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Article: Anti-Neutrophil cytoplasmic antibodies (ANCA) and inflammatory bowel diseases in chinese

TitleAnti-Neutrophil cytoplasmic antibodies (ANCA) and inflammatory bowel diseases in chinese
Authors
KeywordsAntineutrophil cytoplasmic antibodies
Chinese
Inflammatory bowel disease
Issue Date1994
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1994, v. 39 n. 4, p. 886-892 How to Cite?
AbstractInflammatory bowel diseases are uncommon in the Chinese, but the incidence is rising. Their differentiation from infective colitis is often not clear-cut and diagnosing inflammatory bowel diseases can be difficult in Asia. We have studied Chinese patients with ulcerative colitis (N = 19) and Crohn's disease (N = 12) for anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assays (ELISA). Patients with enteric fever (N = 29) and irritable bowel syndrome (N = 24) were recruited as controls. Seventy-three percent of ulcerative colitis patients exhibited either p-ANCA (31%) or c-ANCA (42%) by IIF. Twenty-five percent of Crohn's disease patients were found to be p-ANCA positive. However these ANCA were nonreactive to anti-α granule, antiproteinase 3, antimyeloperoxidase, or antilactoferrin. All positive patients had extensive colitis. Sera collected from patients suffering from enteric fever and irritable bowel syndrome were negative for ANCA by IIF and ELISA. We concluded that the detection of ANCA is helpful in diagnosing inflammatory bowel diseases. Further attempts to characterize these autoantibodies are needed.
Persistent Identifierhttp://hdl.handle.net/10722/162041
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSung, JYen_HK
dc.contributor.authorChan, FKLen_HK
dc.contributor.authorLawton, Jen_HK
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorLiew, CTen_HK
dc.contributor.authorLeung, NWYen_HK
dc.contributor.authorHsu, Ren_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2012-09-05T05:16:50Z-
dc.date.available2012-09-05T05:16:50Z-
dc.date.issued1994en_HK
dc.identifier.citationDigestive Diseases And Sciences, 1994, v. 39 n. 4, p. 886-892en_HK
dc.identifier.issn0163-2116en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162041-
dc.description.abstractInflammatory bowel diseases are uncommon in the Chinese, but the incidence is rising. Their differentiation from infective colitis is often not clear-cut and diagnosing inflammatory bowel diseases can be difficult in Asia. We have studied Chinese patients with ulcerative colitis (N = 19) and Crohn's disease (N = 12) for anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assays (ELISA). Patients with enteric fever (N = 29) and irritable bowel syndrome (N = 24) were recruited as controls. Seventy-three percent of ulcerative colitis patients exhibited either p-ANCA (31%) or c-ANCA (42%) by IIF. Twenty-five percent of Crohn's disease patients were found to be p-ANCA positive. However these ANCA were nonreactive to anti-α granule, antiproteinase 3, antimyeloperoxidase, or antilactoferrin. All positive patients had extensive colitis. Sera collected from patients suffering from enteric fever and irritable bowel syndrome were negative for ANCA by IIF and ELISA. We concluded that the detection of ANCA is helpful in diagnosing inflammatory bowel diseases. Further attempts to characterize these autoantibodies are needed.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_HK
dc.relation.ispartofDigestive Diseases and Sciencesen_HK
dc.subjectAntineutrophil cytoplasmic antibodiesen_HK
dc.subjectChineseen_HK
dc.subjectInflammatory bowel diseaseen_HK
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Antineutrophil Cytoplasmicen_US
dc.subject.meshAutoantibodies - Analysisen_US
dc.subject.meshBiological Markers - Analysisen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInflammatory Bowel Diseases - Ethnology - Immunologyen_US
dc.subject.meshMaleen_US
dc.titleAnti-Neutrophil cytoplasmic antibodies (ANCA) and inflammatory bowel diseases in chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02087438-
dc.identifier.pmid8149855-
dc.identifier.scopuseid_2-s2.0-0028181792en_HK
dc.identifier.volume39en_HK
dc.identifier.issue4en_HK
dc.identifier.spage886en_HK
dc.identifier.epage892en_HK
dc.identifier.isiWOS:A1994NF52200032-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSung, JY=8978634400en_HK
dc.identifier.scopusauthoridChan, FKL=7202586434en_HK
dc.identifier.scopusauthoridLawton, J=7102180792en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.identifier.scopusauthoridLiew, CT=35809476000en_HK
dc.identifier.scopusauthoridLeung, NWY=26643107200en_HK
dc.identifier.scopusauthoridHsu, R=7101741820en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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