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Article: Changes in regional ventilation during histamine bronchial challenge in stable asthma

TitleChanges in regional ventilation during histamine bronchial challenge in stable asthma
Authors
Issue Date1994
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/RES
Citation
Respiration, 1994, v. 61 n. 2, p. 68-73 How to Cite?
AbstractOur objective was to examine the changes in regional ventilation during histamine-induced bronchoconstriction in stable asthma. We measured regional ventilation by a new method which measures regional distribution of inhaled 127Xe during tidal breathing by a gated method and by simultaneously measuring 99mTc counts from labelled macroaggregates, allowed for changes in lung shape during the breathing cycle. We studied 10 asthmatic patients [forced expiratory volume in 1 s (FEV1 2.04-4.37 litres)] and measured, in addition to the regional ventilation, oxygen saturation (SaO2), minute ventilation (V(E)) and tidal volume (V(t)) before and after inhaling enough histamine to lower FEV1 by >20% and/or SaO2 by >4%. Histamine inhalation reduced FEV1 by 0.44-1.15 liters and SaO2 by 0-4%. It increased V(E) and functional residual capacity (FRC) in 8 of the 10 patients. The FEV1 fall did not correlate with the SaO2 fall, V(E) or FRC changes. Histamine inhalation increased apical ventilation in most patients but the changes in regional ventilation in the left and right lungs were asymmetrical in 17 out of the 30 lung regions studied (upper, middle and lower paired regions in 10 patients). These results demonstrate that histamine bronchial challenge causes uneven regional ventilation. 0Any resultant change in ventilation-perfusion balance may be the underlying mechanism of oxygen desaturation seen in this procedure and in spontaneous attacks of asthma.
Persistent Identifierhttp://hdl.handle.net/10722/162049
ISSN
2015 Impact Factor: 2.651
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWhyte, KFen_US
dc.contributor.authorIp, Men_US
dc.contributor.authorKirby, Ten_US
dc.contributor.authorWathen, CGen_US
dc.contributor.authorFlenley, DCen_US
dc.date.accessioned2012-09-05T05:16:54Z-
dc.date.available2012-09-05T05:16:54Z-
dc.date.issued1994en_US
dc.identifier.citationRespiration, 1994, v. 61 n. 2, p. 68-73en_US
dc.identifier.issn0025-7931en_US
dc.identifier.urihttp://hdl.handle.net/10722/162049-
dc.description.abstractOur objective was to examine the changes in regional ventilation during histamine-induced bronchoconstriction in stable asthma. We measured regional ventilation by a new method which measures regional distribution of inhaled 127Xe during tidal breathing by a gated method and by simultaneously measuring 99mTc counts from labelled macroaggregates, allowed for changes in lung shape during the breathing cycle. We studied 10 asthmatic patients [forced expiratory volume in 1 s (FEV1 2.04-4.37 litres)] and measured, in addition to the regional ventilation, oxygen saturation (SaO2), minute ventilation (V(E)) and tidal volume (V(t)) before and after inhaling enough histamine to lower FEV1 by >20% and/or SaO2 by >4%. Histamine inhalation reduced FEV1 by 0.44-1.15 liters and SaO2 by 0-4%. It increased V(E) and functional residual capacity (FRC) in 8 of the 10 patients. The FEV1 fall did not correlate with the SaO2 fall, V(E) or FRC changes. Histamine inhalation increased apical ventilation in most patients but the changes in regional ventilation in the left and right lungs were asymmetrical in 17 out of the 30 lung regions studied (upper, middle and lower paired regions in 10 patients). These results demonstrate that histamine bronchial challenge causes uneven regional ventilation. 0Any resultant change in ventilation-perfusion balance may be the underlying mechanism of oxygen desaturation seen in this procedure and in spontaneous attacks of asthma.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/RESen_US
dc.relation.ispartofRespirationen_US
dc.subject.meshAdulten_US
dc.subject.meshAsthma - Blood - Physiopathology - Radionuclide Imagingen_US
dc.subject.meshBronchial Provocation Testsen_US
dc.subject.meshBronchoconstriction - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volume - Drug Effectsen_US
dc.subject.meshFunctional Residual Capacity - Drug Effectsen_US
dc.subject.meshHistamine - Diagnostic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Radionuclide Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxygen - Blooden_US
dc.subject.meshRespirationen_US
dc.titleChanges in regional ventilation during histamine bronchial challenge in stable asthmaen_US
dc.typeArticleen_US
dc.identifier.emailIp, M:msmip@hku.hken_US
dc.identifier.authorityIp, M=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000196309-
dc.identifier.pmid8008990-
dc.identifier.scopuseid_2-s2.0-0028280331en_US
dc.identifier.volume61en_US
dc.identifier.issue2en_US
dc.identifier.spage68en_US
dc.identifier.epage73en_US
dc.identifier.isiWOS:A1994NK44500002-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridWhyte, KF=7003632957en_US
dc.identifier.scopusauthoridIp, M=7102423259en_US
dc.identifier.scopusauthoridKirby, T=7005213809en_US
dc.identifier.scopusauthoridWathen, CG=7003645541en_US
dc.identifier.scopusauthoridFlenley, DC=7005713954en_US

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