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Article: Ca 2+ release in cultured rat epididymal cells during hypoosmotic swelling

TitleCa 2+ release in cultured rat epididymal cells during hypoosmotic swelling
Authors
KeywordsCa 2+ Store
Hypoosmotic Swelling
Osmoregulation
Rat Epididymis
Issue Date1993
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htm
Citation
Pflugers Archiv European Journal Of Physiology, 1993, v. 425 n. 1-2, p. 77-81 How to Cite?
AbstractMicrofluorimetric studies were carried out to investigate the effects of hypoosmotic swelling on intracellular Ca 2+ concentration ([Ca 2+](i)) in single rat epididymal cells. In Ca 2+-free solution containing 50 μmol/l ethylenebis(oxonitrilo)tetraacetate (EGTA) hypoosmotic swelling (-160 mosmol/l) induced a transient rise in [Ca 2+](i)< which was either monophasic, biphasic or oscillatory. The [Ca 2+](i) responses to repeated hypoosmotic stimulations followed a decremental pattern. However, if 2.5 mmol/l Ca 2+ was admitted during the recovery period between successive stimulations, the second and the third [Ca 2+](i) responses were slightly greater than the first. Increasing the change in osmolarity from -14 ± 1.0 to -154 ± 1.5 mosmol/l increased the rise in [Ca 2+](i) but reduced the [Ca 2+](i) response to subsequent ionomycin stimulation (4 μmol/l). The swelling- and the ionomycin-induced rises in [Ca 2+](i) followed a reciprocal pattern. It was suggested that intracellular Ca 2+ release in response to cell swelling in the epididymal epithelium might play a role in cell volume regulation and the control of epididymal fluid osmolarity.
Persistent Identifierhttp://hdl.handle.net/10722/162015
ISSN
2015 Impact Factor: 3.654
2015 SCImago Journal Rankings: 1.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYHen_US
dc.contributor.authorWong, PYDen_US
dc.date.accessioned2012-09-05T05:16:41Z-
dc.date.available2012-09-05T05:16:41Z-
dc.date.issued1993en_US
dc.identifier.citationPflugers Archiv European Journal Of Physiology, 1993, v. 425 n. 1-2, p. 77-81en_US
dc.identifier.issn0031-6768en_US
dc.identifier.urihttp://hdl.handle.net/10722/162015-
dc.description.abstractMicrofluorimetric studies were carried out to investigate the effects of hypoosmotic swelling on intracellular Ca 2+ concentration ([Ca 2+](i)) in single rat epididymal cells. In Ca 2+-free solution containing 50 μmol/l ethylenebis(oxonitrilo)tetraacetate (EGTA) hypoosmotic swelling (-160 mosmol/l) induced a transient rise in [Ca 2+](i)< which was either monophasic, biphasic or oscillatory. The [Ca 2+](i) responses to repeated hypoosmotic stimulations followed a decremental pattern. However, if 2.5 mmol/l Ca 2+ was admitted during the recovery period between successive stimulations, the second and the third [Ca 2+](i) responses were slightly greater than the first. Increasing the change in osmolarity from -14 ± 1.0 to -154 ± 1.5 mosmol/l increased the rise in [Ca 2+](i) but reduced the [Ca 2+](i) response to subsequent ionomycin stimulation (4 μmol/l). The swelling- and the ionomycin-induced rises in [Ca 2+](i) followed a reciprocal pattern. It was suggested that intracellular Ca 2+ release in response to cell swelling in the epididymal epithelium might play a role in cell volume regulation and the control of epididymal fluid osmolarity.en_US
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htmen_US
dc.relation.ispartofPflugers Archiv European Journal of Physiologyen_US
dc.subjectCa 2+ Storeen_US
dc.subjectHypoosmotic Swellingen_US
dc.subjectOsmoregulationen_US
dc.subjectRat Epididymisen_US
dc.titleCa 2+ release in cultured rat epididymal cells during hypoosmotic swellingen_US
dc.typeArticleen_US
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_US
dc.identifier.authorityLeung, AYH=rp00265en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00374506en_US
dc.identifier.pmid8272386-
dc.identifier.scopuseid_2-s2.0-0027673754en_US
dc.identifier.volume425en_US
dc.identifier.issue1-2en_US
dc.identifier.spage77en_US
dc.identifier.epage81en_US
dc.identifier.isiWOS:A1993MC86700011-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridLeung, AYH=7403012668en_US
dc.identifier.scopusauthoridWong, PYD=7403980262en_US

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