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Article: Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassaemia-1

TitleUltrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassaemia-1
Authors
Issue Date1994
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 1994, v. 344 n. 8928, p. 988-989 How to Cite?
AbstractHomozygous α-thalassaemia-1, a common cause of hydrops fetalis, is usually diagnosed invasively. We measured placental thickness by ultrasound at 10-21 weeks' gestation in 231 at-risk pregnancies. 60 were affected (by DNA analysis). The sensitivity and specificity in detecting affected pregnancies at cut-off of mean placental thickness plus 2 SD before 12 weeks' gestation were 0.72 (95% CI 0.52-0.93) and 0.97 (0.9-1.0). After 12 weeks sensitivity increased to 0.95 (0.89-1.0) and by 18 weeks reached 1.0 (0.60-0.99) without change in specificity. Selection of pregnancies at risk by measurement of placental thickness will reduce the number of invasive diagnostic procedures.
Persistent Identifierhttp://hdl.handle.net/10722/162033
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhosh, Aen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorLam, YHen_HK
dc.contributor.authorFung, Een_HK
dc.contributor.authorChan, Ven_HK
dc.date.accessioned2012-09-05T05:16:47Z-
dc.date.available2012-09-05T05:16:47Z-
dc.date.issued1994en_HK
dc.identifier.citationLancet, 1994, v. 344 n. 8928, p. 988-989en_HK
dc.identifier.issn0140-6736en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162033-
dc.description.abstractHomozygous α-thalassaemia-1, a common cause of hydrops fetalis, is usually diagnosed invasively. We measured placental thickness by ultrasound at 10-21 weeks' gestation in 231 at-risk pregnancies. 60 were affected (by DNA analysis). The sensitivity and specificity in detecting affected pregnancies at cut-off of mean placental thickness plus 2 SD before 12 weeks' gestation were 0.72 (95% CI 0.52-0.93) and 0.97 (0.9-1.0). After 12 weeks sensitivity increased to 0.95 (0.89-1.0) and by 18 weeks reached 1.0 (0.60-0.99) without change in specificity. Selection of pregnancies at risk by measurement of placental thickness will reduce the number of invasive diagnostic procedures.en_HK
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_HK
dc.relation.ispartofLanceten_HK
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Ultrasonographyen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshPlacenta - Ultrasonographyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.subject.meshAlpha-Thalassemia - Genetics - Ultrasonographyen_US
dc.titleUltrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassaemia-1en_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailChan, V: vnychana@hkucc.hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityChan, V=rp00320en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(94)91644-6en_HK
dc.identifier.pmid7934433-
dc.identifier.scopuseid_2-s2.0-0028074591en_HK
dc.identifier.hkuros4694-
dc.identifier.volume344en_HK
dc.identifier.issue8928en_HK
dc.identifier.spage988en_HK
dc.identifier.epage989en_HK
dc.identifier.isiWOS:A1994PK97800012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGhosh, A=7403963873en_HK
dc.identifier.scopusauthoridTang, MHY=35362943900en_HK
dc.identifier.scopusauthoridLam, YH=7202563903en_HK
dc.identifier.scopusauthoridFung, E=35880889500en_HK
dc.identifier.scopusauthoridChan, V=7202654865en_HK

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