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Article: Altered cellular signalling and decreased platelet sensitivity to adenosine in insulin-dependent diabetic patients with proliferative retinopathy

TitleAltered cellular signalling and decreased platelet sensitivity to adenosine in insulin-dependent diabetic patients with proliferative retinopathy
Authors
Issue Date1993
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsig
Citation
Cellular Signalling, 1993, v. 5 n. 2, p. 145-153 How to Cite?
AbstractPlatelets from patients with insulin-dependent diabetes with proliferative retinopathy showed the same reactivity to ADP as those from control subjects. Responsiveness of platelets to the aggregation inhibitor adenosine and to the analogue N-ethylcarboxamidoadenosine was decreased in diabetes. In contrast, responsiveness to the anti-aggregatory effects of prostaglandin I 2 was not significantly altered in diabetes. Platelets from diabetic patients exhibited decreased formation of cyclic AMP in response to N-ethylcarboxamidoadenosine compared with those from control subjects. In contrast, when adenylyl cyclase was stimulated by prostaglandin I 2 or by forskolin, no differences in cyclic AMP formation were observed between control and diabetic platelets. Diabetes was associated with an apparent loss of high-affinity binding of [ 3H]N-ethylcarboxamidoadenosine to platelet membranes. Possible mechanisms that could contribute to this diabetes-induced change in signalling through the platelet A 2 adenosine receptor are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/161995
ISSN
2015 Impact Factor: 4.191
2015 SCImago Journal Rankings: 2.289
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGasser, JAen_US
dc.contributor.authorCooper, MBen_US
dc.contributor.authorTan, KCBen_US
dc.contributor.authorSaggerson, EDen_US
dc.contributor.authorBetteridge, DJen_US
dc.date.accessioned2012-09-05T05:16:31Z-
dc.date.available2012-09-05T05:16:31Z-
dc.date.issued1993en_US
dc.identifier.citationCellular Signalling, 1993, v. 5 n. 2, p. 145-153en_US
dc.identifier.issn0898-6568en_US
dc.identifier.urihttp://hdl.handle.net/10722/161995-
dc.description.abstractPlatelets from patients with insulin-dependent diabetes with proliferative retinopathy showed the same reactivity to ADP as those from control subjects. Responsiveness of platelets to the aggregation inhibitor adenosine and to the analogue N-ethylcarboxamidoadenosine was decreased in diabetes. In contrast, responsiveness to the anti-aggregatory effects of prostaglandin I 2 was not significantly altered in diabetes. Platelets from diabetic patients exhibited decreased formation of cyclic AMP in response to N-ethylcarboxamidoadenosine compared with those from control subjects. In contrast, when adenylyl cyclase was stimulated by prostaglandin I 2 or by forskolin, no differences in cyclic AMP formation were observed between control and diabetic platelets. Diabetes was associated with an apparent loss of high-affinity binding of [ 3H]N-ethylcarboxamidoadenosine to platelet membranes. Possible mechanisms that could contribute to this diabetes-induced change in signalling through the platelet A 2 adenosine receptor are discussed.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsigen_US
dc.relation.ispartofCellular Signallingen_US
dc.subject.meshAdenosine - Analogs & Derivatives - Metabolism - Pharmacologyen_US
dc.subject.meshAdenosine Diphosphate - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshAdenosine-5'-(N-Ethylcarboxamide)en_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshBlood Platelets - Drug Effectsen_US
dc.subject.meshCell Membrane - Metabolismen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Complications - Metabolismen_US
dc.subject.meshDiabetic Retinopathy - Blood - Complications - Metabolismen_US
dc.subject.meshEpoprostenol - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshForskolin - Pharmacologyen_US
dc.subject.meshGtp-Binding Proteins - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPlatelet Aggregation - Drug Effectsen_US
dc.subject.meshReceptors, Purinergic - Metabolismen_US
dc.subject.meshSignal Transduction - Drug Effectsen_US
dc.titleAltered cellular signalling and decreased platelet sensitivity to adenosine in insulin-dependent diabetic patients with proliferative retinopathyen_US
dc.typeArticleen_US
dc.identifier.emailTan, KCB:kcbtan@hku.hken_US
dc.identifier.authorityTan, KCB=rp00402en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0898-6568(93)90066-Uen_US
dc.identifier.pmid8499224-
dc.identifier.scopuseid_2-s2.0-0027418418en_US
dc.identifier.volume5en_US
dc.identifier.issue2en_US
dc.identifier.spage145en_US
dc.identifier.epage153en_US
dc.identifier.isiWOS:A1993KV15600005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGasser, JA=35879184600en_US
dc.identifier.scopusauthoridCooper, MB=7404410514en_US
dc.identifier.scopusauthoridTan, KCB=8082703100en_US
dc.identifier.scopusauthoridSaggerson, ED=7006639728en_US
dc.identifier.scopusauthoridBetteridge, DJ=34973752700en_US

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