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Article: Disseminated mediastinal carcinoma with chromosomal translocation (15;19): A distinctive clinicopathologic syndrome

TitleDisseminated mediastinal carcinoma with chromosomal translocation (15;19): A distinctive clinicopathologic syndrome
Authors
Keywordschildhood
cytogenetics
thymic neoplasm
translocation
Issue Date1993
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1993, v. 72 n. 7, p. 2273-2276 How to Cite?
AbstractBackground. A case of disseminated mediastinal carcinoma probably of thymic origin is reported in a 5-year-old boy with an anterior mediastinal mass associated with superior vena cava obstruction, tracheal deviation, right malignant pleural effusion, and evidence of bone metastasis. The diagnosis was based on findings of radiologic localization, light and electron microscopic study, and immunohistochemistry. The patient received combination chemotherapy but died of progressive disease. Methods. Cytogenic study on the pleural fluid was attempted, and a literature search for similar chromosomal aberration was performed. Results. Cytogenetic study of tumor cells from the pleural fluid revealed a clonal chromosomal abnormality of t(15;19)(q12;p13.1). Two patients with similar disease were reported in the English literature; their clinical courses, immunohistochemical findings, and t(15;19) were almost identical to those of the patient reported in this study. Conclusion. The authors suggest that this translocation may be specific to thymic carcinoma and may indicate a particularly aggressive form of the disease. Carcinomas are rare in children, so the chromosomal translocation may serve as a helpful marker for the diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/161977
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, ACWen_US
dc.contributor.authorKwong, YLen_US
dc.contributor.authorKin Hang Fuen_US
dc.contributor.authorChan, GCFen_US
dc.contributor.authorMa, Len_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2012-09-05T05:16:25Z-
dc.date.available2012-09-05T05:16:25Z-
dc.date.issued1993en_US
dc.identifier.citationCancer, 1993, v. 72 n. 7, p. 2273-2276en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/161977-
dc.description.abstractBackground. A case of disseminated mediastinal carcinoma probably of thymic origin is reported in a 5-year-old boy with an anterior mediastinal mass associated with superior vena cava obstruction, tracheal deviation, right malignant pleural effusion, and evidence of bone metastasis. The diagnosis was based on findings of radiologic localization, light and electron microscopic study, and immunohistochemistry. The patient received combination chemotherapy but died of progressive disease. Methods. Cytogenic study on the pleural fluid was attempted, and a literature search for similar chromosomal aberration was performed. Results. Cytogenetic study of tumor cells from the pleural fluid revealed a clonal chromosomal abnormality of t(15;19)(q12;p13.1). Two patients with similar disease were reported in the English literature; their clinical courses, immunohistochemical findings, and t(15;19) were almost identical to those of the patient reported in this study. Conclusion. The authors suggest that this translocation may be specific to thymic carcinoma and may indicate a particularly aggressive form of the disease. Carcinomas are rare in children, so the chromosomal translocation may serve as a helpful marker for the diagnosis.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectchildhood-
dc.subjectcytogenetics-
dc.subjectthymic neoplasm-
dc.subjecttranslocation-
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma - Genetics - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChromosomes, Human, Pair 15en_US
dc.subject.meshChromosomes, Human, Pair 19en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMediastinal Neoplasms - Genetics - Pathologyen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleDisseminated mediastinal carcinoma with chromosomal translocation (15;19): A distinctive clinicopathologic syndromeen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8374886-
dc.identifier.scopuseid_2-s2.0-0027275415en_US
dc.identifier.hkuros30260-
dc.identifier.volume72en_US
dc.identifier.issue7en_US
dc.identifier.spage2273en_US
dc.identifier.epage2276en_US
dc.identifier.isiWOS:A1993LY17500034-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, ACW=7405631431en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridKin Hang Fu=7409594343en_US
dc.identifier.scopusauthoridChan, GCF=16160154400en_US
dc.identifier.scopusauthoridMa, L=7403574642en_US
dc.identifier.scopusauthoridLau, YL=7201403380en_US

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