleus of the amygdala with a peak around 3 days. Immunoreactive staining for leucine-enkephalin, dynorphin, and neurotensin demonstrated an increase that was localized to the ipsilateral central nucleus of the amygdala with a peak around 3 days and a return to baseline levels by 10 days. The results support a specific time-course for each of the neuropeptides studied and indicate that a survival time of 3 days after focal ischemia is the critical period for examining the relationship between neuropeptide responses and neuronal or functional recovery.
Persistent Identifierhttp://hdl.handle.net/10722/162066
ISSN
2015 Impact Factor: 3.331
2015 SCImago Journal Rankings: 2.345
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, RTFen_US
dc.contributor.authorDiab, Ten_US
dc.contributor.authorCechetto, DFen_US
dc.date.accessioned2012-09-05T05:17:01Z-
dc.date.available2012-09-05T05:17:01Z-
dc.date.issued1995en_US
dc.identifier.citationJournal Of Comparative Neurology, 1995, v. 360 n. 1, p. 101-120en_US
dc.identifier.issn0021-9967en_US
dc.identifier.urihttp://hdl.handle.net/10722/162066-
dc.description.abstractPreviously, using a middle cerebral artery occlusion model in Wistar rat, we showed autonomic disturbances similar to those seen clinically and observed striking neurochemical changes in cortical and subcortical sites at 5 days following stroke. The neurochemical changes may account for functional recovery and/or autonomic disturbances after focal ischemia. To understand the possible mechanisms and to facilitate future studies, it is necessary to define the time-courses of these changes. Using immunohistochemical staining with the peroxidase-antiperoxidase reaction, the changes in several neuropeptides over the peri-ischemic region and the ipsilateral central and basolateral nucleus of the amygdala were investigated at different times after middle cerebral artery occlusion. In the experimental group, neuropeptide Y immunoreactivity appeared to increase by 6 hours in the peri- ischemic region. Using image analysis to quantify the staining intensity, the change became statistically significant at 1 day, peaked around 3 days, and subsided at 10 days. There was a delayed increase in neuropeptide Y in the ipsilateral basolateral nucleus of the amygdala with a peak around 3 days. Immunoreactive staining for leucine-enkephalin, dynorphin, and neurotensin demonstrated an increase that was localized to the ipsilateral central nucleus of the amygdala with a peak around 3 days and a return to baseline levels by 10 days. The results support a specific time-course for each of the neuropeptides studied and indicate that a survival time of 3 days after focal ischemia is the critical period for examining the relationship between neuropeptide responses and neuronal or functional recovery.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248en_US
dc.relation.ispartofJournal of Comparative Neurologyen_US
dc.subject.meshAmygdala - Blood Supply - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCerebral Cortex - Metabolismen_US
dc.subject.meshDynorphins - Metabolismen_US
dc.subject.meshEnkephalin, Leucine - Metabolismen_US
dc.subject.meshIschemic Attack, Transient - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshNeuropeptide Y - Metabolismen_US
dc.subject.meshNeuropeptides - Metabolismen_US
dc.subject.meshNeurotensin - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTyrosine 3-Monooxygenase - Metabolismen_US
dc.titleTime-course of neuropeptide changes in peri-ischemic zone and amygdala following focal ischemia in ratsen_US
dc.typeArticleen_US
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cne.903600108en_US
dc.identifier.pmid7499557en_US
dc.identifier.scopuseid_2-s2.0-0028840333en_US
dc.identifier.volume360en_US
dc.identifier.issue1en_US
dc.identifier.spage101en_US
dc.identifier.epage120en_US
dc.identifier.isiWOS:A1995RT21200007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, RTF=7202397498en_US
dc.identifier.scopusauthoridDiab, T=6603290337en_US
dc.identifier.scopusauthoridCechetto, DF=7006226109en_US

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