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Article: Multivariate analysis of factors affecting pulmonary function in bronchiectasis

TitleMultivariate analysis of factors affecting pulmonary function in bronchiectasis
Authors
Issue Date1993
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/RES
Citation
Respiration, 1993, v. 60 n. 1, p. 45-50 How to Cite?
AbstractImpaired pulmonary function is of prognostic importance in bronchiectasis. To assess the factors affecting pulmonary function in bronchiectasis, we studied the clinical features, atopic status, bronchial responsiveness, systemic inflammatory indices, and sputum characteristics including volume, purulence, leucocyte count, neutrophil chemotactic activity, elastolytic activity (EA) and bacteriology in 82 Chinese patients. The majority of patients had impaired spirometry with airflow obstruction but normal carbon monoxide diffusing capacity. Multivariate analysis showed that factors significantly associated with worse lung function were: bronchial hyperresponsiveness, concomitant asthma, higher serum globulin, higher peripheral leucocyte count, lower serum albumin, greater sputum volume, diffuse disease and older age. When subjects with clinical asthma were excluded, similar factors were identified, and in addition, longer duration of disease, presence of eosinophils in sputum and higher sputum EA were significantly related to worse spirometry. Most of the identified factors reflect a state of inflammation. Thus the findings suggest that persistent inflammation plays an important role in the deterioration of lung function in bronchiectasis.
Persistent Identifierhttp://hdl.handle.net/10722/162002
ISSN
2015 Impact Factor: 2.651
2015 SCImago Journal Rankings: 1.060
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, Men_US
dc.contributor.authorLauder, IJen_US
dc.contributor.authorWong, WYen_US
dc.contributor.authorLam, WYen_US
dc.contributor.authorSo, SYen_US
dc.date.accessioned2012-09-05T05:16:34Z-
dc.date.available2012-09-05T05:16:34Z-
dc.date.issued1993en_US
dc.identifier.citationRespiration, 1993, v. 60 n. 1, p. 45-50en_US
dc.identifier.issn0025-7931en_US
dc.identifier.urihttp://hdl.handle.net/10722/162002-
dc.description.abstractImpaired pulmonary function is of prognostic importance in bronchiectasis. To assess the factors affecting pulmonary function in bronchiectasis, we studied the clinical features, atopic status, bronchial responsiveness, systemic inflammatory indices, and sputum characteristics including volume, purulence, leucocyte count, neutrophil chemotactic activity, elastolytic activity (EA) and bacteriology in 82 Chinese patients. The majority of patients had impaired spirometry with airflow obstruction but normal carbon monoxide diffusing capacity. Multivariate analysis showed that factors significantly associated with worse lung function were: bronchial hyperresponsiveness, concomitant asthma, higher serum globulin, higher peripheral leucocyte count, lower serum albumin, greater sputum volume, diffuse disease and older age. When subjects with clinical asthma were excluded, similar factors were identified, and in addition, longer duration of disease, presence of eosinophils in sputum and higher sputum EA were significantly related to worse spirometry. Most of the identified factors reflect a state of inflammation. Thus the findings suggest that persistent inflammation plays an important role in the deterioration of lung function in bronchiectasis.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/RESen_US
dc.relation.ispartofRespirationen_US
dc.subject.meshBronchial Provocation Testsen_US
dc.subject.meshBronchiectasis - Diagnosis - Epidemiology - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLung - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshRespiratory Function Testsen_US
dc.subject.meshSputum - Chemistryen_US
dc.titleMultivariate analysis of factors affecting pulmonary function in bronchiectasisen_US
dc.typeArticleen_US
dc.identifier.emailIp, M:msmip@hku.hken_US
dc.identifier.authorityIp, M=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000196172-
dc.identifier.pmid8469819-
dc.identifier.scopuseid_2-s2.0-0027465527en_US
dc.identifier.volume60en_US
dc.identifier.issue1en_US
dc.identifier.spage45en_US
dc.identifier.epage50en_US
dc.identifier.isiWOS:A1993KY19200008-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridIp, M=7102423259en_US
dc.identifier.scopusauthoridLauder, IJ=35564928000en_US
dc.identifier.scopusauthoridWong, WY=36847950400en_US
dc.identifier.scopusauthoridLam, WY=55127148700en_US
dc.identifier.scopusauthoridSo, SY=7102397816en_US

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