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Article: Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population

TitleUse of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population
Authors
KeywordsAntimyeloperoxidase antibodies
Antineutrophil cytoplasmic autoantibodies
Antiproteinase 3 antibodies
Chinese
Vasculitis
Issue Date1994
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/AJN
Citation
American Journal Of Nephrology, 1994, v. 14 n. 2, p. 99-105 How to Cite?
AbstractAntineutrophil cytoplasmic autoantibodies (ANCA) have been used as markers of systemic vasculitides, including microscopic polyarteritis (MPA) and Wegener's granulomatosis. The diagnostic potential of ANCA assays together with antibodies against the neutrophil enzymes myeloperoxidase (MPO) and proteinase 3 for detecting a systemic vasculitis was tested in a Chinese patient population. 672 sera were received for ANCA assay, and ANCA detected by indirect immunofluorescence was positive in 73 sera from 42 patients. Of the 42 patients, 3 had cytoplasmic ANCA, while 39 had a perinuclear pattern. There was no patient with Wegener's granulomatosis. Two cytoplasmic ANCA positive patients suffered from ulcerative colitis. Another cytoplasmic ANCA positive patient was a carrier of human immunodeficiency virus. Of the 39 perinuclear ANCA positive patients, 10 had MPA. Eight of them were tested for anti-MPO antibody, and all were positive. Other immune disorders that were perinuclear ANCA positive included: 13 patients with systemic lupus erythematosus, 3 with mixed connective tissue disease, 1 with Goodpasture's syndrome, 2 with inflammatory bowel disease, and 2 patients with IgA nephropathy. Anti-MPO antibody was not specific for MPA, and 7 out of the 13 patients with systemic lupus erythematosus were anti-MPO antibody positive. Our study suggests that ANCA and anti-MPO antibody are not specific for MPA in a Chinese population. They would alert the clinician of the possibility of vasculitis, but a clinicopathological correlation is essential in making the diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/162048
ISSN
2015 Impact Factor: 2.605
2015 SCImago Journal Rankings: 1.308

 

DC FieldValueLanguage
dc.contributor.authorLi, PKTen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLai, FMen_HK
dc.contributor.authorWang, AYMen_HK
dc.contributor.authorLui, SFen_HK
dc.contributor.authorLeung, CBen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2012-09-05T05:16:53Z-
dc.date.available2012-09-05T05:16:53Z-
dc.date.issued1994en_HK
dc.identifier.citationAmerican Journal Of Nephrology, 1994, v. 14 n. 2, p. 99-105en_HK
dc.identifier.issn0250-8095en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162048-
dc.description.abstractAntineutrophil cytoplasmic autoantibodies (ANCA) have been used as markers of systemic vasculitides, including microscopic polyarteritis (MPA) and Wegener's granulomatosis. The diagnostic potential of ANCA assays together with antibodies against the neutrophil enzymes myeloperoxidase (MPO) and proteinase 3 for detecting a systemic vasculitis was tested in a Chinese patient population. 672 sera were received for ANCA assay, and ANCA detected by indirect immunofluorescence was positive in 73 sera from 42 patients. Of the 42 patients, 3 had cytoplasmic ANCA, while 39 had a perinuclear pattern. There was no patient with Wegener's granulomatosis. Two cytoplasmic ANCA positive patients suffered from ulcerative colitis. Another cytoplasmic ANCA positive patient was a carrier of human immunodeficiency virus. Of the 39 perinuclear ANCA positive patients, 10 had MPA. Eight of them were tested for anti-MPO antibody, and all were positive. Other immune disorders that were perinuclear ANCA positive included: 13 patients with systemic lupus erythematosus, 3 with mixed connective tissue disease, 1 with Goodpasture's syndrome, 2 with inflammatory bowel disease, and 2 patients with IgA nephropathy. Anti-MPO antibody was not specific for MPA, and 7 out of the 13 patients with systemic lupus erythematosus were anti-MPO antibody positive. Our study suggests that ANCA and anti-MPO antibody are not specific for MPA in a Chinese population. They would alert the clinician of the possibility of vasculitis, but a clinicopathological correlation is essential in making the diagnosis.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/AJNen_HK
dc.relation.ispartofAmerican Journal of Nephrologyen_HK
dc.subjectAntimyeloperoxidase antibodiesen_HK
dc.subjectAntineutrophil cytoplasmic autoantibodiesen_HK
dc.subjectAntiproteinase 3 antibodiesen_HK
dc.subjectChineseen_HK
dc.subjectVasculitisen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Glomerular Basement Membrane Disease - Blood - Diagnosis - Immunologyen_US
dc.subject.meshAutoantibodies - Blood - Immunologyen_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshChinaen_US
dc.subject.meshColitis, Ulcerative - Blood - Diagnosis - Immunologyen_US
dc.subject.meshCytoplasm - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshGlomerulonephritis, Iga - Blood - Diagnosis - Immunologyen_US
dc.subject.meshHiv Infections - Blood - Diagnosis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammatory Bowel Diseases - Blood - Diagnosis - Immunologyen_US
dc.subject.meshLupus Erythematosus, Systemic - Blood - Diagnosis - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMixed Connective Tissue Disease - Blood - Diagnosis - Immunologyen_US
dc.subject.meshMyeloblastinen_US
dc.subject.meshNeutrophils - Enzymology - Immunologyen_US
dc.subject.meshPeroxidase - Metabolismen_US
dc.subject.meshPolyarteritis Nodosa - Blood - Diagnosis - Immunologyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshSerine Endopeptidases - Metabolismen_US
dc.subject.meshVasculitis - Blood - Diagnosis - Ethnology - Immunologyen_US
dc.subject.meshWegener Granulomatosis - Blood - Diagnosis - Immunologyen_US
dc.titleUse of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient populationen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7915885-
dc.identifier.scopuseid_2-s2.0-0028279591en_HK
dc.identifier.volume14en_HK
dc.identifier.issue2en_HK
dc.identifier.spage99en_HK
dc.identifier.epage105en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLi, PKT=25928016800en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLai, FM=7202559720en_HK
dc.identifier.scopusauthoridWang, A=13606226000en_HK
dc.identifier.scopusauthoridLui, SF=7102379144en_HK
dc.identifier.scopusauthoridLeung, CB=16750769500en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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