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Article: The source and possible significance of hyaluronan in the peritoneal cavity

TitleThe source and possible significance of hyaluronan in the peritoneal cavity
Authors
Issue Date1994
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
Citation
Kidney International, 1994, v. 46 n. 2, p. 527-533 How to Cite?
AbstractThe levels of hyaluronan (HA) were determined in dialysate from patients receiving CAPD. The levels found after the four hour dwell were 0.162 ± 0.08 μg/ml (N = 16) in non-infected fluid and 1.69 ± 1.12 (N = 5) during peritonitis, P < 0.0025. Similarly concentrations in overnight (8 to 10 hours) dwell dialysate were 0.384 ± 0.22 μg/ml (N = 13) when uninfected and 3.17 ± 2.28 (N = 8) during peritonitis, P < 0.0002. Following de novo catheter insertion the initial peritoneal washout yielded HA levels of 0.0032 ± 0.0018 μg/ml (N = 7). In vitro human peritoneal cells synthesized HA, 90% of which was secreted into the culture medium (CM). By dissociative gel permeation chromatography on Sephacryl 1000 there were no significant differences in the molecular size of HA extracted from (a) non-infected fluid, (b) infected fluid and (c), mesothelial cell culture medium. These results indicate that the process of CAPD results in an increase in HA levels in the peritoneal cavity. During episodes of peritonitis these functions are further augmented. The likely source of HA in the dialysate is the peritoneal mesothelial cells. This response may be an initial event in wound repair.
Persistent Identifierhttp://hdl.handle.net/10722/162023
ISSN
2015 Impact Factor: 7.683
2015 SCImago Journal Rankings: 3.181
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorColes, GAen_US
dc.contributor.authorWilliams, JDen_US
dc.contributor.authorDavies, Men_US
dc.date.accessioned2012-09-05T05:16:44Z-
dc.date.available2012-09-05T05:16:44Z-
dc.date.issued1994en_US
dc.identifier.citationKidney International, 1994, v. 46 n. 2, p. 527-533en_US
dc.identifier.issn0085-2538en_US
dc.identifier.urihttp://hdl.handle.net/10722/162023-
dc.description.abstractThe levels of hyaluronan (HA) were determined in dialysate from patients receiving CAPD. The levels found after the four hour dwell were 0.162 ± 0.08 μg/ml (N = 16) in non-infected fluid and 1.69 ± 1.12 (N = 5) during peritonitis, P < 0.0025. Similarly concentrations in overnight (8 to 10 hours) dwell dialysate were 0.384 ± 0.22 μg/ml (N = 13) when uninfected and 3.17 ± 2.28 (N = 8) during peritonitis, P < 0.0002. Following de novo catheter insertion the initial peritoneal washout yielded HA levels of 0.0032 ± 0.0018 μg/ml (N = 7). In vitro human peritoneal cells synthesized HA, 90% of which was secreted into the culture medium (CM). By dissociative gel permeation chromatography on Sephacryl 1000 there were no significant differences in the molecular size of HA extracted from (a) non-infected fluid, (b) infected fluid and (c), mesothelial cell culture medium. These results indicate that the process of CAPD results in an increase in HA levels in the peritoneal cavity. During episodes of peritonitis these functions are further augmented. The likely source of HA in the dialysate is the peritoneal mesothelial cells. This response may be an initial event in wound repair.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.htmlen_US
dc.relation.ispartofKidney Internationalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAscitic Fluid - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshChromatography, Gelen_US
dc.subject.meshDialysis Solutions - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHyaluronic Acid - Isolation & Purification - Metabolismen_US
dc.subject.meshKidney Failure, Chronic - Therapyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeritoneal Cavity - Cytologyen_US
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatoryen_US
dc.subject.meshPeritonitis - Physiopathologyen_US
dc.titleThe source and possible significance of hyaluronan in the peritoneal cavityen_US
dc.typeArticleen_US
dc.identifier.emailYung, S:ssyyung@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ki.1994.304-
dc.identifier.pmid7967367-
dc.identifier.scopuseid_2-s2.0-0027978894en_US
dc.identifier.volume46en_US
dc.identifier.issue2en_US
dc.identifier.spage527en_US
dc.identifier.epage533en_US
dc.identifier.isiWOS:A1994NX94100031-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYung, S=22636568800en_US
dc.identifier.scopusauthoridColes, GA=7102488081en_US
dc.identifier.scopusauthoridWilliams, JD=35600499200en_US
dc.identifier.scopusauthoridDavies, M=7404207291en_US

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